The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion
Abstract
Response to IFN involves a rapid and direct signal transduction mechanism that quickly reports that presence of extracellular cytokine to the cell nucleus, preserving the specificity inherent in cytokine-receptor interactions to transcriptionally induce expression of a set of genes encoding important antiviral proteins. Establishment of the resulting antiviral state provides a crucial initial line of defense against viral infection. Studies of IFN-deficient cells and animals derived by gene targeting have demonstrated the essential nature of IFN-mediated innate immunity. The long co-evolutionary history of viruses with their hosts has seen the development of a variety of evasive adaptations that allow viruses to circumvent or inactivate host antiviral mechanisms. Further understanding of both host and viral components of this battle may provide important new strategies for vaccine development and creation of novel antiviral compounds.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
RSV binds RIG-I to inhibit its activity.
“For instance, influenza virus (91) and RSV (161) bind RIG-I and rhinovirus binds MDA5 to inhibit their activity (304)”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [161]
RSV targets the cytoplasmic RIG-I sensor through the NS2 protein.
“RSV targets the cytoplasmic RIG-I sensor through the NS2 protein (161).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [161]
Cites
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · see citing works
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932 · see citing works
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890 · see citing works
Functional Role of Type I and Type II Interferons in Antiviral Defense
Müller, U., Steinhoff, U., Reis, L. F. L., Hemmi, S., Pavlovic, J., Zinkernagel, R. M., & Aguet, M. (1994) · Science · doi:10.1126/science.8009221 · Cited by 2,453 · see citing works
Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex
de Vos, A. M., Ultsch, M. H., & Kossiakoff, A. A. (1992) · Science · doi:10.1126/science.1549776 · Cited by 2,259 · see citing works
Der, S. D., Zhou, A., Williams, B. R. G., & Silverman, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15623 · Cited by 1,805 · see citing works
Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes
Dalton, D. K., Pitts-Meek, S., Keshav, S., Figari, I. S., Bradley, A., & Stewart, T. A. (1993) · Science · doi:10.1126/science.8456300 · Cited by 1,733 · see citing works
Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656 · see citing works
Immune Response in Mice that Lack the Interferon-γ Receptor
Huang, S., Hendriks, W. J. A. J., Althage, A., Hemmi, S., Bluethmann, H., Kamijo, R., Vilček, J., Zinkernagel, R. M., & Aguet, M. (1993) · Science · doi:10.1126/science.8456301 · Cited by 1,551 · see citing works
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
Durbin, J. E., Hackenmiller, R., Simon, M. C., & Levy, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81289-1 · Cited by 1,522 · see citing works
Self-citationGrowth factor signaling by receptor tyrosine kinases
Schlessinger, J., & Ullrich, A. (1992) · Neuron · doi:10.1016/0896-6273(92)90177-f · Cited by 1,430 · see citing works
Takeda, K., Clausen, B. E., Kaisho, T., Tsujimura, T., Terada, N., Förster, I., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80005-9 · Cited by 1,220 · see citing works
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
Parganas, E., Wang, D., Stravopodis, D. J., Topham, D. J., Marine, J., Teglund, S., Vanin, E. F., Bodner, S. M., Colamonici, O. R., van Deursen, J. M., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81167-8 · Cited by 1,157 · see citing works
Marié, I., Durbin, J. E., & Levy, D. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6660 · Cited by 1,049 · see citing works
Self-citationTHE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling
Bach, E. A., Aguet, M., & Schreiber, R. D. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.563 · Cited by 1,033 · see citing works
Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems
García‐Sastre, A., Egorov, A., Matassov, D., Brandt, S., Levy, D. E., Durbin, J. E., Palese, P., & Muster, T. (1998) · Virology · doi:10.1006/viro.1998.9508 · Cited by 1,000 · see citing works
Self-citationInterferons: cell signalling, immune modulation, antiviral response and virus countermeasures
Goodbourn, S., Didcock, L., & Randall, R. E. (2000) · Journal of General Virology · doi:10.1099/0022-1317-81-10-2341 · Cited by 977 · see citing works
Rodig, S. J., Meraz‐Ríos, M. A., White, J. M., Lampe, P. A., Riley, J. K., Arthur, C. D., King, K. L., Sheehan, K. C. F., Li, Y., Pennica, D., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81166-6 · Cited by 857 · see citing works
PKR; a sentinel kinase for cellular stress
Williams, B. R. (1999) · Oncogene · doi:10.1038/sj.onc.1203127 · Cited by 820 · see citing works
Kerr, I. M., & Brown, R. E. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.1.256 · Cited by 794 · see citing works
Viral Strategies of Immune Evasion
Ploegh, H. L. (1998) · Science · doi:10.1126/science.280.5361.248 · Cited by 786 · see citing works
He, B., Gross, M., & Roizman, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.3.843 · Cited by 755 · see citing works
Inhibition of the Interferon- Inducible Protein Kinase PKR by HCV E2 Protein
Taylor, D. R., Shi, S. T., Romano, P. R., Barber, G. N., & Lai, M. M. C. (1999) · Science · doi:10.1126/science.285.5424.107 · Cited by 732 · see citing works
Matsuyama, T., Kimura, T., Kitagawa, M., Pfeffer, K., Kawakami, T., Watanabe, N., Kündig, T. M., Amakawa, R., Kishihara, K., Wakeham, A., et al. (1993) · Cell · doi:10.1016/s0092-8674(05)80086-8 · Cited by 649 · see citing works
Deficient signaling in mice devoid of double‐stranded RNA‐dependent protein kinase.
