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"Plugging into Enzymes": Nanowiring of Redox Enzymes by a Gold Nanoparticle
Abstract
The reconstitution of an apo-flavoenzyme, apo–glucose oxidase, on a 1.4-nanometer gold nanocrystal functionalized with the cofactor flavin adenine dinucleotide and integrated into a conductive film yields a bioelectrocatalytic system with exceptional electrical contact with the electrode support. The electron transfer turnover rate of the reconstituted bioelectrocatalyst is ∼5000 per second, compared with the rate at which molecular oxygen, the natural cosubstrate of the enzyme, accepts electrons (∼700 per second). The gold nanoparticle acts as an electron relay or “electrical nanoplug” for the alignment of the enzyme on the conductive support and for the electrical wiring of its redox-active center.
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Citations
Cited by
Electrochemical Glucose Biosensors
Wang, J. (2008) · Chemical Reviews · doi:10.1021/cr068123a · Cited by 3,498
Electrochemical Biosensors - Sensor Principles and Architectures
Grieshaber, D., MacKenzie, R., Vörös, J., & Reimhult, E. (2008) · Sensors · doi:10.3390/s80314000 · Cited by 2,329
Electrochemical Glucose Sensors and Their Applications in Diabetes Management
Heller, A., & Feldman, B. (2008) · Chemical Reviews · doi:10.1021/cr068069y · Cited by 1,707
Applications of Nanoparticles in Biology
De, M., Ghosh, P. S., & Rotello, V. M. (2008) · Advanced Materials · doi:10.1002/adma.200703183 · Cited by 1,547
Gold nanoparticle-based electrochemical biosensors
Pingarrón, J. M., Yáñez-Sedeño, P., & González-Cortés, A. (2008) · Electrochimica Acta · doi:10.1016/j.electacta.2008.03.005 · Cited by 965
Metadata
- Authors
- Xiao, Y., Patolsky, F., Katz, E., Hainfeld, J. F., & Willner, I.
- Venue
- Science
- Published
- 2003-03-21
- Volume
- 299
- Issue
- 5614
- Pages
- 1877-1881
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059559745
- Cited by
- 1,270
- References
- 0
- FWCI
- 66.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xiao, Y., Patolsky, F., Katz, E., Hainfeld, J. F., & Willner, I. (2003). "Plugging into Enzymes": Nanowiring of Redox Enzymes by a Gold Nanoparticle. Science. https://doi.org/10.1126/science.1080664
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
