Intestinal permeability – a new target for disease prevention and therapy

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works

Diversity of the Human Intestinal Microbial Flora

Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works

Enterotypes of the human gut microbiome

MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204 · see citing works

Changes of Intestinal Functions in Liver Cirrhosis

Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works

A metagenome-wide association study of gut microbiota in type 2 diabetes

Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works

The gut microbiota as an environmental factor that regulates fat storage

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works

Host-Bacterial Mutualism in the Human Intestine

Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works

Functional interactions between the gut microbiota and host metabolism

Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works

Abdominal obesity and metabolic syndrome

Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354 · see citing works

Interactions Between the Microbiota and the Immune System

Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173 · see citing works

Intestinal mucosal barrier function in health and disease

Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952 · see citing works

Of Mice and Not Men: Differences between Mouse and Human Immunology

Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822 · see citing works

Evolution of mammals and their gut microbes

Ley, R. E., Hamady, M., Lozupone, C., Turnbaugh, P. J., Ramey, R. R., Bircher, J. S., Schlegel, M. L., Tucker, T. A., Schrenzel, M. D., Knight, R., et al. (2008) · Science · doi:10.1126/science.1155725 · Cited by 3,747 · see citing works

Type 2 diabetes as an inflammatory disease

Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737 · see citing works

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241 · see citing works

Hepatogastroenterology

Chen, L., Li, N., & Ye, H. (2012) · Hepatogastroenterology · doi:10.5754/hge12469 · Cited by 3,199 · see citing works

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works

Multifunctional strands in tight junctions

Tsukita, S., Furuse, M., & Itoh, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35067088 · Cited by 2,514 · see citing works

Intestinal inflammation targets cancer-inducing activity of the microbiota

Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263 · see citing works

A decrease of the butyrate-producing species <i>Roseburia hominis</i> and <i>Faecalibacterium prausnitzii</i> defines dysbiosis in patients with ulcerative colitis

Machiels, K., Joossens, M., Sabino, J., De Preter, V., Arijs, I., Eeckhaut, V., Ballet, V., Claes, K., Van Immerseel, F., Verbeke, K., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-304833 · Cited by 1,904 · see citing works

Intestinal barrier function: molecular regulation and disease pathogenesis

Groschwitz, K. R., & Hogan, S. P. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.038 · Cited by 1,775 · see citing works

Reciprocal interactions of the intestinal microbiota and immune system

Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012) · Nature · doi:10.1038/nature11551 · Cited by 1,598 · cited 1× · see citing works

Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial

Gionchetti, P., Rizzello, F., Venturi, A., Brigidi, P., Matteuzzi, D., Bazzocchi, G., Poggioli, G., Miglioli, M., & Campieri, M. (2000) · Gastroenterology · doi:10.1053/gast.2000.9370 · Cited by 1,485 · see citing works

Immune adaptations that maintain homeostasis with the intestinal microbiota

Hooper, L. V., & Macpherson, A. J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2710 · Cited by 1,455 · see citing works

Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress

Kim, Y. S., & Ho, S. B. (2010) · Current Gastroenterology Reports · doi:10.1007/s11894-010-0131-2 · Cited by 1,437 · see citing works

Mucin dynamics and enteric pathogens

McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2538 · Cited by 1,428 · see citing works

The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine

Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K., & Hooper, L. V. (2011) · Science · doi:10.1126/science.1209791 · Cited by 1,412 · see citing works

Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial

Besselink, M. G., van Santvoort, H. C., Buskens, E., Boermeester, M. A., van Goor, H., Timmerman, H. M., Nieuwenhuijs, V. B., Bollen, T. L., van Ramshorst, B., Witteman, B. J., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60207-x · Cited by 1,367 · see citing works

Maintaining remission of ulcerative colitis with the probiotic <i>Escherichia coli</i> Nissle 1917 is as effective as with standard mesalazine

Kruis, W., Frič, P., Pokrotnieks, J., Lukáš, M., Fixa, B., Kaščák, M., Kamm, M. A., Weismueller, J., Beglinger, C., Stolte, M., et al. (2004) · Gut · doi:10.1136/gut.2003.037747 · Cited by 1,285 · see citing works

Faecalibacterium prausnitzii and human intestinal health

Miquel, S., Martín, R., Rossi, O., Bermúdez‐Humarán, L. G., Chatel, J., Sokol, H., Thomas, M., Wells, J. M., & Langella, P. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.003 · Cited by 1,239 · see citing works

Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

Heller, F., Florian, P., Bojarski, C., Richter, J. F., Christ, M., Hillenbrand, B., Mankertz, J., Gitter, A. H., Bürgel, N., Fromm, M., et al. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.002 · Cited by 1,237 · see citing works

Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans

Jumpertz, R., Le, D. S., Turnbaugh, P. J., Trinidad, C., Bogardus, C., Gordon, J. I., & Krakoff, J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.010132 · Cited by 1,232 · see citing works

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

Zeißig, S., Bürgel, N., Günzel, D., Richter, J. F., Mankertz, J., Wahnschaffe, U., Kroesen, A. J., Zeitz, M., Fromm, M., & Schulzke, J. (2006) · Gut · doi:10.1136/gut.2006.094375 · Cited by 1,218 · see citing works

Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects

Radilla-Vázquez, R. B., Parra‐Rojas, I., Martínez-Hernández, N. E., Márquez‐Sandoval, F., Illades‐Aguiar, B., & Castro-Alarcón, N. (2016) · Obesity Facts · doi:10.1159/000442479 · Cited by 1,200 · see citing works

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components1,2

Ulluwishewa, D., Anderson, R. C., McNabb, W. C., Moughan, P. J., Wells, J. M., & Roy, N. C. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.135657 · Cited by 1,177 · see citing works

Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial

Gionchetti, P., Rizzello, F., Helwig, U., Venturi, A., Lammers, K. M., Brigidi, P., Vitali, B., Poggioli, G., Miglioli, M., & Campieri, M. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00171-9 · Cited by 1,147 · see citing works

Moving pictures of the human microbiome

Caporaso, J. G., Lauber, C. L., Costello, E. K., Berg-Lyons, D., Gonzalez, A., Stombaugh, J., Knights, D., Gajer, P., Ravel, J., Fierer, N., et al. (2011) · Genome Biology · doi:10.1186/gb-2011-12-5-r50 · Cited by 1,138 · see citing works

A Primitive T Cell-Independent Mechanism of Intestinal Mucosal IgA Responses to Commensal Bacteria

Macpherson, A. J., Gatto, D., Sainsbury, E., Harriman, G. R., Hengartner, H., & Zinkernagel, R. M. (2000) · Science · doi:10.1126/science.288.5474.2222 · Cited by 1,113 · see citing works

Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial

Rembacken, B., Snelling, A. M., Hawkey, P. M., Chalmers, D. M., & Axon, A. (1999) · The Lancet · doi:10.1016/s0140-6736(98)06343-0 · Cited by 1,100 · see citing works

Probiotic bacteria enhance murine and human intestinal epithelial barrier function

Madsen, K., Cornish, A. S., Soper, P., McKaigney, C. J., Jijon, H. B., Yachimec, C., Doyle, J. S. G., Jewell, L. D., & Simone, C. D. (2001) · Gastroenterology · doi:10.1053/gast.2001.27224 · Cited by 1,096 · see citing works

The immune geography of IgA induction and function

Macpherson, A. J., McCoy, K. D., Johansen, F.-E., & Brandtzaeg, P. (2007) · Mucosal Immunology · doi:10.1038/mi.2007.6 · Cited by 1,047 · see citing works

Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens

Ng, K. M., Ferreyra, J. A., Higginbottom, S. K., Lynch, J. B., Kashyap, P. C., Gopinath, S., Naidu, N., Choudhury, B., Weimer, B. C., Monack, D. M., et al. (2013) · Nature · doi:10.1038/nature12503 · Cited by 1,035 · see citing works

Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

Heller, F., Florian, P., Bojarski, C., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.002 · Cited by 1,016 · see citing works

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Johansson, M. E. V., Gustafsson, J. K., Holmén-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjövall, H., et al. (2014) · Gut · doi:10.1136/gutjnl-2012-303207 · Cited by 1,004 · see citing works

The role of the gut microbiota in energy metabolism and metabolic disease

Cani, P., & Delzenne, N. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168164 · Cited by 974 · see citing works

Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications

Cusi, K. J. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.02.003 · Cited by 917 · see citing works

Intestinal barrier function in health and gastrointestinal disease

Camilleri, M., Madsen, K., Spiller, R., Van Meerveld, B. G., & Verne, G. N. (2012) · Neurogastroenterology &amp; Motility · doi:10.1111/j.1365-2982.2012.01921.x · Cited by 908 · see citing works

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

Eisenhoffer, G. T., Loftus, P. D., Yoshigi, M., Otsuna, H., Chien, C.-B., Morcos, P. A., & Rosenblatt, J. (2012) · Nature · doi:10.1038/nature10999 · Cited by 876 · see citing works

Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women

Santacruz, A., Collado, M. C., García-Valdés, L., Segura, M. T., Martín-Lagos, J. A., Anjos, T., Martí-Romero, M., Lopez, R. M., Florido, J., Campoy, C., et al. (2010) · British Journal of Nutrition · doi:10.1017/s0007114510000176 · Cited by 868 · see citing works

Diets with high or low protein content and glycemic index for weight-loss maintenance

Larsen, T. M., Dalskov, S.-M., van Baak, M., Jebb, S. A., Papadaki, A., Pfeiffer, A. F. H., Martinez, J. A., Handjieva-Darlenska, T., Kunešová, M., Pihlsgård, M., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1007137 · Cited by 843 · see citing works

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

Amar, J., Chabo, C., Waget, A., Klopp, P., Vachoux, C., Bermúdez‐Humarán, L. G., Smirnova, N. F., Bergé, M., Sulpice, T., Lahtinen, S. J., et al. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100159 · Cited by 837 · see citing works

Butyrate enhances intestinal epithelial barrier function via up-regulation of tight junction protein claudin-1 transcription

Wang, H.-B., Wang, P.-Y., Wang, X., Wan, Y.-L., & Liu, Y.-C. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2259-4 · Cited by 827 · see citing works

Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women

Dewulf, E. M., Cani, P. D., Claus, S. P., Fuentes, S., Puylaert, P. G., Neyrinck, A. M., Bindels, L. B., de Vos, W. M., Gibson, G. R., Thissen, J.-P., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303304 · Cited by 825 · see citing works

Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire

Weller, S. (2004) · Blood · doi:10.1182/blood-2004-01-0346 · Cited by 816 · see citing works

Targeting gut microbiota in obesity: effects of prebiotics and probiotics

Delzenne, N. M., Neyrinck, A. M., Bäckhed, F., & Cani, P. D. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.126 · Cited by 783 · see citing works

Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome

Barbara, G., Wang, B., Stanghellini, V., de Giorgio, R., Cremon, C., Di Nardo, G., Trevisani, M., Campi, B., Geppetti, P., Tonini, M., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.039 · Cited by 783 · see citing works

VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis

Bibiloni, R., Fedorak, R. N., Tannock, G. W., Madsen, K. L., Gionchetti, P., Campieri, M., Simone, C. D., & Sartor, R. B. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41794.x · Cited by 743 · see citing works

Disruption of the Epithelial Apical-Junctional Complex by Helicobacter pylori CagA

Amieva, M. R., Vogelmann, R., Covacci, A., Tompkins, L. S., Nelson, W. J., & Falkow, S. (2003) · Science · doi:10.1126/science.1081919 · Cited by 739 · see citing works

Whole Grain, Bran, and Germ Intake and Risk of Type 2 Diabetes: A Prospective Cohort Study and Systematic Review

de Munter, J. S. L., Hu, F. B., Spiegelman, D., Franz, M., & van Dam, R. M. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040261 · Cited by 734 · see citing works

The endocannabinoid system links gut microbiota to adipogenesis

Muccioli, G. G., Naslain, D., Bäckhed, F., Reigstad, C. S., Lambert, D. M., Delzenne, N. M., & Cani, P. D. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.46 · Cited by 691 · see citing works

Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier

Karczewski, J., Troost, F. J., Konings, I., Dekker, J., Kleerebezem, M., Brummer, R.-J. M., & Wells, J. M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00327.2009 · Cited by 676 · see citing works

Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection

Brandt, L. J., Aroniadis, O. C., Mellow, M., Kanatzar, A., Kelly, C., Park, T., Stollman, N., Rohlke, F., & Surawicz, C. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.60 · Cited by 672 · see citing works

Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier

Kong, J., Zhang, Z., Musch, M. W., Ning, G., Sun, J., Hart, J., Bissonnette, M., & Li, Y. C. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00398.2007 · Cited by 669 · see citing works

Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease

Fasano, A., Not, T., Wang, W., Uzzau, S., Berti, I., Tommasini, A., & Goldblum, S. E. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02169-3 · Cited by 668 · see citing works

Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia

Moreira, A. P. B., Teixeira, T. F. S., Machado, A. B. F., Pelúzio, M. D. C. G., & Alfenas, R. D. C. G. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001213 · Cited by 654 · see citing works

Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota

Sérino, M., Luche, É., Grès, S., Baylac, A., Bergé, M., Cénac, C., Waget, A., Klopp, P., Iacovoni, J. S., Klopp, C., et al. (2011) · Gut · doi:10.1136/gutjnl-2011-301012 · Cited by 621 · see citing works

Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice

Lam, Y. Y., Ha, C. W. Y., Campbell, C. R., Mitchell, A. J., Dinudom, A., Oscarsson, J., Cook, D. I., Hunt, N. H., Caterson, I. D., Holmes, A. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034233 · Cited by 604 · cited 2× · see citing works

Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation

Berkes, J., Viswanathan, V. K., Savkovic, S. D., & Hecht, G. (2003) · Gut · doi:10.1136/gut.52.3.439 · Cited by 594 · see citing works

Epithelial crosstalk at the microbiota–mucosal interface

Wells, J. M., Rossi, O., Meijerink, M., & van Baarlen, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000092107 · Cited by 574 · see citing works

Role of the Gut in Multiple Organ Failure: Bacterial Translocation and Permeability Changes

Swank, G. M., & Deitch, E. A. (1996) · World Journal of Surgery · doi:10.1007/s002689900065 · Cited by 565 · see citing works

Toll-Like Receptor 4 Is Involved in the Development of Fructose-Induced Hepatic Steatosis in Mice†

Spruss, A., Kanuri, G., Wagnerberger, S., Haub, S., Bischoff, S. C., & Bergheim, I. (2009) · Hepatology · doi:10.1002/hep.23122 · Cited by 563 · see citing works

A high-fat diet is associated with endotoxemia that originates from the gut

Pendyala, S., Walker, J. M., & Holt, P. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.01.034 · Cited by 546 · see citing works

Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

Piche, T., Barbara, G., Aubert, P., Bruley des Varannes, S., Dainese, R., Nano, J. L., Cremon, C., Stanghellini, V, De Giorgio, R., Galmiche, J. P., et al. (2009) · Gut · doi:10.1136/gut.2007.140806 · Cited by 540 · see citing works

Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: Role of endotoxin

Bergheim, I., Weber, S., Vos, M. B., Krämer, S., Volynets, V., Kaserouni, S., McClain, C. J., & Bischoff, S. C. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.01.035 · Cited by 523 · see citing works

Commensal Akkermansia muciniphila Exacerbates Gut Inflammation in Salmonella Typhimurium-Infected Gnotobiotic Mice

Ganesh, B. P., Klopfleisch, R., Loh, G., & Blaut, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074963 · Cited by 522 · see citing works

Effect of a Probiotic Preparation (VSL#3) on Induction and Maintenance of Remission in Children With Ulcerative Colitis

Miele, E., Pascarella, F., Giannetti, E., Quaglietta, L., Baldassano, R. N., & Staiano, A. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.118 · Cited by 517 · see citing works

Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation

Anderson, R. C., Cookson, A. L., McNabb, W. C., Park, Z., McCann, M. J., Kelly, W. J., & Roy, N. C. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-316 · Cited by 510 · see citing works

Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity

Saadat, I., Higashi, H., Obuse, C., Umeda, M., Murata‐Kamiya, N., Saito, Y., Lu, H., Ohnishi, N., Azuma, T., Suzuki, A., et al. (2007) · Nature · doi:10.1038/nature05765 · Cited by 501 · see citing works

Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans

Crenn, P., Coudray‐Lucas, C., Thuillier, F., Cynober, L., & Messing, B. (2000) · Gastroenterology · doi:10.1053/gast.2000.20227 · Cited by 495 · see citing works

Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis

Oláh, A., Belágyi, T., Issekutz, Á., Gamal, M., & Bengmark, S. (2002) · British Journal of Surgery · doi:10.1046/j.1365-2168.2002.02189.x · Cited by 493 · see citing works

Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients

Rayes, N., Seehofer, D., Hansen, S., Boucsein, K., Müller, A., Serke, S., Bengmark, S., & Neuhaus, P. (2002) · Transplantation · doi:10.1097/00007890-200207150-00021 · Cited by 488 · see citing works

Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity

Ukena, S. N., Singh, A., Dringenberg, U., Engelhardt, R., Seidler, U., Hansen, W., Bleich, A., Bruder, D., Franzke, A., Rogler, G., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001308 · Cited by 482 · see citing works

The microbiome and rheumatoid arthritis

Scher, J. U., & Abramson, S. B. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.121 · Cited by 479 · see citing works

Supply of Pre- and Probiotics Reduces Bacterial Infection Rates After Liver Transplantation—A Randomized, Double-Blind Trial

Rayes, N., Seehofer, D., Theruvath, T. P., Schiller, R. A., Langrehr, J. M., Jonas, S., Bengmark, S., & Neuhaus, P. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00649.x · Cited by 477 · see citing works

Pathobionts of the gastrointestinal microbiota and inflammatory disease

Chow, J., Tang, H., & Mazmanian, S. K. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.07.010 · Cited by 445 · see citing works

Microbial butyrate and its role for barrier function in the gastrointestinal tract

Plöger, S., Stumpff, F., Penner, G. B., Schulzke, J., Gäbel, G., Märtens, H., Shen, Z., Günzel, D., & Aschenbach, J. R. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06553.x · Cited by 445 · see citing works

The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases

Chassaing, B., & Darfeuille–Michaud, A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.054 · Cited by 443 · see citing works

Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut

Seki, E., & Schnabl, B. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.219691 · Cited by 440 · see citing works

Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake.

Thuy, S., Ladurner, R., Volynets, V., Wagner, S., Strahl, S., Königsrainer, A., Maier, K., Bischoff, S., & Bergheim, I. (2008) · Journal of NutriLife · doi:10.1093/jn/138.8.1452 · Cited by 432 · see citing works

Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKC? redistribution resulting in tight junction and epithelial barrier repair

Zyrek, A. A., Cichon, C., Helms, S., Enders, C., Sonnenborn, U., & Schmidt, M. A. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00836.x · Cited by 427 · see citing works

Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress

Zareie, M., Johnson‐Henry, K. C., Jury, J., Yang, P.-C., Ngan, B., McKay, D. M., Söderholm, J. D., Perdue, M. H., & Sherman, P. M. (2006) · Gut · doi:10.1136/gut.2005.080739 · Cited by 423 · see citing works

A guide to Ussing chamber studies of mouse intestine

Clarke, L. L. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90649.2008 · Cited by 419 · see citing works