Yang, Y. L., Reis, L. F. L., Pavlovic, J., Aguzzi, A., Schäfer, R., Kumar, A., Williams, B. R. G., Aguet, M., & Weissmann, C. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00300.x · Cited by 632 · see citing works
Ronco, L. V., Karpova, A. Y., Vidal, M., & Howley, P. M. (1998) · Genes & Development · doi:10.1101/gad.12.13.2061 · Cited by 631 · see citing works
Gale, M., Blakely, C. M., Kwieciszewski, B., Tan, S., Dossett, M. L., Tang, N., Korth, M. J., Polyak, S. J., Gretch, D. R., & Katze, M. G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5208 · Cited by 606 · see citing works
Jacobs, B. L., & Langland, J. (1996) · Virology · doi:10.1006/viro.1996.0259 · Cited by 586 · see citing works
Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein
Talon, J., Horvath, C. M., Polley, R., Basler, C. F., Muster, T., Palese, P., & García‐Sastre, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.17.7989-7996.2000 · Cited by 578 · see citing works
Zhou, A., Paranjape, J., Brown, T. L., Nie, H., Naik, S., Dong, B., Chang, A., Trapp, B., Fairchild, R., Colmenares, C., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.21.6355 · Cited by 559 · see citing works
Positive feedback regulation of type I IFN genes by the IFN‐inducible transcription factor IRF‐7
Sato, M., Hata, N., Asagiri, M., Nakaya, T., Taniguchi, T., & Tanaka, N. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01514-2 · Cited by 553 · see citing works
Buchmeier, N. A., & Schreiber, R. D. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.21.7404 · Cited by 544 · see citing works
Bromberg, J., Horvath, C. M., Wen, Z., Schreiber, R. D., & Darnell, J. E., Jr. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7673 · Cited by 541 · see citing works
Xie, M.-H., Aggarwal, S., Ho, W.-H., Foster, J., Zhang, Z., Stinson, J., Wood, W. I., Goddard, A. D., & Gurney, A. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005304200 · Cited by 541 · see citing works
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.Preprint
Horvath, C. M., Wen, Z., & Darnell, J. E., Jr. (1995) · Genes & Development · doi:10.1101/gad.9.8.984 · Cited by 539 · see citing works
Influenza A Virus NS1 Protein Prevents Activation of NF-κB and Induction of Alpha/Beta Interferon
Wang, X., Li, M. O., Zheng, H., Muster, T., Palese, P., Beg, A. A., & García‐Sastre, A. (2000) · Journal of Virology · doi:10.1128/jvi.74.24.11566-11573.2000 · Cited by 536 · see citing works
Essential Role for the dsRNA-Dependent Protein Kinase PKR in Innate Immunity to Viral Infection
Balachandran, S., Roberts, P. C., Brown, L. E., Truong, H., Pattnaik, A. K., Archer, D. R., & Barber, G. N. (2000) · Immunity · doi:10.1016/s1074-7613(00)00014-5 · Cited by 527 · see citing works
Symons, J. A., Alcamı́, A., & Smith, G. L. (1995) · Cell · doi:10.1016/0092-8674(95)90076-4 · Cited by 491 · see citing works
Chang, H. W., Watson, J. C., & Jacobs, B. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.11.4825 · Cited by 484 · see citing works
The Ebola virus VP35 protein functions as a type I IFN antagonist
Basler, C. F., Wang, X., Mühlberger, E., Volchkov, V. E., Paragas, J., Klenk, H., García‐Sastre, A., & Palese, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220398297 · Cited by 477 · see citing works
Levy, D. E., Kessler, D. S., Pine, R. I., & Darnell, J. E., Jr. (1989) · Genes & Development · doi:10.1101/gad.3.9.1362 · Cited by 468 · see citing works
Self-citationGreenlund, A. C., Farrar, M. A., Viviano, B. L., & Schreiber, R. D. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06422.x · Cited by 454 · see citing works
GAS Elements: A Few Nucleotides with a Major Impact on Cytokine-Induced Gene Expression
DECKER, T., KOVARIK, P., & MEINKE, A. (1997) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1997.17.121 · Cited by 437 · see citing works
The E6 protein of human papillomavirus type 16 binds to and inhibits co‐activation by CBP and p300
Patel, D., Huang, S., Baglia, L. A., & McCance, D. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5061 · Cited by 429 · see citing works
Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice
Karaghiosoff, M., Neubauer, H. J., Lassnig, C., Kovarik, P., Schindler, H., Pircher, H., McCoy, B., Bogdan, C., Decker, T., Brem, G., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00054-6 · Cited by 422 · see citing works
Didcock, L., Young, D. F., Goodbourn, S., & Randall, R. E. (1999) · Journal of Virology · doi:10.1128/jvi.73.12.9928-9933.1999 · Cited by 422 · see citing works
Seidel, H. M., Milocco, L. H., Lamb, P., Darnell, J. E., Stein, R. B., & Rosen, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.3041 · Cited by 415 · see citing works
Adenovirus virus-associated RNA and translation control
Mathews, M. B., & Shenk, T. E. (1991) · Journal of Virology · doi:10.1128/jvi.65.11.5657-5662.1991 · Cited by 393 · see citing works
Wang, Z., Reiner, S. L., Zheng, S., Dalton, D. K., & Locksley, R. M. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1367 · Cited by 392 · see citing works
JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection
Chu, W., Ostertag, D. G., Li, Z.-W., Chang, L., Chen, Y., Hu, Y., Williams, B. R. G., Perrault, J., & Karin, M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80146-6 · Cited by 389 · see citing works
A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis
Der, S. D., Yang, Y.-L., Weissmann, C., & Williams, B. R. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3279 · Cited by 389 · see citing works
Gale, M., & Katze, M. G. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)00165-4 · Cited by 388 · see citing works
LU, Y., Wambach, M., Katze, M. G., & Krug, R. M. (1995) · Virology · doi:10.1006/viro.1995.9937 · Cited by 387 · see citing works
Colamonici, O. R., Domanski, P. J., Sweitzer, S. M., Larner, A. C., & Buller, R. M. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.27.15974 · Cited by 385 · see citing works
Balachandran, S., Kim, C. N., Yeh, W., Mak, T., Bhalla, K., & Barber, G. (1998) · EMBO Journal · doi:10.1093/emboj/17.23.6888 · Cited by 385 · see citing works
Hwang, S. Y., Hertzog, P. J., Holland, K. A., Sumarsono, S. H., Tymms, M. J., Hamilton, J. A., Whitty, G. A., Bertoncello, I., & Kola, I. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11284 · Cited by 378 · see citing works
Viral mechanisms of immune evasion
Alcamı́, A., Alcamı́, A., & Koszinowski, U. H. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01830-8 · Cited by 363 · see citing works
Influenza Virus NS1 Protein Counteracts PKR-Mediated Inhibition of Replication
Bergmann, M., Garcia-Sastre, A., Carnero, E., Pehamberger, H., Wolff, K., Palese, P., & Muster, T. (2000) · Journal of Virology · doi:10.1128/jvi.74.13.6203-6206.2000 · Cited by 362 · see citing works
Kumar, A., Yang, Y., Flati, V., Der, S., Kadereit, S., Deb, A., Haque, J., Reis, L. F. L., Weissmann, C., & Williams, B. R. G. (1997) · The EMBO Journal · doi:10.1093/emboj/16.2.406 · Cited by 350 · see citing works
Miller, D. M., Rahill, B. M., Boss, J. M., Lairmore, M. D., Durbin, J. E., Waldman, J., & Sedmak, D. D. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.5.675 · Cited by 337 · see citing works
Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach
Talon, J., Salvatore, M., O’Neill, R. E., Nakaya, Y., Zheng, H., Muster, T., García‐Sastre, A., & Palese, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.070525997 · Cited by 320 · see citing works
Regulation of c‐myc expression by IFN‐γ through Stat1‐dependent and ‐independent pathways
Ramana, C. V., Grammatikakis, N., Chernov, M., Nguyen, H., Goh, K. C., Williams, B. R. G., & Stark, G. R. (2000) · The EMBO Journal · doi:10.1093/emboj/19.2.263 · Cited by 320 · see citing works
Autoregulatory Mechanisms in Protein-tyrosine Kinases
Hubbard, S. R., Mohammadi, M., & Schlessinger, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.11987 · Cited by 317 · see citing works
Translational Control of Viral Gene Expression in Eukaryotes
