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Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation
Abstract
Recently, we showed that antibodies catalyze the generation of hydrogen peroxide (H 2 O 2 ) from singlet molecular oxygen ( 1 O 2 *) and water. Here, we show that this process can lead to efficient killing of bacteria, regardless of the antigen specificity of the antibody. H 2 O 2 production by antibodies alone was found to be not sufficient for bacterial killing. Our studies suggested that the antibody-catalyzed water-oxidation pathway produced an additional molecular species with a chemical signature similar to that of ozone. This species is also generated during the oxidative burst of activated human neutrophils and during inflammation. These observations suggest that alternative pathways may exist for biological killing of bacteria that are mediated by potent oxidants previously unknown to biology.
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Citations
Cited by
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125
Myeloperoxidase: friend and foe
Klebanoff, S. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204697 · Cited by 2,282
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
Fang, F. C. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1004 · Cited by 1,676
Graves, D. B. (2012) · Journal of Physics D: Applied Physics · doi:10.1088/0022-3727/45/26/263001 · Cited by 1,518
Fluorescent and luminescent probes for detection of reactive oxygen and nitrogen species
Chen, X., Tian, X., Shin, I., & Yoon, J. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15037e · Cited by 980
Metadata
- Authors
- Wentworth, P., McDunn, J. E., Wentworth, A. D., Takeuchi, C., Nieva, J., Jones, T., Bautista, C., Ruedi, J. M., Gutierrez, A., Janda, K. D., Babior, B. M., Eschenmoser, A., & Lerner, R. A.
- Venue
- Science
- Published
- 2002-12-13
- Volume
- 298
- Issue
- 5601
- Pages
- 2195-2199
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2102540369
- Cited by
- 349
- References
- 0
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation. https://app.cochat.ai/papers/10.1126/science.1077642
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- Wentworth, P., McDunn, J. E., Wentworth, A. D., Takeuchi, C., Nieva, J., Jones, T., Bautista, C., Ruedi, J. M., Gutierrez, A., Janda, K. D., Babior, B. M., Eschenmoser, A., & Lerner, R. A. (2002). Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation. Science. https://doi.org/10.1126/science.1077642
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