T-Independent Immune Response: New Aspects of B Cell Biology

Fagarasan, S., & Honjo, T. (2000) · Science · doi:10.1126/science.290.5489.89 · Cited by 415 · see citing works

The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome

Klooker, T. K., Braak, B., Koopman, K. E., Welting, O., Wouters, M. M., der Heide, S. V., Schemann, M., Bischoff, S. C., van den Wijngaard, R. M., & Boeckxstaens, G. E. (2010) · Gut · doi:10.1136/gut.2010.213108 · Cited by 413 · see citing works

Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin

Wu, S., Lim, K.-C., Huang, J. H. Y., Saidi, R. F., & Sears, C. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14979 · Cited by 410 · see citing works

Dietary poorly absorbed, short‐chain carbohydrates increase delivery of water and fermentable substrates to the proximal colon

Barrett, J. S., Gearry, R. B., Muir, J. G., Irving, P. M., ROSE, R., Rosella, O., Haines, M. L., Shepherd, S., & Gibson, P. G. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04237.x · Cited by 403 · see citing works

Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome

Camilleri, M., Lasch, K. L., & Zhou, W. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00155.2012 · Cited by 397 · see citing works

Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut

Shroff, K. E., Meslin, K., & Cebra, J. J. (1995) · Infection and Immunity · doi:10.1128/iai.63.10.3904-3913.1995 · Cited by 397 · see citing works

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

Kießlich, R., Duckworth, C. A., Moussata, D., Gloeckner, A., Lim, L. G., Goetz, M., Pritchard, D. M., Galle, P. R., Neurath, M. F., & Watson, A. J. M. (2011) · Gut · doi:10.1136/gutjnl-2011-300695 · Cited by 394 · see citing works

Interplay between obesity and associated metabolic disorders: New insights into the gut microbiota

Cani, P. D., & Delzenne, N. M. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.06.016 · Cited by 377 · see citing works

Fecal transplantation, through colonoscopy, is effective therapy for recurrent Clostridium difficile infection

Mattila, E., Uusitalo–Seppälä, R., Wuorela, M., Lehtola, L., Nurmi, H., Ristikankare, M., Moilanen, V., Salminen, K., Seppälä, M., Mattila, P. S., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.11.037 · Cited by 371 · see citing works

Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model

Tsilingiri, K., Barbosa, T., Penna, G., Caprioli, F., Sonzogni, A., Viale, G., & Rescigno, M. (2012) · Gut · doi:10.1136/gutjnl-2011-300971 · Cited by 364 · see citing works

The Utility of Probiotics in the Treatment of Irritable Bowel Syndrome: A Systematic Review

Brenner, D. M., Moeller, M. J., Chey, W. D., & Schoenfeld, P. S. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.25 · Cited by 362 · see citing works

Exercise-Induced Splanchnic Hypoperfusion Results in Gut Dysfunction in Healthy Men

van Wijck, K., Lenaerts, K., van Loon, L. J. C., Peters, W. H. M., Buurman, W. A., & Dejong, C. H. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022366 · Cited by 359 · cited 1× · see citing works

Dysbiosis of Gut Microbiota [DOGMA]—A novel theory for the development of Polycystic Ovarian Syndrome

Tremellen, K., & Pearce, K. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.04.016 · Cited by 359 · see citing works

AMPylation of Rho GTPases by Vibrio VopS Disrupts Effector Binding and Downstream Signaling

Yarbrough, M. L., Li, Y., Kinch, L. N., et al. (2008) · Science · doi:10.1126/science.1166382 · Cited by 355 · see citing works

Activation of Human Enteric Neurons by Supernatants of Colonic Biopsy Specimens From Patients With Irritable Bowel Syndrome

Buhner, S., Li, Q., Vignali, S., Barbara, G., De Giorgio, R., Stanghellini, V., Cremon, C., Zeller, F., Langer, R., Daniel, H., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.005 · Cited by 351 · see citing works

Early increase in intestinal permeability in patients with severe acute pancreatitis: Correlation with endotoxemia, organ failure, and mortality

Ammori, B., Leeder, P., King, R., Barclay, G., Martin, I., Larvin, M., & Mcmahon, M. (1999) · Journal of Gastrointestinal Surgery · doi:10.1016/s1091-255x(99)80067-5 · Cited by 346 · see citing works

Dietary Fiber Intake and Mortality in the NIH-AARP Diet and Health Study

Park, Y., Subar, A. F., Hollenbeck, A. R., & Schatzkin, A. G. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.18 · Cited by 344 · see citing works

Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function

Patel, R. M., Myers, L. S., Kurundkar, A. R., Maheshwari, A., Nusrat, A., & Lin, P. W. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.10.025 · Cited by 341 · see citing works

Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate†

Lewis, K. J., Lutgendorff, F., Phan, V., Söderholm, J. D., Sherman, P. M., & McKay, D. M. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21177 · Cited by 338 · see citing works

'Gut health': a new objective in medicine?

Bischoff, S. C. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-24 · Cited by 338 · see citing works

Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept

for the D.E.S.I.R. Study Group, Amar, J., Sérino, M., Lange, C., Chabo, C., Iacovoni, J. S., Mondot, S., Lepage, P., Klopp, C., Mariette, J., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2329-8 · Cited by 327 · see citing works

Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis

Rosenfeldt, V., Benfeldt, E., Valerius, N. H., Pærregaard, A., & Michaelsen, K. F. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.06.068 · Cited by 326 · see citing works

Tight Junction–associated MARVEL Proteins MarvelD3, Tricellulin, and Occludin Have Distinct but Overlapping Functions

Raleigh, D. R., Marchiando, A. M., Zhang, Y., Shen, L., Sasaki, H., Wang, Y., Long, M., & Turner, J. R. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-08-0734 · Cited by 326 · see citing works

PASSCLAIM1?Gut health and immunity

Cummings, J. H., Antoine, J.-M., Azpiroz, F., Bourdet-Sicard, R., Brandtzaeg, P., Calder, P. C., Gibson, G. R., Guarner, F., Isolauri, E., Pannemans, D., et al. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-1205-4 · Cited by 324 · see citing works

Vitamin D Deficiency in Patients With Inflammatory Bowel Disease

Ulitsky, A., Ananthakrishnan, A. N., Naik, A. S., et al. (2011) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607110381267 · Cited by 319 · see citing works

Is small intestinal permeability really increased in relatives of patients with Crohn's disease?