Gale, M., Tan, S., & Katze, M. G. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.2.239-280.2000 · Cited by 316 · see citing works
Greenlund, A. C., Morales, M. O., Viviano, B. L., Yan, H., Krolewski, J. J., & Schreiber, R. D. (1995) · Immunity · doi:10.1016/1074-7613(95)90012-8 · Cited by 304 · see citing works
Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox
Nguyen, K. B., Cousens, L. P., Doughty, L., Pien, G. C., Durbin, J. E., & Biron, C. A. (2000) · Nature Immunology · doi:10.1038/76940 · Cited by 303 · see citing works
Au, W.-C., Moore, P. A., LaFleur, D. W., TOMBAL, B. F., & Pitha, P. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.29210 · Cited by 300 · see citing works
Influenza Virus-Susceptible Mice Carry Mx Genes with a Large Deletion or a Nonsense Mutation
Staeheli, P., Grob, R., Meier, E., Sutcliffe, J. G., & Haller, O. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.10.4518-4523.1988 · Cited by 294 · see citing works
The Role of Interferon in Influenza Virus Tissue Tropism
García‐Sastre, A., Durbin, R. K., Zheng, H., Palese, P., Gertner, R., Levy, D. E., & Durbin, J. E. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8550-8558.1998 · Cited by 286 · see citing works
Self-citationJuang, Y.-T., Lowther, W. J., Kellum, M. J., Au, W.-C., Lin, R., Hiscott, J. B., & Pitha, P. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9837 · Cited by 266 · see citing works
The Type I Interferon Receptor: Structure, Function, and Evolution of a Family Business
Mogensen, K. E., Lewerenz, M., Reboul, J., Lutfalla, G., & Uzé, G. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313019 · Cited by 252 · see citing works
Components of a stat recognition code: Evidence for two layers of molecular selectivity
Schindler, U., Wu, P., Rothe, M., Brasseur, M., & McKnight, S. L. (1995) · Immunity · doi:10.1016/1074-7613(95)90013-6 · Cited by 246 · see citing works
Interferon Action in Triply Deficient Mice Reveals the Existence of Alternative Antiviral Pathways
Zhou, A., Paranjape, J. M., Der, S. D., Williams, B. R. G., & Silverman, R. H. (1999) · Virology · doi:10.1006/viro.1999.9738 · Cited by 244 · see citing works
Swihart, K. G., Fruth, U., Messmer, N., Hug, K., Behin, R., Huang, S., Giudice, G. D., Aguet, M., & Louis, J. A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.3.961 · Cited by 244 · see citing works
Schlender, J., Bossert, B., Buchholz, U. J., & Conzelmann, K. (2000) · Journal of Virology · doi:10.1128/jvi.74.18.8234-8242.2000 · Cited by 242 · see citing works
Kimura, T., Kadokawa, Y., Harada, H., Matsumoto, M., Sato, M., Kashiwazaki, Y., Tarutani, M., Tan, R. S., Takasugi, T., Matsuyama, T., et al. (1996) · Genes to Cells · doi:10.1046/j.1365-2443.1996.08008.x · Cited by 233 · see citing works
Abraham, N. B., Stojdl, D. F., Duncan, P. I., Méthot, N., Ishii, T. M., Dubé, M., Vanderhyden, B. C., Atkins, H. L., Gray, D. A., McBurney, M. W., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.9.5953 · Cited by 231 · see citing works
Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene
Leib, D. A., Machalek, M. A., Williams, B. R. G., Silverman, R. H., & Virgin, H. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100415697 · Cited by 230 · see citing works
The Human Papillomavirus E7 Oncoprotein Abrogates Signaling Mediated by Interferon-α
Barnard, P., & McMillan, N. A. J. (1999) · Virology · doi:10.1006/viro.1999.9771 · Cited by 229 · see citing works
Zimring, J. C., Goodbourn, S., & Offermann, M. K. (1998) · Journal of Virology · doi:10.1128/jvi.72.1.701-707.1998 · Cited by 216 · see citing works
Davies, M. V., Elroy‐Stein, O., Jagus, R., Moss, B., & Kaufman, R. J. (1992) · Journal of Virology · doi:10.1128/jvi.66.4.1943-1950.1992 · Cited by 214 · see citing works
Yoshimura, A., Ichihara, M., Kinjyo, I., Moriyama, M., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Hara, T., & Miyajima, A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00443.x · Cited by 213 · see citing works
Imani, F., & Jacobs, B. L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.7887 · Cited by 205 · see citing works
Sendai Virus C Proteins Counteract the Interferon-Mediated Induction of an Antiviral State
Garcin, D., Latorre, P., & Kolakofsky, D. (1999) · Journal of Virology · doi:10.1128/jvi.73.8.6559-6565.1999 · Cited by 204 · see citing works
Paramyxoviridae Use Distinct Virus-Specific Mechanisms to Circumvent the Interferon Response
Young, D. F., Didcock, L., Goodbourn, S., & Randall, R. E. (2000) · Virology · doi:10.1006/viro.2000.0240 · Cited by 196 · see citing works
Yan, H., Krishnan, K., Greenlund, A. C., Gupta, S., Lim, J. L., Schreiber, R. D., Schindler, C., & Krolewski, J. (1996) · EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00444.x · Cited by 193 · see citing works
Cassady, K. A., Gross, M. S., & Roizman, B. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8620-8626.1998 · Cited by 189 · see citing works
Romano, P. R., Zhang, F., Tan, S., Garcia-Barrio, M. T., Katze, M. G., Dever, T. E., & Hinnebusch, A. G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7304 · Cited by 188 · see citing works
Reis, L. F. L., Ruffner, H., Stark, G., Aguet, M., & Weissmann, C. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06805.x · Cited by 184 · see citing works
Li, X., Leung, S., Kerr, I. M., & Stark, G. R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2048 · Cited by 181 · see citing works
Black, T. L., Safer, B., Hovanessian, A. G., & Katze, M. G. (1989) · Journal of Virology · doi:10.1128/jvi.63.5.2244-2251.1989 · Cited by 179 · see citing works
Hatada, E., Saito, S., & Fukuda, R. (1999) · Journal of Virology · doi:10.1128/jvi.73.3.2425-2433.1999 · Cited by 177 · see citing works
Lubyová, B., & Pitha, P. M. (2000) · Journal of Virology · doi:10.1128/jvi.74.17.8194-8201.2000 · Cited by 174 · see citing works
Powell, P. P., Dixon, L. K., & Parkhouse, R. M. E. (1996) · Journal of Virology · doi:10.1128/jvi.70.12.8527-8533.1996 · Cited by 171 · see citing works
Kaposi’s Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor
Li, M., Lee, H., Guo, J., Neipel, F., Ozato, K., Jung, J. U., Fleckenstein, B., Jae, & Jung, U. (1997) · Cited by 171 · see citing works
Hefti, H. P., Frese, M., Landis, H., Paolo, C. D., Aguzzi, A., Haller, O., & Pavlovic, J. (1999) · Journal of Virology · doi:10.1128/jvi.73.8.6984-6991.1999 · Cited by 168 · see citing works
Interferon-β is required for interferon-α production in mouse fibroblasts
Erlandsson, L., Blumenthal, R., Eloranta, M., Engel, H., Alm, G. V., Weiß, S., & Leanderson, T. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70086-7 · Cited by 166 · see citing works
Zsak, L., Lu, Z., Kutish, G. F., Neilan, J. G., & Rock, D. L. (1996) · Journal of Virology · doi:10.1128/jvi.70.12.8865-8871.1996 · Cited by 165 · see citing works
Direct Suppression of Stat1 Function during Adenoviral Infection
Look, D. C., Roswit, W. T., Frick, A. G., Alevy, Y. G., Dickhaus, D. M., Walter, M. J., & Holtzman, M. J. (1998) · Immunity · doi:10.1016/s1074-7613(00)80652-4 · Cited by 165 · see citing works
Raz, R., Durbin, J. E., & Levy, D. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)51096-1 · Cited by 164 · see citing works
Self-citationLee, T. G., Tomita, J., Hovanessian, A. G., & Katze, M. G. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.16.6208 · Cited by 163 · see citing works
Clarke, P. A., Schwemmle, M., Schickinger, J., Hilse, K., & Clemens, M. J. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.2.243 · Cited by 163 · see citing works
Miller, D. M., Zhang, Y., Rahill, B. M., Waldman, W. J., & Sedmak, D. D. (1999) · PubMed · Cited by 162 · see citing works
Naniche, D., Yeh, A., Eto, D. S., Manchester, M., Friedman, R. M., & Oldstone, M. B. A. (2000) · Journal of Virology · doi:10.1128/jvi.74.16.7478-7484.2000 · Cited by 159 · see citing works
Foster, G. R., Ackrill, A. M., Goldin, R. D., Kerr, I. M., Thomas, H. C., & Stark, G. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2888 · Cited by 158 · see citing works
A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function.
