The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3
Abstract
Distal limb development and specification of digit identities in tetrapods are under the control of a mesenchymal organizer called the polarizing region. Sonic Hedgehog (SHH) is the morphogenetic signal produced by the polarizing region in the posterior limb bud. Ectopic anterior SHH signaling induces digit duplications and has been suspected as a major cause underlying congenital malformations that result in digit polydactyly. Here, we report that the polydactyly of Gli3 -deficient mice arises independently of SHH signaling. Disruption of one or both Gli3 alleles in mouse embryos lacking Shh progressively restores limb distal development and digit formation. Our genetic analysis indicates that SHH signaling counteracts GLI3-mediated repression of key regulator genes, cell survival, and distal progression of limb bud development.
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Cites
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
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Molecular Models for Vertebrate Limb Development
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Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3
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Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds
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Self-citationManifestation of the limb prepattern: limb development in the absence of sonic hedgehog function.
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Patterning Mechanisms Controlling Vertebrate Limb Development
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When cilia go bad: cilia defects and ciliopathies
Fliegauf, M., Benzing, T., & Omran, H. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2278 · Cited by 1,257
Haycraft, C. J., Banizs, B., Aydin-Son, Y., Zhang, Q., Michaud, E. J., & Yoder, B. K. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010053 · Cited by 902
Weston, A. D., & Hood, L. (2004) · Journal of Proteome Research · doi:10.1021/pr0499693 · Cited by 731
The Primary Cilium as a Complex Signaling Center
Berbari, N. F., O'Connor, A. K., Haycraft, C. J., & Yoder, B. K. (2009) · Current Biology · doi:10.1016/j.cub.2009.05.025 · Cited by 621
Liu, A., Wang, B., & Niswander, L. A. (2005) · Development · doi:10.1242/dev.01894 · Cited by 494
Metadata
- Authors
- te Welscher, P., Zuniga, A., Kuijper, S., Drenth, T., Goedemans, H. J., Meijlink, F., & Zeller, R.
- Venue
- Science
- Published
- 2002-10-25
- Volume
- 298
- Issue
- 5594
- Pages
- 827-830
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2147817030
- Cited by
- 375
- References
- 25
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- te Welscher, P., Zuniga, A., Kuijper, S., Drenth, T., Goedemans, H. J., Meijlink, F., & Zeller, R. (2002). Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3. Science. https://doi.org/10.1126/science.1075620
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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