May, G. R., Sutherland, L. R., & Meddings, J. B. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90638-s · Cited by 316 · see citing works

Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications

Mankertz, J., & Schulzke, J.-D. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32816aa392 · Cited by 312 · see citing works

Probiotics and Commensals Reverse TNF-α– and IFN-γ–Induced Dysfunction in Human Intestinal Epithelial Cells

Resta‐Lenert, S. C., & Barrett, K. E. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.12.015 · Cited by 308 · see citing works

The intestinal microbiota and chronic disorders of the gut

Dupont, A. W., & DuPont, H. L. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.133 · Cited by 306 · see citing works

A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome

Hoveyda, N., Heneghan, C., Mahtani, K. R., Perera, R., Roberts, N., & Glasziou, P. (2009) · BMC Gastroenterology · doi:10.1186/1471-230x-9-15 · Cited by 297 · see citing works

Heterogeneous metabolic adaptation of C57BL/6J mice to high-fat diet

Burcelin, R., Crivelli, V., Dacosta, A., Roy-Tirelli, A., & Thorens, B. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00332.2001 · Cited by 292 · see citing works

Physiology and pathophysiology of splanchnic hypoperfusion and intestinal injury during exercise: strategies for evaluation and prevention

van Wijck, K., Lenaerts, K., Grootjans, J., Wijnands, K. A. P., Poeze, M., van Loon, L. J. C., Dejong, C. H. C., & Buurman, W. A. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00066.2012 · Cited by 285 · see citing works

Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier

Martínez, C., Lobo, B., Pigrau, M., Ramos, L., González-Castro, A. M., Alonso, C., Guilarte, M., Guilá, M., de Torres, I., Azpiroz, F., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-302093 · Cited by 283 · see citing works

Randomised clinical trial: the effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitis

Oliva, S., Nardo, G. D., Ferrari, F., Mallardo, S., Rossi, P., Patrizi, G., Cucchiara, S., & Stronati, L. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04939.x · Cited by 280 · see citing works

The gastrointestinal tract stem cell niche

Yen, T., & Wright, N. A. (2006) · Stem Cell Reviews and Reports · doi:10.1007/s12015-006-0048-1 · Cited by 279 · see citing works

Examining the Role of Paneth Cells in the Small Intestine by Lineage Ablation in Transgenic Mice

Garabedian, E. M., Roberts, L. J., McNevin, M. S., & Gordon, J. I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23729 · Cited by 279 · see citing works

Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics

Hering, N. A., Fromm, M., & Schulzke, J. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.224568 · Cited by 279 · see citing works

The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding

Marchiando, A. M., Shen, L., Graham, W. V., Edelblum, K. L., Duckworth, C. A., Guan, Y., Montrose, M. H., Turner, J. R., & Watson, A. J. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.004 · Cited by 276 · see citing works

IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms

Macpherson, A. J., Hunziker, L., McCoy, K. D., & Lamarre, A. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(01)01460-5 · Cited by 275 · see citing works

Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells

Bagnoli, F., Buti, L., Tompkins, L. S., Covacci, A., & Amieva, M. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502598102 · Cited by 267 · see citing works

Identification of a Bacterial Type III Effector Family with G Protein Mimicry Functions

Alto, N. M., Shao, F., Lazar, C. S., Brost, R. L., Chua, G., Mattoo, S., McMahon, S. A., Ghosh, P., Hughes, T. R., Boone, C. M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.10.031 · Cited by 262 · see citing works

Relation of C-Reactive Protein to Abdominal Adiposity

Brooks, G. C., Blaha, M. J., & Blumenthal, R. S. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.02.017 · Cited by 255 · see citing works

Immune dysfunction in inflammatory bowel disease

Neuman, M. G. (2007) · Translational research · doi:10.1016/j.trsl.2006.11.009 · Cited by 253 · see citing works

A Randomized Controlled Trial of <i>Lactobacillus</i> GG in Children With Functional Abdominal Pain

Francavilla, R., Miniello, V., Magistà, A. M., De Canio, A., Bucci, N., Gagliardi, F., Lionetti, E., Castellaneta, S., Polimeno, L., Peccarisi, L., et al. (2010) · Pediatrics · doi:10.1542/peds.2010-0467 · Cited by 242 · see citing works

Proteomic Analyses of the Two Mucus Layers of the Colon Barrier Reveal That Their Main Component, the Muc2 Mucin, Is Strongly Bound to the Fcgbp Protein

Johansson, M., Thomsson, K. A., & Hansson, G. C. (2009) · Journal of Proteome Research · doi:10.1021/pr9002504 · Cited by 237 · see citing works

Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury

Wang, Y., Liu, Y., Sidhu, A., Ma, Z., McClain, C. J., & Feng, W. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00024.2012 · Cited by 235 · see citing works

Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome

Delzenne, N. M., Neyrinck, A. M., & Cani, P. D. (2011) · Microbial Cell Factories · doi:10.1186/1475-2859-10-s1-s10 · Cited by 231 · see citing works

Effect of Enteral Nutrition and Synbiotics on Bacterial Infection Rates After Pylorus-preserving Pancreatoduodenectomy

Rayes, N., Seehofer, D., Theruvath, T. P., Mogl, M. T., Langrehr, J. M., Nüssler, N. C., Bengmark, S., & Neuhaus, P. (2007) · Annals of Surgery · doi:10.1097/01.sla.0000259442.78947.19 · Cited by 228 · see citing works

Health benefits and health claims of probiotics: bridging science and marketing

Rijkers, G. T., de Vos, W. M., Brummer, R. J., Morelli, L., Corthier, G., & Marteau, P. R. (2011) · British Journal Of Nutrition · doi:10.1017/s000711451100287x · Cited by 226 · see citing works

Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non‐alcoholic steatohepatitis

Farhadi, A., Gundlapalli, S., Shaikh, M. W., Frantzides, C. T., Harrell, L. E., Kwasny, M., & Keshavarzian, A. (2008) · Liver International · doi:10.1111/j.1478-3231.2008.01723.x · Cited by 225 · see citing works

Physiological and pathophysiological functions of intestinal mast cells

Bischoff, S. C. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0165-4 · Cited by 225 · see citing works

Synbiotic control of inflammation and infection in severe acute pancreatitis: a prospective, randomized, double blind study.