Mohr, I., & Gluzman, Y. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00853.x · Cited by 157 · see citing works
Control of the Interferon-Induced 68-Kilodalton Protein Kinase by the HIV-1 tat Gene Product
Roy, S., Katze, M. G., Parkin, N. T., Edery, I., Hovanessian, A. G., & Sonenberg, N. (1990) · Science · doi:10.1126/science.2180064 · Cited by 153 · see citing works
Bluyssen, H. R., & Levy, D. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4600 · Cited by 150 · see citing works
Self-citationVaccinia Virus E3L Protein Is an Inhibitor of the Interferon (IFN)-Induced 2-5A Synthetase Enzyme
Rivas, C., Gil, J., Mělková, Z., Estéban, M., & Díaz‐Guerra, M. (1998) · Virology · doi:10.1006/viro.1998.9072 · Cited by 149 · see citing works
Lee, C., Smith, E., Gimeno, R., Gertner, R., & Levy, D. E. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.3.1286 · Cited by 145 · see citing works
Self-citationLigand-Induced Assembly and Activation of the Gamma Interferon Receptor in Intact Cells
Bach, E. A., Tanner, J. W., Marsters, S., Ashkenazi, A., Aguet, M., Shaw, A. S., & Schreiber, R. D. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.3214 · Cited by 145 · see citing works
Takizawa, T., Ohashi, K., & Nakanishi, Y. (1996) · Journal of Virology · doi:10.1128/jvi.70.11.8128-8132.1996 · Cited by 142 · see citing works
Inhibition of Nuclear Factor κB Activation by a Virus-encoded IκB-like Protein
Revilla, Y., Callejo, M., Rodríguez, J. M., Culebras, E., Nogal, M. L., Salas, M. L., Viñuela, E., & Fresno, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5405 · Cited by 139 · see citing works
Activation of NF-κB by the dsRNA-dependent protein kinase, PKR involves the IκB kinase complex
Gil, J., Alcamı́, J., & Estéban, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203448 · Cited by 137 · see citing works
Veals, S. A., Maria, T. S., & Levy, D. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.196-206.1993 · Cited by 136 · see citing works
Self-citationTargeted disruption of the interferon-γ receptor 2 gene results in severe immune defects in mice
Lu, B., Ebensperger, C., Dembić, Z., Wang, Y., Kvatyuk, M., Lu, T., Coffman, R. L., Pestka, S., & Rothman, P. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8233 · Cited by 132 · see citing works
The role of interferon regulatory factors in the interferon system and cell growth control
Harada, H., Taniguchi, T., & Tanaka, N. (1998) · Biochimie · doi:10.1016/s0300-9084(99)80017-0 · Cited by 131 · see citing works
Gunnery, S., Rice, A. P., Robertson, H. D., & Mathews, M. B. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.22.8687 · Cited by 131 · see citing works
Enhanced virus resistance of transgenic mice expressing the human MxA protein
Pavlovic, J., Arzet, H. A., Hefti, H. P., Frese, M., Rost, D., Ernst, B., Kolb, E., Staeheli, P., & Haller, O. (1995) · Journal of Virology · doi:10.1128/jvi.69.7.4506-4510.1995 · Cited by 130 · see citing works
Gil, J., & Estéban, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203710 · Cited by 128 · see citing works
The Janus kinase family of protein tyrosine kinases and their role in signaling
Yeh, T. C., & Pellegrini, S. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050392 · Cited by 126 · see citing works
Steinhoff, U., Müller, U., Schertler, A., Hengartner, H., Aguet, M., & Zinkernagel, R. M. (1995) · Journal of Virology · doi:10.1128/jvi.69.4.2153-2158.1995 · Cited by 126 · see citing works
CAYLEY, P. J., DAVIES, J. A., McCullagh, K. G., & Kerr, I. M. (1984) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1984.tb08355.x · Cited by 125 · see citing works
Ferran, M. C., & Lucas-Lenard, J. M. (1997) · Journal of Virology · doi:10.1128/jvi.71.1.371-377.1997 · Cited by 123 · see citing works
Martinand‐Mari, C., Montavon, C., Salehzada, T., Silhol, M., Lebleu, B., & Bisbal, C. (1999) · Journal of Virology · doi:10.1128/jvi.73.1.290-296.1999 · Cited by 121 · see citing works
Sharp, T. V., Moonan, F., Romashko, A. M., Joshi, B., Barber, G. N., & Jagus, R. (1998) · Virology · doi:10.1006/viro.1998.9365 · Cited by 120 · see citing works
Shared architecture of hormone binding domains in type I and II interferon receptors
Bazán, J. F. (1990) · Cell · doi:10.1016/0092-8674(90)90182-e · Cited by 120 · see citing works
Activation of the Transcription Factor ISGF3 by Interferon-gamma
Matsumoto, M., Tanaka, N., Harada, H., Kimura, T., Yokochi, T., Kitagawa, M., Schindler, C., & Taniguchi, T. (1999) · Biological Chemistry · doi:10.1515/bc.1999.087 · Cited by 110 · see citing works
Tan, S., Gale, M., & Katze, M. G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2431 · Cited by 110 · see citing works
Kirchhoff, S., Koromilas, A. E., Schaper, F., Grashoff, M., Sonenberg, N., & Häuser, H. (1995) · PubMed · Cited by 110 · see citing works
Sendai Virus Blocks Alpha Interferon Signaling to Signal Transducers and Activators of Transcription
Komatsu, T., Takeuchi, K., Yokoo, J., Tanaka, Y., & Gotoh, B. (2000) · Journal of Virology · doi:10.1128/jvi.74.5.2477-2480.2000 · Cited by 108 · see citing works
Identification of an Interferon-γ Receptor α Chain Sequence Required for JAK-1 Binding
Kaplan, D. H., Greenlund, A. C., Tanner, J. W., Shaw, A. S., & Schreiber, R. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.1.9 · Cited by 105 · see citing works
Host-range restriction of vaccinia virus E3L-specific deletion mutants
Beattie, E., Kauffman, E. B., Martínez, H. B., Perkus, M. E., Jacobs, B. L., Paoletti, E., & Tartaglia, J. (1996) · Virus Genes · doi:10.1007/bf00370005 · Cited by 102 · see citing works
Farrar, M. A., Campbell, J. D., & Schreiber, R. D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.11706 · Cited by 102 · see citing works
Interferon-gamma induces receptor dimerization in solution and on cells.
