The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Synaptic Plasticity in Spinal Lamina I Projection Neurons That Mediate Hyperalgesia
Abstract
Inflammation, trauma, or nerve injury may cause enduring hyperalgesia, an enhanced sensitivity to painful stimuli. Neurons in lamina I of the spinal dorsal horn that express the neurokinin 1 receptor for substance P mediate this abnormal pain sensitivity by an unknown cellular mechanism. We report that in these, but not in other nociceptive lamina I cells, neurokinin 1 receptor–activated signal transduction pathways and activation of low-threshold (T-type) voltage-gated calcium channels synergistically facilitate activity- and calcium-dependent long-term potentiation at synapses from nociceptive nerve fibers. Thereby, memory traces of painful events are retained.
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Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Neuronal plasticity: Increasing the gain in pain
Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781
Cited by
Central sensitization: implications for the diagnosis and treatment of pain
Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771
Central sensitization: a generator of pain hypersensitivity by central neural plasticity
Latremoliere, A., & Woolf, C. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.012 · Cited by 3,913
Neuronal circuitry for pain processing in the dorsal horn
Todd, A. J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2947 · Cited by 1,475
Models and Mechanisms of Hyperalgesia and Allodynia
Sandkühler, J. (2009) · Physiological Reviews · doi:10.1152/physrev.00025.2008 · Cited by 1,148
The development of nociceptive circuits
Fitzgerald, M. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1701 · Cited by 778
Metadata
- Authors
- Ikeda, H., Heinke, B., Ruscheweyh, R., & Sandkühler, J.
- Venue
- Science
- Published
- 2003-02-21
- Volume
- 299
- Issue
- 5610
- Pages
- 1237-1240
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979675387
- Cited by
- 569
- References
- 2
- FWCI
- 23.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ikeda, H., Heinke, B., Ruscheweyh, R., & Sandkühler, J. (2003). Synaptic Plasticity in Spinal Lamina I Projection Neurons That Mediate Hyperalgesia. Science. https://doi.org/10.1126/science.1080659
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