Oláh, A., Belágyi, T., Pótó, L., Romics, L., & Bengmark, S. (2007) · PubMed · Cited by 223 · see citing works

Intestinal Serotonin Release, Sensory Neuron Activation, and Abdominal Pain in Irritable Bowel Syndrome

Cremon, C., Carini, G., Wang, B., Vasina, V., Cogliandro, R. F., De Giorgio, R., Stanghellini, V., Grundy, D., Tonini, M., De Ponti, F., et al. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.86 · Cited by 223 · see citing works

Non-Invasive Markers for Early Diagnosis and Determination of the Severity of Necrotizing Enterocolitis

Thuijls, G., Derikx, J. P. M., van Wijck, K., Zimmermann, L. J. I., Degraeuwe, P. L. J., Mulder, A., van der Zee, D. C., BROUWERS, H. A. A., Verhoeven, B. H., van Heurn, E. L. W., et al. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181d778c4 · Cited by 222 · see citing works

Identification of Epithelial Gaps in Human Small and Large Intestine by Confocal Endomicroscopy

Kießlich, R., Goetz, M., Angus, E. M., Hu, Q., Guan, Y., Potten, C., Allen, T., Neurath, M. F., Shroyer, N. F., Montrose, M. H., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.09.011 · Cited by 217 · see citing works

Early Diagnosis of Intestinal Ischemia Using Urinary and Plasma Fatty Acid Binding Proteins

Thuijls, G., Wijck, K. V., Grootjans, J., Derikx, J. P. M., van Bijnen, A. A., Heineman, E., Dejong, C. H. C., Buurman, W. A., & Poeze, M. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e318207a767 · Cited by 217 · see citing works

Review article: probiotics for the treatment of irritable bowel syndrome – focus on lactic acid bacteria

Clarke, G. A., Cryan, J. F., Dinan, T. G., & Quigley, E. M. M. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04965.x · Cited by 217 · see citing works

The immune system in irritable bowel syndrome

Barbara, G., Cremon, C., Carini, G., Bellacosa, L., Zecchi, L., Giorgio, R. D., Corinaldesi, R., & Stanghellini, V. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.4.349 · Cited by 211 · see citing works

Salmonella enterica serovar Typhimurium effectors SopB, SopE, SopE2 and SipA disrupt tight junction structure and function

Boyle, E. C., Brown, N. F., & Finlay, B. B. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00762.x · Cited by 208 · see citing works

The effect of a bifidobacter supplemented bovine milk on intestinal permeability of preterm infants

Stratiki, Z., Costalos, C., Sevastiadou, S., Kastanidou, O., Skouroliakou, M., Giakoumatou, A., & Petrohilou, V. (2007) · Early Human Development · doi:10.1016/j.earlhumdev.2006.12.002 · Cited by 208 · see citing works

The Role of Diet in Symptoms of Irritable Bowel Syndrome in Adults: A Narrative Review

Heizer, W. D., Southern, S., & McGovern, S. (2009) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2009.04.012 · Cited by 207 · see citing works

Role of serotonin in intestinal inflammation: Knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice

Bischoff, S. C., Mailer, R., Pabst, O., Weier, G., Sedlik, W., Li, Z., Chen, J. J., Murphy, D. L., & Gershon, M. D. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90685.2008 · Cited by 206 · see citing works

Non-invasive assessment of barrier integrity and function of the human gut

Grootjans, J. (2010) · World Journal of Gastrointestinal Surgery · doi:10.4240/wjgs.v2.i3.61 · Cited by 203 · see citing works

The Gut Barrier

Scaldaferri, F., Pizzoferrato, M., Gerardi, V., Lopetuso, L. R., & Gasbarrini, A. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31826ae849 · Cited by 203 · see citing works

Lysate of Probiotic Lactobacillus casei DN-114 001 Ameliorates Colitis by Strengthening the Gut Barrier Function and Changing the Gut Microenvironment

Zakostelska, Z. J., Kverka, M., Kostovcikova, K., Rossmann, P., Mrázek, J., Kopečný, J., Hornová, M., Šrůtková, D., Hudcovic, T., Rídl, J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027961 · Cited by 201 · see citing works

Serum I‐ FABP as marker for enterocyte damage in coeliac disease and its relation to villous atrophy and circulating autoantibodies

Adriaanse, M. P. M., Tack, G. J., Passos, V. L., Damoiseaux, J. G. M. C., Schreurs, M. W. J., van Wijck, K., Riedl, R. G., Masclee, A., Buurman, W. A., Mulder, C. J. J., et al. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12194 · Cited by 200 · see citing works

Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1

Wu, Z., Nybom, P., & Magnusson, K.-E. (2000) · Cellular Microbiology · doi:10.1046/j.1462-5822.2000.00025.x · Cited by 195 · see citing works

Lactobacillus plantarum DSM 2648 is a potential probiotic that enhances intestinal barrier function

Anderson, R. C., Cookson, A. L., McNabb, W. C., Kelly, W. J., & Roy, N. C. (2010) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2010.02038.x · Cited by 194 · see citing works

Helicobacter pylori Dysregulation of Gastric Epithelial Tight Junctions by Urease-Mediated Myosin II Activation

Wroblewski, L. E., Shen, L., Ogden, S., Romero–Gallo, J., Lapierre, L. A., Israel, D. A., Turner, J. R., & Peek, R. M. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.10.011 · Cited by 193 · see citing works

Clinical trial: effect of active lactic acid bacteria on mucosal barrier function in patients with diarrhoea-predominant irritable bowel syndrome

ZENG, J., LI, Y. ‐., ZUO, X. ‐., ZHEN, Y. ‐., YANG, J., & LIU, C. ‐. (2008) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/j.1365-2036.2008.03818.x · Cited by 189 · see citing works

Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway

Gu, Y., Forostyan, T. V., Sabbadini, R. A., & Rosenblatt, J. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201010075 · Cited by 187 · see citing works

Loss of Claudins 2 and 15 From Mice Causes Defects in Paracellular Na+ Flow and Nutrient Transport in Gut and Leads to Death from Malnutrition

Wada, M., Tamura, A., Takahashi, N., & Tsukita, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.10.035 · Cited by 185 · see citing works

Increased Proteasome-Mediated Degradation of Occludin in Irritable Bowel Syndrome

Coëffier, M., Gloro, R., Boukhettala, N., Aziz, M., Lecleire, S., Vandaele, N., Antonietti, M., Savoye, G., Bôle-Feysot, C., Déchelotte, P., et al. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.700 · Cited by 185 · see citing works

Influence ofSaccharomyces boulardiion the intestinal permeability of patients with Crohn's disease in remission

Vilela, E. G., Ferrari, M. D. L. A., Tôrres, H. O. D. G., Pinto, A. G., Aguirre, A. C. C., Martins, F. P., Goulart, E. M. A., & da Cunha, A. S. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520801943354 · Cited by 183 · see citing works

Sucrose: A novel permeability marker for gastroduodenal disease

Meddings, J. B., Sutherland, L. R., Byles, N. I. A., & Wallace, J. L. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90637-r · Cited by 179 · see citing works

