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Disruption of the Epithelial Apical-Junctional Complex by Helicobacter pylori CagA
Open accessAbstract
Helicobacter pylori translocates the protein CagA into gastric epithelial cells and has been linked to peptic ulcer disease and gastric carcinoma. We show that injected CagA associates with the epithelial tight-junction scaffolding protein ZO-1 and the transmembrane protein junctional adhesion molecule, causing an ectopic assembly of tight-junction components at sites of bacterial attachment, and altering the composition and function of the apical-junctional complex. Long-term CagA delivery to polarized epithelia caused a disruption of the epithelial barrier function and dysplastic alterations in epithelial cell morphology. CagA appears to target H. pylori to host cell intercellular junctions and to disrupt junction-mediated functions.
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Cited by
Intestinal permeability – a new target for disease prevention and therapy
Bischoff, S. C., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J.-D., Serino, M., Tilg, H., Watson, A., & Wells, J. M. (2014) · BMC Gastroenterology · doi:10.1186/s12876-014-0189-7 · Cited by 1,755
Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk
Wroblewski, L. E., Peek, R. M., & Wilson, K. T. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00011-10 · Cited by 1,442
Mucin dynamics and enteric pathogens
McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2538 · Cited by 1,428
Helicobacter pylori: gastric cancer and beyond
Polk, D. B., & Peek, R. M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2857 · Cited by 1,158
Host-Bacterial Interactions in Helicobacter pylori Infection
Amieva, M. R., & El–Omar, E. M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.009 · Cited by 632
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Metadata
- Authors
- Amieva, M. R., Vogelmann, R., Covacci, A., Tompkins, L. S., Nelson, W. J., & Falkow, S.
- Venue
- Science
- Published
- 2003-05-30
- Volume
- 300
- Issue
- 5624
- Pages
- 1430-1434
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994975655
- Cited by
- 740
- References
- 0
- FWCI
- 47.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Amieva, M. R., Vogelmann, R., Covacci, A., Tompkins, L. S., Nelson, W. J., & Falkow, S. (2003). Disruption of the Epithelial Apical-Junctional Complex by Helicobacter pylori CagA. Science. https://doi.org/10.1126/science.1081919
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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