Greenlund, A. C., Schreiber, R. D., Goeddel, D. V., & Pennica, D. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46817-7 · Cited by 101 · see citing works
Yeow, W.-S., Au, W.-C., Juang, Y., Fields, C. D., Dent, C. L., Gewert, D. R., & Pitha, P. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.9.6313 · Cited by 101 · see citing works
Gale, M., Tan, S., Wambach, M., & Katze, M. G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4172 · Cited by 98 · see citing works
Mx Transgenic Mice — Animal Models of Health
Arnheiter, H., Frese, M., Kambadur, R., Meier, E., & Haller, O. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-85208-4_8 · Cited by 95 · see citing works
Atreya, P. L., & Kulkarni, S. (1999) · Virology · doi:10.1006/viro.1999.9835 · Cited by 91 · see citing works
Levy, D. E., & Darnell, J. E., Jr. (1990) · PubMed · Cited by 90 · see citing works
Self-citationLangland, J. O., Pettiford, S. M., Jiang, B., & Jacobs, B. L. (1994) · Journal of Virology · doi:10.1128/jvi.68.6.3821-3829.1994 · Cited by 90 · see citing works
Mechanism of Inactivation of NF-κB by a Viral Homologue of IκBα
Tait, S. W. G., Reid, E., Greaves, D. R., Wileman, T. E., & Powell, P. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000320200 · Cited by 88 · see citing works
Leonard, G. T., & Sen, G. C. (1997) · Journal of Virology · doi:10.1128/jvi.71.7.5095-5101.1997 · Cited by 86 · see citing works
Garcin, D., Curran, J. A., & Kolakofsky, D. (2000) · Journal of Virology · doi:10.1128/jvi.74.19.8823-8830.2000 · Cited by 84 · see citing works
Polyak, S. J., Tang, N., Wambach, M., Barber, G. N., & Katze, M. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1702 · Cited by 83 · see citing works
Identification of the hepatitis B virus factor that inhibits expression of the beta interferon gene
Whitten, T. M., Quets, A. T., & Schloemer, R. H. (1991) · Journal of Virology · doi:10.1128/jvi.65.9.4699-4704.1991 · Cited by 81 · see citing works
HAIG, McInnes, C. J., Thomson, WOOD, BUNYAN, & Mercer, A. A. (1998) · Immunology · doi:10.1046/j.1365-2567.1998.00438.x · Cited by 80 · see citing works
Mulvey, M. A., Poppers, J., Ladd, A., & Mohr, I. (1999) · Journal of Virology · doi:10.1128/jvi.73.4.3375-3385.1999 · Cited by 78 · see citing works
Physiological significance of STAT proteins: investigations through gene disruption in vivo
Levy, D. (1999) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180050395 · Cited by 75 · see citing works
Self-citationYeung, M. C., Chang, D. L., Camantigue, R. E., & Lau, A. S. Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.11860 · Cited by 74 · see citing works
Kanda, K., Decker, T., Åman, P., Wahlström, M., von Gabain, A., & Kallin, B. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.4930 · Cited by 72 · see citing works
Pitha, P. M., Au, W. C., Lowther, W. J., Juang, Y.-T., Schafer, S. L., Burýšek, L., Hiscott, J. B., & Moore, P. A. (1998) · Biochimie · doi:10.1016/s0300-9084(99)80018-2 · Cited by 71 · see citing works
Martinand‐Mari, C., Salehzada, T., Silhol, M., Lebleu, B., & Bisbal, C. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2540248.x · Cited by 69 · see citing works
JAKs and STATs in invertebrate model organisms
Dearolf, C. R. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050397 · Cited by 69 · see citing works
Virus interception of cytokine-regulated pathways
Kalvakolanu, D. V. (1999) · Trends in Microbiology · doi:10.1016/s0966-842x(99)01476-6 · Cited by 63 · see citing works
Dever, T. E., Rajaraman, S., McLachlin, J. R., Lu, J., Fabian, J. R., Kimball, S. R., & Miller, L. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4164 · Cited by 60 · see citing works
Viral Inhibition of Interferon Signal Transduction
Cebulla, C. M., Miller, D. M., & Sedmak, D. D. (1999) · Intervirology · doi:10.1159/000053968 · Cited by 60 · see citing works
Weber, F., Haller, O., & Kochs, G. (2000) · Journal of Virology · doi:10.1128/jvi.74.1.560-563.2000 · Cited by 58 · see citing works
Novel functions of interferon-induced proteins
Sen, G. C. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0312 · Cited by 56 · see citing works
Åman, P., & von Gabain, A. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08090.x · Cited by 55 · see citing works
Interferons as a paradigm for cytokine signal transduction
Schindler, C., & Brutsaert, S. (1999) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180050391 · Cited by 52 · see citing works
Nadeau, O. W., Domanski, P. J., Усачева, А. М., Shahab Uddin, M. S., Platanias, L. C., Pitha, P. M., Raz, R., Levy, D. E., Majchrzak, B., Fish, E. N., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.7.4045 · Cited by 50 · see citing works
Self-citationThe polyoma virus T antigen interferes with interferon-inducible gene expression
Weihua, X., Ramanujam, S., Lindner, D. J., Kudaravalli, R. D., Freund, R., & Kalvakolanu, D. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1085 · Cited by 46 · see citing works
From interference to interferon: a brief historical introduction
Lindenmann, J.-M. (1982) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1982.0101 · Cited by 39 · see citing works
Sussman, M. D., Lu, Z., Kutish, G. F., Afonso, C. L., Roberts, P. C., & Rock, D. L. (1992) · Journal of Virology · doi:10.1128/jvi.66.9.5586-5589.1992 · Cited by 35 · see citing works
Simian Virus 40 Large-T Bypasses the Translational Block Imposed by the Phosphorylation of eIF-2α
Swaminathan, S., Rajan, P., Савинова, О. В., Jagus, R., & Thimmapaya, B. (1996) · Virology · doi:10.1006/viro.1996.0255 · Cited by 22 · see citing works
A novel translational regulation function for the simian virus 40 large-T antigen gene
Rajan, P., Swaminathan, S., Zhu, J., Cole, C. N., Barber, G. N., Tevethia, M. J., & Thimmapaya, B. (1995) · Journal of Virology · doi:10.1128/jvi.69.2.785-795.1995 · Cited by 21 · see citing works
Genetic Resistance to Influenza Virus in Wild Mice
Haller, O., Acklin, M., & Staeheli, P. (1986) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-71304-0_40 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201 · see citing works
Self-citationIFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex
Kotenko, S. V., Gallagher, G. E., Baurin, V. V., Lewis-Antes, A., Shen, M., Shah, N. K., Langer, J. A., Sheikh, F. G., Dickensheets, H. L., & Donnelly, R. P. (2002) · Nature Immunology · doi:10.1038/ni875 · Cited by 1,867 · see citing works
VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
Xu, L., Wang, Y., Han, K.-J., Li, L., Zhai, Z., & Shu, H. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.014 · Cited by 1,849 · see citing works
The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
