Cited by 428interferon and immune responsesImmune Response and InflammationCytokine Signaling Pathways and Interactions

The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion

Levy, D·2001·Cytokine & Growth Factor Reviews

Abstract

Response to IFN involves a rapid and direct signal transduction mechanism that quickly reports that presence of extracellular cytokine to the cell nucleus, preserving the specificity inherent in cytokine-receptor interactions to transcriptionally induce expression of a set of genes encoding important antiviral proteins. Establishment of the resulting antiviral state provides a crucial initial line of defense against viral infection. Studies of IFN-deficient cells and animals derived by gene targeting have demonstrated the essential nature of IFN-mediated innate immunity. The long co-evolutionary history of viruses with their hosts has seen the development of a variety of evasive adaptations that allow viruses to circumvent or inactivate host antiviral mechanisms. Further understanding of both host and viral components of this battle may provide important new strategies for vaccine development and creation of novel antiviral compounds.

Integrity signals

Registry

Crossref · 10.1016/s1359-6101(00)00027-7

Cites

168 of 168 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Levy, D.
Affiliations
NYU Langone Health (US)
Corresponding author
Levy, D
ORCID
Levy, D
Venue
Cytokine & Growth Factor Reviews
Publisher
Elsevier BV
Published
2001-06
Volume
12
Issue
2-3
Pages
143-156
ISSN
1359-6101 (ISSN-L)
OpenAlex
W2043064608
Cited by
428
References
168
Citations by year
2026: 5 · 2025: 10 · 2024: 9 · 2023: 15 · 2022: 16 · 2021: 9 · 2020: 14 · 2019: 10 · 2018: 7 · 2017: 14 · 2016: 16 · 2015: 13 · 2014: 18 · 2013: 17 · 2012: 17
FWCI
10.06
Type
journal article
Language
en
Open access
closed
Locations
  • Cytokine & Growth Factor Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ai046594-05)
  • National Institute of Allergy and Infectious Diseases (AI48204, R01AI046503, AI 28900, AI46594, P01AI048204, AI46503, R01AI028900)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords
interferon, antiviral state, viral evasion, innate immunity, interferon signaling, cytokine-cytokine receptor interaction, antiviral gene expression, host-virus coevolution, antiviral agents
MeSH terms
Animals, Antiviral Agents, DNA-Binding Proteins, Gene Expression Regulation, Humans, Interferons, Protein-Tyrosine Kinases, RNA, Double-Stranded, Viruses, Signal Transduction, Trans-Activators, Receptors, Interferon, eIF-2 Kinase, STAT1 Transcription Factor, Mice, Janus Kinase 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review