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Structural Basis of Transcription Activation: The CAP-αCTD-DNA Complex
Abstract
The Escherichia coli catabolite activator protein (CAP) activates transcription at P lac , P gal , and other promoters through interactions with the RNA polymerase α subunit carboxyl-terminal domain (αCTD). We determined the crystal structure of the CAP-αCTD-DNA complex at a resolution of 3.1 angstroms. CAP makes direct protein-protein interactions with αCTD, and αCTD makes direct protein-DNA interactions with the DNA segment adjacent to the DNA site for CAP. There are no large-scale conformational changes in CAP and αCTD, and the interface between CAP and αCTD is small. These findings are consistent with the proposal that activation involves a simple “recruitment” mechanism.
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Citations
Cites
Transcriptional activation by recruitment
Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158
Cited by
rRNA Transcription in Escherichia coli
Paul, B. J., Ross, W., Gaal, T., & Gourse, R. L. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.091347 · Cited by 336
Catabolite activator protein: DNA binding and transcription activation
Lawson, C. L., Swigon, D., Murakami, K. S., Darst, S. A., Berman, H. M., & Ebright, R. H. (2004) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2004.01.012 · Cited by 330
Self-citationAdvances in bacterial promoter recognition and its control by factors that do not bind DNA
Haugen, S. P., Ross, W., & Gourse, R. L. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1912 · Cited by 320
Kuhn, M. L., Zemaitaitis, B., Hu, L. I., Sahu, A., Sorensen, D., Minasov, G., Lima, B. P., Scholle, M., Mrksich, M., Anderson, W. F., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094816 · Cited by 268
Bervoets, I., & Charlier, D. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz001 · Cited by 180
Metadata
- Authors
- Benoff, B., Yang, H., Lawson, C. L., Parkinson, G., Liu, J., Blatter, E., Ebright, Y. W., Berman, H. M., & Ebright, R. H.
- Venue
- Science
- Published
- 2002-08-30
- Volume
- 297
- Issue
- 5586
- Pages
- 1562-1566
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981577753
- Cited by
- 246
- References
- 1
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Benoff, B., Yang, H., Lawson, C. L., Parkinson, G., Liu, J., Blatter, E., Ebright, Y. W., Berman, H. M., & Ebright, R. H. (2002). Structural Basis of Transcription Activation: The CAP-αCTD-DNA Complex. Science. https://doi.org/10.1126/science.1076376
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