The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Dissecting Apicoplast Targeting in the Malaria Parasite Plasmodium falciparum
Abstract
Transit peptides mediate protein targeting into plastids and are only poorly understood. We extracted amino acid features from transit peptides that target proteins to the relict plastid (apicoplast) of malaria parasites. Based on these amino acid characteristics, we identified 466 putative apicoplast proteins in the Plasmodium falciparum genome. Altering the specific charge characteristics in a model transit peptide by site-directed mutagenesis severely disrupted organellar targeting in vivo. Similarly, putative Hsp70 (DnaK) binding sites present in the transit peptide proved to be important for correct targeting.
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Cites
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Genome sequence of the human malaria parasite Plasmodium falciparum
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Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
Waller, R. F., Keeling, P. J., Donald, R. G. K., Striepen, B., Handman, E., Lang-Unnasch, N., Cowman, A. F., Besra, G. S., Roos, D. S., & McFadden, G. I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12352 · Cited by 714
Self-citationComplete Gene Map of the Plastid-like DNA of the Malaria ParasitePlasmodium falciparum
Wilson, (. R. J. M., Denny, P. W., Preiser, P. R., Rangachari, K., Roberts, K., Roy, A., Whyte, A., Strath, M., Moore, D. J., Moore, P. W., et al. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0449 · Cited by 575
Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway
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Cited by
Biosynthesis of isoprenoids via the non-mevalonate pathway
Eisenreich, W., Bacher, A., Arigoni, D., & Rohdich, F. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-3381-z · Cited by 668
Ward, P., Equinet, L., Packer, J., & Doerig, C. (2004) · BMC Genomics · doi:10.1186/1471-2164-5-79 · Cited by 507
The Origin and Establishment of the Plastid in Algae and Plants
Reyes-Prieto, A., Weber, A. P. M., & Bhattacharya, D. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130134 · Cited by 453
Diversity and evolutionary history of plastids and their hosts
Keeling, P. J. (2004) · American Journal of Botany · doi:10.3732/ajb.91.10.1481 · Cited by 455
The evolution, metabolism and functions of the apicoplast
Lim, L., & McFadden, G. I. (2010) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2009.0273 · Cited by 356
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Metadata
- Authors
- Foth, B. J., Ralph, S. A., Tonkin, C. J., Struck, N. S., Fraunholz, M., Roos, D. S., Cowman, A. F., & McFadden, G. I.
- Venue
- Science
- Published
- 2003-01-31
- Volume
- 299
- Issue
- 5607
- Pages
- 705-708
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2134213012
- Cited by
- 458
- References
- 24
- FWCI
- 35.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Foth, B. J., Ralph, S. A., Tonkin, C. J., Struck, N. S., Fraunholz, M., Roos, D. S., Cowman, A. F., & McFadden, G. I. (2003). Dissecting Apicoplast Targeting in the Malaria Parasite Plasmodium falciparum. Science. https://doi.org/10.1126/science.1078599
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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