L. plantarum prevents Enteroinvasive Escherichia coli-induced tight junction proteins changes in intestinal epithelial cells

Qin, H., Zhang, Z., Hang, X., & Jiang, Y. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-63 · Cited by 175 · see citing works

Protein Kinase C Signaling Regulates ZO-1 Translocation and Increased Paracellular Flux of T84 Colonocytes Exposed toClostridium difficile Toxin A

Chen, M. L., Pothoulakis, C., & LaMont, J. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109254200 · Cited by 172 · see citing works

Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function

Spruss, A., Kanuri, G., Stahl, C., Bischoff, S. C., & Bergheim, I. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.75 · Cited by 168 · see citing works

Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease

Spruss, A., & Bergheim, I. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.05.006 · Cited by 162 · see citing works

Intestinal permeability in coeliac disease: insight into mechanisms and relevance to pathogenesis

Heyman, M., Abed, J., Lebreton, C., & Cerf–Bensussan, N. (2011) · Gut · doi:10.1136/gutjnl-2011-300327 · Cited by 162 · see citing works

Influence of apple polyphenols on inflammatory gene expression

Jung, M., Triebel, S., Anke, T., Richling, E., & Erkel, G. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800575 · Cited by 161 · see citing works

Polyphenol Supplementation as a Complementary Medicinal Approach to Treating Inflammatory Bowel Disease

Biasi, F., Astegiano, M., Maina, M., Leonarduzzi, G., & Poli, G. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711797535263 · Cited by 152 · see citing works

Monitoring myeloablative therapy‐induced small bowel toxicity by serum citrulline concentration

Lutgens, L. C. H. W., Blijlevens, N. M. A., Deutz, N. E. P., Donnelly, J. P., Lambin, P., & Pauw, B. E. D. (2004) · Cancer · doi:10.1002/cncr.20733 · Cited by 150 · see citing works

Calprotectin, a faecal marker of organic gastrointestinal abnormality

Fagerhol, M. K. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03224-4 · Cited by 149 · see citing works

Acute Alcohol-Induced Liver Injury

Massey, V. L., & Arteel, G. E. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00193 · Cited by 147 · see citing works

Lactobacillus casei DN-114 001 inhibits the increase in paracellular permeability of enteropathogenic Escherichia coli-infected T84 cells

Parassol, N., Freitas, M., Thoreux, K., Dalmasso, G., Bourdet‐Sicard, R., & Rampal, P. (2004) · Research in Microbiology · doi:10.1016/j.resmic.2004.09.013 · Cited by 146 · see citing works

Lactobacillus casei downregulates commensalsʼ inflammatory signals in Crohnʼs disease mucosa

Llopis, M., Antolı́n, M., Carol, M., Borruel, N., Casellas, F., Martínez, C., Espín, E., Guarner, F., & Malagelada, J. R. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20736 · Cited by 145 · see citing works

Intestinal permeability in patients with adverse reactions to food

Ventura, M. T., Polimeno, L., Amoruso, A., Gatti, F. L., Annoscia, E., Marinaro, M., Leo, E. D., Matino, M., Buquicchio, R., Bonini, S., et al. (2006) · Digestive and Liver Disease · doi:10.1016/j.dld.2006.06.012 · Cited by 144 · see citing works

Innate immune dysfunction in inflammatory bowel disease

Gersemann, M., Wehkamp, J., & Stange, E. F. (2012) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02515.x · Cited by 143 · see citing works

Combination of Allergic Factors Can Worsen Diarrheic Irritable Bowel Syndrome: Role of Barrier Defects and Mast Cells

Vivinus-Nébot, M., Dainese, R., Anty, R., Saint‐Paul, M., Nano, J. L., Gonthier, N., Marjoux, S., Frin-Mathy, G., Bernard, G., Hébuterne, X., et al. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.315 · Cited by 141 · see citing works

Cannabinoids mediate opposing effects on inflammation‐induced intestinal permeability

Alhamoruni, A., Wright, K. L., Larvin, M., & O’Sullivan, S. E. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01589.x · Cited by 138 · see citing works

Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease

Wehkamp, J., Koslowski, M. J., Wang, G., & Stange, E. F. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.48 · Cited by 136 · see citing works

Interactions Among Secretory Immunoglobulin A, CD71, and Transglutaminase-2 Affect Permeability of Intestinal Epithelial Cells to Gliadin Peptides

Lebreton, C., Ménard, S., Abed, J., Moura, I. C., Coppo, R., Dugave, C., Monteiro, R. C., Fricot, A., Garfa‐Traoré, M., Griffin, M., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.05.051 · Cited by 134 · see citing works

Level of Activation of the Unfolded Protein Response Correlates With Paneth Cell Apoptosis in Human Small Intestine Exposed to Ischemia/Reperfusion

Grootjans, J., Hodin, C. M. I. M., de Haan, J. J., Derikx, J. P. M., Rouschop, K. M. A., Verheyen, F., van Dam, R. M., Dejong, C. H. C., Buurman, W. A., & Lenaerts, K. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.10.040 · Cited by 132 · see citing works

Paneth cell defensins and the regulation of the microbiome

Salzman, N. H. (2010) · Gut Microbes · doi:10.4161/gmic.1.6.14076 · Cited by 128 · see citing works

Novel multi-sugar assay for site-specific gastrointestinal permeability analysis: A randomized controlled crossover trial

van Wijck, K., Verlinden, T. J. M., van Eijk, H. M. H., Dekker, J. P., Buurman, W. A., Dejong, C. H. C., & Lenaerts, K. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.06.014 · Cited by 125 · see citing works

Lactobacillus casei Shirota protects from fructose-induced liver steatosis: A mouse model

Wagnerberger, S., Spruss, A., Kanuri, G., Stahl, C., Schröder, M., Vetter, W., Bischoff, S. C., & Bergheim, I. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.01.014 · Cited by 123 · see citing works

The effect of intestinal hypoperfusion on intestinal absorption and permeability during cardiopulmonary bypass

Ohri, S. K., Somasundaram, S. G., Koak, Y., Macpherson, A. J., Keogh, B. E., Taylor, K. M., Menzies, I. S., & Bjarnason, I. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90588-6 · Cited by 121 · see citing works

The gut as communicator between environment and host: Immunological consequences

Brandtzæg, P. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.07.006 · Cited by 121 · see citing works

Probiotics and prebiotics in the management of irritable bowel syndrome: a review of recent clinical trials and systematic reviews

Whelan, K. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32834b8082 · Cited by 120 · see citing works