Zhong, B., Yang, Y., Li, S., Wang, Y., Li, Y., Diao, F., Lei, C., He, X., Zhang, L., Tien, P., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.003 · Cited by 1,513 · see citing works
Viruses and interferon: a fight for supremacy
Katze, M. G., He, Y., & Gale, M. (2002) · Nature Reviews Immunology · doi:10.1038/nri888 · Cited by 1,419 · see citing works
O’Shea, J. J., Gadina, M., & Schreiber, R. D. (2002) · Cell · doi:10.1016/s0092-8674(02)00701-8 · Cited by 1,119 · see citing works
Takaoka, A., Hayakawa, S., Yanai, H., Stoiber, D., Negishi, H., Kikuchi, H., Sasaki, S., Imai, K., Shibue, T., Honda, K., et al. (2003) · Nature · doi:10.1038/nature01850 · Cited by 847 · see citing works
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655 · see citing works
Nguyen, K. B., Salazar‐Mather, T. P., Dalod, M., VanDeusen, J. B., Wei, X., Liew, F. Y., Caligiuri, M. A., Durbin, J. E., & Biron, C. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.8.4279 · Cited by 606 · see citing works
Interferon signalling network in innate defence
Takaoka, A., & Yanai, H. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00716.x · Cited by 586 · see citing works
Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4
Watford, W. T., Hissong, B. D., Bream, J. H., Kanno, Y., Muul, L. M., & O’Shea, J. J. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00211.x · Cited by 570 · see citing works
The Ebola Virus VP35 Protein Inhibits Activation of Interferon Regulatory Factor 3
Basler, C. F., Mikulasova, A., Martínez‐Sobrido, L., Paragas, J., Mühlberger, E., Bray, M., Klenk, H., Palese, P., & García‐Sastre, A. (2003) · Journal of Virology · doi:10.1128/jvi.77.14.7945-7956.2003 · Cited by 476 · see citing works
Inhibition of Retroviral RNA Production by ZAP, a CCCH-Type Zinc Finger Protein
Gao, G., Guo, X., & Goff, S. P. (2002) · Science · doi:10.1126/science.1074276 · Cited by 464 · see citing works
Ebola Virus VP24 Binds Karyopherin α1 and Blocks STAT1 Nuclear Accumulation
Reid, S. P., Leung, L. W., Hartman, A. L., Martinez, O., Shaw, M. L., Carbonnelle, C., Volchkov, V. E., Nichol, S. T., & Basler, C. F. (2006) · Journal of Virology · doi:10.1128/jvi.02349-05 · Cited by 463 · see citing works
DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway
Lau, L., Gray, E. E., Brunette, R. L., & Stetson, D. B. (2015) · Science · doi:10.1126/science.aab3291 · Cited by 450 · see citing works
Negishi, H., Taniguchi, T., & Yanai, H. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028423 · Cited by 447 · see citing works
Interferon-Lambda: A New Addition to an Old Family
Donnelly, R. P., & Kotenko, S. V. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0078 · Cited by 427 · see citing works
Pathogenesis and virulence of herpes simplex virus
Zhu, S., & Viejo‐Borbolla, A. (2021) · Virulence · doi:10.1080/21505594.2021.1982373 · Cited by 403 · see citing works
Zhang, J., Hu, M., Wang, Y., & Shu, H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.362608 · Cited by 390 · see citing works
Interferon Alfacon-1 Plus Corticosteroids in Severe Acute Respiratory Syndrome
Loutfy, M. R., Blatt, L. M., Siminovitch, K. A., Ward, S. E., Wolff, B., Lho, H., Pham, D. H., Deif, H., LaMere, E. A., Chang, M., et al. (2003) · JAMA · doi:10.1001/jama.290.24.3222 · Cited by 382 · see citing works
Influenza Virus PB1-F2 Protein Induces Cell Death through Mitochondrial ANT3 and VDAC1
Zamarin, D., García‐Sastre, A., Xiao, X., Wang, R., & Palese, P. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010004 · Cited by 376 · see citing works
Frieman, M. B., Ratia, K. M., Johnston, R. E., Mesecar, A. D., & Baric, R. S. (2009) · Journal of Virology · doi:10.1128/jvi.02220-08 · Cited by 370 · see citing works
Regulation of the type I IFN induction: a current view
Honda, K., Yanai, H., Takaoka, A., & Taniguchi, T. (2005) · International Immunology · doi:10.1093/intimm/dxh318 · Cited by 347 · see citing works
Wathelet, M. G., Orr, M., Frieman, M. B., & Baric, R. S. (2007) · Journal of Virology · doi:10.1128/jvi.00702-07 · Cited by 339 · see citing works
Zhao, C., Beaudenon, S. L., Kelley, M. L., Waddell, M. B., Yuan, W., Schulman, B. A., Huibregtse, J. M., & Krug, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402528101 · Cited by 325 · see citing works
Best, S. M., Morris, K. L., Shannon, J. G., Robertson, S. J., Mitzel, D., Park, G. S., Boer, E. F., Wolfinbarger, J. B., & Bloom, M. E. (2005) · Journal of Virology · doi:10.1128/jvi.79.20.12828-12839.2005 · Cited by 322 · see citing works
Banno, T., Gazel, A., & Blumenberg, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400642200 · Cited by 316 · see citing works
Induction of Antiviral Immunity by Double-Stranded RNA in a Marine Invertebrate
Robalino, J., Browdy, C. L., Prior, S., Metz, A., Parnell, P. G., Gross, P. S., & Warr, G. W. (2004) · Journal of Virology · doi:10.1128/jvi.78.19.10442-10448.2004 · Cited by 307 · see citing works
Lin, R.-J., Chang, B.-L., Yu, H.-P., Liao, C., & Lin, Y. (2006) · Journal of Virology · doi:10.1128/jvi.02714-05 · Cited by 286 · see citing works
Spiegel, M., Pichlmair, A., Martínez‐Sobrido, L., Cros, J. F., García‐Sastre, A., Haller, O., & Weber, F. (2005) · Journal of Virology · doi:10.1128/jvi.79.4.2079-2086.2005 · Cited by 279 · see citing works
A systematic approach to virus–virus interactions
DaPalma, T., Doonan, B. P., Trager, N., & Kasman, L. M. (2010) · Virus Research · doi:10.1016/j.virusres.2010.01.002 · Cited by 276 · see citing works
Donelan, N. R., Basler, C. F., & García‐Sastre, A. (2003) · Journal of Virology · doi:10.1128/jvi.77.24.13257-13266.2003 · Cited by 273 · see citing works
Lin, R., Noyce, R. S., Collins, S. E., Everett, R. D., & Mossman, K. L. (2004) · Journal of Virology · doi:10.1128/jvi.78.4.1675-1684.2004 · Cited by 268 · see citing works
Shaw, M. L., García‐Sastre, A., Palese, P., & Basler, C. F. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.5633-5641.2004 · Cited by 261 · see citing works
Solórzano, A., Webby, R. J., Lager, K. M., Janke, B. H., García‐Sastre, A., & Richt, J. A. (2005) · Journal of Virology · doi:10.1128/jvi.79.12.7535-7543.2005 · Cited by 255 · see citing works
Chang, T.-H., Liao, C., & Lin, Y. (2005) · Microbes and Infection · doi:10.1016/j.micinf.2005.06.014 · Cited by 235 · see citing works
Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man
Lim, J. K., Lisco, A., McDermott, D. H., Huynh, L., Ward, J. M., Johnson, B., Johnson, H., Pape, J., Foster, G. A., Krysztof, D. E., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000321 · Cited by 232 · see citing works
Mogensen, T. H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03047 · Cited by 225 · see citing works
