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Role of EphA4 and EphrinB3 in Local Neuronal Circuits That Control Walking
Abstract
Local circuits in the spinal cord that generate locomotion are termed central pattern generators (CPGs). These provide coordinated bilateral control over the normal limb alternation that underlies walking. The molecules that organize the mammalian CPG are unknown. Isolated spinal cords from mice lacking either the EphA4 receptor or its ligand ephrinB3 have lost left-right limb alternation and instead exhibit synchrony. We identified EphA4-positive neurons as an excitatory component of the locomotor CPG. Our study shows that dramatic locomotor changes can occur as a consequence of local genetic rewiring and identifies genes required for the development of normal locomotor behavior.
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Citations
Cited by
Circuits controlling vertebrate locomotion: moving in a new direction
Goulding, M. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2608 · Cited by 777
“Mice lacking the receptor tyrosine kinase Epha4 , its ligand ephrin B3 , or the Nck adaptor protein also exhibit a loss of left–right alternatio”
BackgroundV1 spinal neurons regulate the speed of vertebrate locomotor outputs
Gosgnach, S., Lanuza, G. M., Butt, S. J. B., Saueressig, H., Zhang, Y., Velasquez, T., Riethmacher, D., Callaway, E. M., Kiehn, O., & Goulding, M. (2006) · Nature · doi:10.1038/nature04545 · Cited by 405
Self-citationKimura, Y., Okamura, Y., & Higashijima, S.-I. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4993-05.2006 · Cited by 302
“Recently, it has been shown that neurons that express the EphA4 tyrosine kinase receptor are important for mammalian locomotion (Kullander et al., 2003) and that a subset of these neurons excite motoneurons on the same side (Butt et al.”
BackgroundIn mice lacking V2a interneurons, gait depends on speed of locomotion
Crone, S. A., Zhong, G., Harris-Warrick, R., & Sharma, K. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1206-09.2009 · Cited by 263
Bellardita, C., & Kiehn, O. (2015) · Current Biology · doi:10.1016/j.cub.2015.04.005 · Cited by 263
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Metadata
- Authors
- Kullander, K., Butt, S. J. B., Lebret, J. M., Lundfald, L., Restrepo, C. E., Rydström, A., Klein, R., & Kiehn, O.
- Venue
- Science
- Published
- 2003-03-21
- Volume
- 299
- Issue
- 5614
- Pages
- 1889-1892
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2035937362
- Cited by
- 330
- References
- 0
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kullander, K., Butt, S. J. B., Lebret, J. M., Lundfald, L., Restrepo, C. E., Rydström, A., Klein, R., & Kiehn, O. (2003). Role of EphA4 and EphrinB3 in Local Neuronal Circuits That Control Walking. Science. https://doi.org/10.1126/science.1079641
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
