The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
A Role for the Protease Falcipain 1 in Host Cell Invasion by the Human Malaria Parasite
Abstract
Cysteine proteases of Plasmodium falciparum are required for survival of the malaria parasite, yet their specific cellular functions remain unclear. We used a chemical proteomic screen with a small-molecule probe to characterize the predominant cysteine proteases throughout the parasite life cycle. Only one protease, falcipain 1, was active during the invasive merozoite stage. Falcipain 1–specific inhibitors, identified by screening of chemical libraries, blocked parasite invasion of host erythrocytes, yet had no effect on normal parasite processes such as hemoglobin degradation. These results demonstrate a specific role for falcipain 1 in host cell invasion and establish a potential new target for antimalarial therapeutics.
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Cites
Cluster analysis and display of genome-wide expression patterns
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Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools
Greenbaum, D., Medzihradszky, K. F., Burlingame, A., & Bogyo, M. (2000) · Chemistry & Biology · doi:10.1016/s1074-5521(00)00014-4 · Cited by 581
Self-citationChromosome 2 Sequence of the Human Malaria Parasite Plasmodium falciparum
Gardner, M. J., Tettelin, H., Carucci, D. J., Cummings, L. M., Aravind, L., Koonin, E. V., Shallom, S., Mason, T., Yu, K., Fujii, C., et al. (1998) · Science · doi:10.1126/science.282.5391.1126 · Cited by 454
Cysteine Protease Inhibitors Cure an Experimental Trypanosoma cruzi Infection
Engel, J. C., Doyle, P. S., Hsieh, I., & McKerrow, J. H. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.4.725 · Cited by 392
Self-citationShenai, B. R., Sijwali, P. S., Singh, A., & Rosenthal, P. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004459200 · Cited by 344
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum
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The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum
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Chemical Approaches for Functionally Probing the Proteome
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Self-citationExpression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3
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Cited by
Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry
Cravatt, B. F., Wright, A. T., & Kozarich, J. W. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.101304.124125 · Cited by 1,270
Sijwali, P. S., & Rosenthal, P. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307720101 · Cited by 276
Bachovchin, D. A., Ji, T., Li, W., Simon, G. M., Blankman, J. L., Adibekian, A., Hoover, H., Niessen, S., & Cravatt, B. F. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011663107 · Cited by 274
How Chemoproteomics Can Enable Drug Discovery and Development
Moellering, R. E., & Cravatt, B. F. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.01.001 · Cited by 182
Metadata
- Authors
- Greenbaum, D. C., Baruch, A., Grainger, M., Bozdech, Z., Medzihradszky, K. F., Engel, J., DeRisi, J., Holder, A. A., & Bogyo, M.
- Venue
- Science
- Published
- 2002-12-06
- Volume
- 298
- Issue
- 5600
- Pages
- 2002-2006
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2040856541
- Cited by
- 288
- References
- 18
- FWCI
- 22.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Greenbaum, D. C., Baruch, A., Grainger, M., Bozdech, Z., Medzihradszky, K. F., Engel, J., DeRisi, J., Holder, A. A., & Bogyo, M. (2002). A Role for the Protease Falcipain 1 in Host Cell Invasion by the Human Malaria Parasite. Science. https://doi.org/10.1126/science.1077426
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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