West Nile Virus Inhibits the Signal Transduction Pathway of Alpha Interferon
Guo, J., Hayashi, J., & Seeger, C. (2005) · Journal of Virology · doi:10.1128/jvi.79.3.1343-1350.2005 · Cited by 219 · see citing works
The interferon antiviral response: from viral invasion to evasion
Grandvaux, N., tenOever, B. R., Servant, M. J., & Hiscott, J. B. (2002) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200206000-00008 · Cited by 216 · see citing works
Inverse Interference: How Viruses Fight the Interferon System
Weber, F., Kochs, G., & Haller, O. (2004) · Viral Immunology · doi:10.1089/vim.2004.17.498 · Cited by 212 · see citing works
Peter Simmonds, K., Tuplin, A., & Evans, D. J. (2004) · RNA · doi:10.1261/rna.7640104 · Cited by 203 · see citing works
Keeping NK cells in highly regulated antiviral warfare
Lee, S., Miyagi, T., & Biron, C. A. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.04.001 · Cited by 201 · see citing works
Viperin restricts chikungunya virus replication and pathology
Teng, T., Foo, S., Simamarta, D., Lum, F., Teo, T., Lulla, A., Yeo, N. K., Koh, E. G. L., Chow, A. L., Leo, Y., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63120 · Cited by 196 · see citing works
Role of Nucleoporin Induction in Releasing an mRNA Nuclear Export Block
Enninga, J., Levy, D. E., Blobel, G., & Fontoura, B. M. A. (2002) · Science · doi:10.1126/science.1067861 · Cited by 196 · see citing works
Self-citationTakeuchi, K., Kadota, S., Takeda, M., Miyajima, N., & Nagata, K. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00528-3 · Cited by 192 · see citing works
Lin, R.-J., Liao, C., Lin, E., & Lin, Y. (2004) · Journal of Virology · doi:10.1128/jvi.78.17.9285-9294.2004 · Cited by 191 · see citing works
Parasite immune evasion: a momentous molecular war
Schmid‐Hempel, P. (2008) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2008.02.011 · Cited by 186 · see citing works
Lei, C., Zhong, B., Zhang, Y., Zhang, J., Wang, S., & Shu, H. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.021 · Cited by 180 · see citing works
Gadotti, A. C., Deus, M. D. C., Telles, J. P., Wind, R., Goes, M., Ossoski, R. G. C., de Padua, A. M., de Noronha, L., Moreno-Amaral, A. N., Baena, C. P., et al. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198171 · Cited by 176 · see citing works
Wang, J., Oberley‐Deegan, R. E., Wang, S., Nikrad, M. P., Funk, C. J., Hartshorn, K. L., & Mason, R. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.3.1296 · Cited by 174 · see citing works
Kubota, T., Matsuoka, M., Chang, T.-H., Tailor, P. B., Sasaki, T., Tashiro, M., Kato, A., & Ozato, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804479200 · Cited by 174 · see citing works
Kash, J. C., Mühlberger, E., Carter, V., Grosch, M. N., Perwitasari, O., Proll, S. C., Thomas, M. J., Weber, F., Klenk, H. D., & Katze, M. G. (2006) · Journal of Virology · doi:10.1128/jvi.80.6.3009-3020.2006 · Cited by 172 · see citing works
Review: Enhancement and Diversification of IFN Induction by IRF-7-Mediated Positive Feedback
Levy, D. E., Marié, I., Smith, E., & Prakash, A. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452692 · Cited by 166 · see citing works
Self-citationAndrejeva, J., Young, D. F., Goodbourn, S., & Randall, R. E. (2002) · Journal of Virology · doi:10.1128/jvi.76.5.2159-2167.2002 · Cited by 166 · see citing works
Cancer stem cell mimicry for immune evasion and therapeutic resistance
Saw, P. E., Liu, Q., Wong, P., & Song, E. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.06.003 · Cited by 164 · see citing works
Horvath, C. M. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04425.x · Cited by 161 · see citing works
Frieman, M. B., Chen, J., Morrison, T. E., Whitmore, A., Funkhouser, W., Ward, J. M., Lamirande, E. W., Roberts, A., Heise, M., Subbarao, K., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000849 · Cited by 158 · see citing works
Novel functions of proteins encoded by viral stress-inducible genes
Sarkar, S. N., & Sen, G. C. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.07.007 · Cited by 157 · see citing works
SIKE is an IKKε/TBK1‐associated suppressor of TLR3‐ and virus‐triggered IRF‐3 activation pathways
Huang, J., Liu, T., Xu, L., Chen, D., Zhai, Z., & Shu, H. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600863 · Cited by 155 · see citing works
Bonnevie‐Nielsen, V., Field, L. L., Lu, S., Zheng, D., Li, M., Martensen, P. M., Nielsen, T. B., Beck‐Nielsen, H., Lau, Y., & Pociot, F. (2005) · The American Journal of Human Genetics · doi:10.1086/429391 · Cited by 155 · see citing works
O’farrell, C., Vaghefi, N., Cantonnet, M., Buteau, B., Boudinot, P., & Benmansour, A. (2002) · Journal of Virology · doi:10.1128/jvi.76.16.8040-8049.2002 · Cited by 153 · see citing works
Interferon regulatory factor family of transcription factors and regulation of oncogenesis
Takaoka, A., Tamura, T., & Taniguchi, T. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2007.00720.x · Cited by 150 · see citing works
In vitro inhibition of fish rhabdoviruses by Japanese flounder, Paralichthys olivaceus Mx
Caipang, C. M. A., Hırono, I., & Aoki, T. (2003) · Virology · doi:10.1016/j.virol.2003.08.040 · Cited by 147 · see citing works
Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3
Zhang, M., Tian, Y., Wang, R., Gao, D., Zhang, Y., Diao, F., Chen, D., Zhai, Z., & Shu, H. (2008) · Cell Research · doi:10.1038/cr.2008.277 · Cited by 144 · see citing works
Inducible Systemic RNA Silencing in Caenorhabditis elegans
Timmons, L., Tabara, H., Mello, C. C., & Fire, A. Z. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-01-0858 · Cited by 143 · see citing works
Rodriguez, J. J., Cruz, C. D., & Horvath, C. M. (2004) · Journal of Virology · doi:10.1128/jvi.78.10.5358-5367.2004 · Cited by 142 · see citing works
The porcine dendritic cell family
Summerfield, A., & McCullough, K. C. (2008) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2008.05.005 · Cited by 139 · see citing works
Regulation of IRF3 activation in human antiviral signaling pathways
Hamrashdi, M. A., & Brady, G. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115026 · Cited by 137 · see citing works
Inhibition of RNA Polymerase II Phosphorylation by a Viral Interferon Antagonist
Thomas-Rüddel, D. O., Blakqori, G., Wagner, V., Banholzer, M., Kessler, N., Elliott, R. M., Haller, O., & Weber, F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400938200 · Cited by 137 · see citing works
Shin, Y. C., Nakamura, H., Liang, X., Feng, P., Chang, H., Kowalik, T. F., & Jung, J. U. (2006) · Journal of Virology · doi:10.1128/jvi.80.5.2257-2266.2006 · Cited by 136 · see citing works
COVID-19 and the role of cytokines in this disease
Hasanvand, A. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-00992-2 · Cited by 135 · see citing works
Effects of Interferons and Viruses on Metabolism
Fritsch, S. D., & Weichhart, T. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00630 · Cited by 134 · see citing works
Jounai, K., Ikado, K., Sugimura, T., Ano, Y., Braun, J., & Fujiwara, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032588 · Cited by 133 · see citing works
Immune Modulation by Silencing IL-12 Production in Dendritic Cells Using Small Interfering RNA
Hill, J. A., Ichim, T. E., Kusznieruk, K. P., Li, M., Huang, X., Yan, X., Zhong, R., Cairns, E., Bell, D., & Min, W.-P. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.691 · Cited by 132 · see citing works
Paramyxovirus strategies for evading the interferon response
Gotoh, B., Komatsu, T., Takeuchi, K., & Yokoo, J. (2002) · Reviews in Medical Virology · doi:10.1002/rmv.357 · Cited by 131 · see citing works
Levy, D. E., Marié, I., & Prakash, A. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00011-0 · Cited by 130 · see citing works
Self-citationDiao, F., Li, S., Tian, Y., Zhang, M., Xu, L., Zhang, Y., Wang, R., Chen, D., Zhai, Z., Zhong, B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700544104 · Cited by 129 · see citing works
Shemesh, M., Aktepe, T. E., Deerain, J. M., McAuley, J., Audsley, M. D., David, C. T., Purcell, D. F. J., Urin, V., Hartmann, R., Moseley, G. W., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009800 · Cited by 129 · see citing works
Durai, P., Batool, M., Shah, M., & Choi, S. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.76 · Cited by 126 · see citing works
IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff
Paulson, M. S., Press, C., Smith, E., Tanese, N., & Levy, D. E. (2002) · Nature Cell Biology · doi:10.1038/ncb747 · Cited by 120 · see citing works
Self-citationISG15: a ubiquitin-like enigma
Chinh, T.-T. (2005) · Frontiers in bioscience · doi:10.2741/1730 · Cited by 118 · see citing works
Cytokine and Chemokine Networks: Pathways to Antiviral Defense
Salazar‐Mather, T. P., & Hokeness, K. L. (2007) · Springer eBooks · doi:10.1007/978-3-540-33397-5_2 · Cited by 117 · see citing works
Song, C., Krell, P. J., & Yoo, D. (2010) · Virology · doi:10.1016/j.virol.2010.08.025 · Cited by 115 · see citing works
Miller, L. C., Laegreid, W. W., Bono, J. L., Chitko-McKown, C. G., & Fox, J. M. (2004) · Archives of Virology · doi:10.1007/s00705-004-0377-9 · Cited by 115 · see citing works
Wang, X., Basler, C. F., Williams, B. R. G., Silverman, R. H., Palese, P., & García‐Sastre, A. (2002) · Journal of Virology · doi:10.1128/jvi.76.24.12951-12962.2002 · Cited by 112 · see citing works
Hepatitis delta virus inhibits alpha interferon signaling #
Pugnale, P., Pazienza, V., Guilloux, K., & Negro, F. (2008) · Hepatology · doi:10.1002/hep.22654 · Cited by 111 · see citing works
Shimizu, T., Hino, A., Tsutsumi, A., Park, Y. K., Watanabe, W., & Kurokawa, M. (2008) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020801900102 · Cited by 110 · see citing works
Dolin, H. H., Papadimos, T. J., Chen, X., & Pan, Z. K. (2019) · Microbiology Insights · doi:10.1177/1178636118825081 · Cited by 110 · see citing works
Modulation of STAT1 protein levels: a mechanism shaping CD8 T-cell responses in vivo
Gil, M. P., Salomon, R., Louten, J., & Biron, C. A. (2005) · Blood · doi:10.1182/blood-2005-07-2834 · Cited by 110 · see citing works
López, C. B., García‐Sastre, A., Williams, B. R. G., & Moran, T. M. (2003) · The Journal of Infectious Diseases · doi:10.1086/368381 · Cited by 109 · see citing works
Role of the adaptive immune response in sepsis
Brady, J., Horie, S., & Laffey, J. G. (2020) · Intensive Care Medicine Experimental · doi:10.1186/s40635-020-00309-z · Cited by 106 · see citing works
Feng, X., Petraglia, A. L., Chen, M. J., Byskosh, P. V., Boos, M. D., & Reder, A. T. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00182-0 · Cited by 106 · see citing works
Andrejeva, J., Poole, E. L., Young, D. F., Goodbourn, S., & Randall, R. E. (2002) · Journal of Virology · doi:10.1128/jvi.76.22.11379-11386.2002 · Cited by 106 · see citing works
The role of differential expression of human interferon-A genes in antiviral immunity
Génin, P., Vaccaro, A., & Civas, A. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.07.005 · Cited by 105 · see citing works
RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage
Castelló, A., Izquierdo, J. M., Welnowska, E., & Carrasco, L. (2009) · Journal of Cell Science · doi:10.1242/jcs.055988 · Cited by 105 · see citing works
Suppression of interferon-α signaling by hepatitis E virus
Dong, C., Zafrullah, M., Mixson-Hayden, T. R., Dai, X., Liang, J., Meng, J., & Kamili, S. (2011) · Hepatology · doi:10.1002/hep.25530 · Cited by 104 · see citing works
Dong, W., Wei, X., Zhang, F., Hao, J., Huang, F., Zhang, C., & Liang, W. P. (2014) · Scientific Reports · doi:10.1038/srep07237 · Cited by 103 · see citing works
3-Deazaneplanocin A induces massively increased interferon-α production in Ebola virus-infected mice
Bray, M., Raymond, J. L., Geisbert, T. W., & Baker, R. O. (2002) · Antiviral Research · doi:10.1016/s0166-3542(02)00018-9 · Cited by 103 · see citing works
Page, C., Goicochea, L., Matthews, K. L., Zhang, Y., Klover, P. J., Holtzman, M. J., Hennighausen, L. G., & Frieman, M. B. (2012) · Journal of Virology · doi:10.1128/jvi.01689-12 · Cited by 102 · see citing works
- Authors
- Levy, D.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- Levy, D
- ORCID
- Levy, D
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 12
- Issue
- 2-3
- Pages
- 143-156
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W2043064608
- Cited by
- 428
- References
- 168
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 9 · 2023: 15 · 2022: 16 · 2021: 9 · 2020: 14 · 2019: 10 · 2018: 7 · 2017: 14 · 2016: 16 · 2015: 13 · 2014: 18 · 2013: 17 · 2012: 17
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ai046594-05)
- National Institute of Allergy and Infectious Diseases (AI48204, R01AI046503, AI 28900, AI46594, P01AI048204, AI46503, R01AI028900)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- interferon, antiviral state, viral evasion, innate immunity, interferon signaling, cytokine-cytokine receptor interaction, antiviral gene expression, host-virus coevolution, antiviral agents
- MeSH terms
- Animals, Antiviral Agents, DNA-Binding Proteins, Gene Expression Regulation, Humans, Interferons, Protein-Tyrosine Kinases, RNA, Double-Stranded, Viruses, Signal Transduction, Trans-Activators, Receptors, Interferon, eIF-2 Kinase, STAT1 Transcription Factor, Mice, Janus Kinase 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review