Gastrointestinal permeability in celiac disease

Smecuol, E., Bai, J., Vázquez, H., Kogan, Z., Cabanne, A., Niveloni, S. I., Pedreira, S. C., Boerr, L., Mauriño, E. C., & Meddings, J. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70123-9 · Cited by 120 · see citing works

Probiotic bacteria regulate intestinal epithelial permeability in experimental ileitis by a TNF-dependent mechanism

Corridoni, D., Pastorelli, L., Mattioli, B., Locovei, S., Ishikawa, D., Arseneau, K. O., Chieppa, M., Cominelli, F., & Pizarro, T. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042067 · Cited by 118 · see citing works

Intestinal permeability in the critically ill

Harris, C., Griffiths, R. D., Freestone, N. S., Billington, D., Atherton, S., & Macmillan, R. R. (1992) · Intensive Care Medicine · doi:10.1007/bf01706424 · Cited by 116 · see citing works

Gastrointestinal permeability in celiac disease

Oberhuber, G., & Vogelsang, H. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70661-4 · Cited by 114 · see citing works

Ischaemia-induced mucus barrier loss and bacterial penetration are rapidly counteracted by increased goblet cell secretory activity in human and rat colon

Grootjans, J., Hundscheid, I. H. R., Lenaerts, K., Boonen, B., Renes, I. B., Verheyen, F., Dejong, C. H. C., MEYENFELDT, M. F. V., Beets, G. L., & Buurman, W. A. (2012) · Gut · doi:10.1136/gutjnl-2011-301956 · Cited by 109 · see citing works

Effects of Glutamine Supplements and Radiochemotherapy on Systemic Immune and Gut Barrier Function in Patients With Advanced Esophageal Cancer

Yoshida, S., Matsui, M., Shirouzu, Y., Fujita, H., Yamana, H., & Shirouzu, K. (1998) · Annals of Surgery · doi:10.1097/00000658-199804000-00006 · Cited by 107 · see citing works

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110 · see citing works

The intestinal microbiota fuelling metabolic inflammation

Tilg, H., Zmora, N., Adolph, T. E., & Elinav, E. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0198-4 · Cited by 1,089 · see citing works

Leaky gut: mechanisms, measurement and clinical implications in humans

Camilleri, M. (2019) · Gut · doi:10.1136/gutjnl-2019-318427 · Cited by 1,081 · see citing works

The gut microbiota in anxiety and depression—A systematic review

Simpson, C. A., Diaz-Arteche, C., Eliby, D., Schwartz, O. S., Simmons, J. G., & Cowan, C. S. M. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101943 · Cited by 912 · see citing works

Microbiota-Brain-Gut Axis and Neurodegenerative Diseases

Quigley, E. M. M. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0802-6 · Cited by 804 · see citing works

Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut

Michielan, A., & D’Incà, R. (2015) · Mediators of Inflammation · doi:10.1155/2015/628157 · Cited by 709 · see citing works

Gut Microbiota’s Effect on Mental Health: The Gut-Brain Axis

Clapp, M., Aurora, N., Herrera, L., Bhatia, M., Wilen, E., & Wakefield, S. (2017) · Clinics and Practice · doi:10.4081/cp.2017.987 · Cited by 608 · see citing works

The endotoxin hypothesis of neurodegeneration

Brown, G. C. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1564-7 · Cited by 457 · see citing works

Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics

Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., Barrea, L., Hassan, S. T. S., Šmejkal, K., Malaník, M., et al. (2019) · Theranostics · doi:10.7150/thno.30787 · Cited by 465 · see citing works

Age-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk

Chia, C. W., Egan, J. M., & Ferrucci, L. (2018) · Circulation Research · doi:10.1161/circresaha.118.312806 · Cited by 454 · see citing works

Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress

Karl, J. P., Margolis, L. M., Madslien, E. H., Murphy, N. E., Castellani, J. W., Gundersen, Y., Hoke, A. V., Levangie, M. W., Kumar, R., Chakraborty, N., et al. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00066.2017 · Cited by 373 · see citing works

Ultra-processed Foods and Cardiovascular Diseases: Potential Mechanisms of Action

Juul, F., Vaidean, G., & Parekh, N. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab049 · Cited by 374 · see citing works

The Intestinal Microenvironment and Functional Gastrointestinal Disorders

Barbara, G., Feinle-Bisset, C., Ghoshal, U. C., Santos, J., Vanner, S. J., Vergnolle, N., Zoetendal, E. G., & Quigley, E. M. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.028 · Cited by 335 · see citing works

Gut reactions: Breaking down xenobiotic–microbiome interactions

Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319 · see citing works

Primary biliary cholangitis: pathogenesis and therapeutic opportunities

Gulamhusein, A. F., & Hirschfield, G. M. (2020) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-019-0226-7 · Cited by 308 · see citing works

Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

Pellegrini, C., Antonioli, L., Colucci, R., Blandizzi, C., & Fornai, M. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1856-5 · Cited by 270 · see citing works

Intersections Between Microbiome and Heart Failure: Revisiting the Gut Hypothesis

Nagatomo, Y., & Tang, W. H. W. (2015) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2015.09.017 · Cited by 259 · see citing works

Microbes, immunity, and behavior: psychoneuroimmunology meets the microbiome

Dinan, T. G., & Cryan, J. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.103 · Cited by 246 · see citing works

Irritable bowel syndrome, the microbiota and the gut-brain axis

Raskov, H., Burcharth, J., Pommergaard, H.-C., & Rosenberg, J. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1218585 · Cited by 243 · see citing works

The intestinal barrier in disorders of the central nervous system

Pellegrini, C., Fornai, M., D'Antongiovanni, V., Antonioli, L., Bernardini, N., & Derkinderen, P. (2023) · The Lancet Gastroenterology &amp; Hepatology · doi:10.1016/s2468-1253(22)00241-2 · Cited by 239 · see citing works

Nutritional Keys for Intestinal Barrier Modulation

De Santis, S., Cavalcanti, E., Mastronardi, M., Jirillo, E., & Chieppa, M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00612 · Cited by 232 · see citing works

Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization

Andriessen, E. M., Wilson, A. M., Mawambo, G., Dejda, A., Miloudi, K., Sennlaub, F., & Sapieha, P. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606531 · Cited by 201 · see citing works

Endoscopic duodenal mucosal resurfacing for the treatment of type 2 diabetes mellitus: one year results from the first international, open-label, prospective, multicentre study

van Baar, A. C. G., Holleman, F., Crenier, L., Haidry, R., Magee, C., Hopkins, D., Rodriguez Grunert, L., Galvao Neto, M., Vignolo, P., Hayee, B., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-318349 · Cited by 201 · see citing works

Gut permeability is related to body weight, fatty liver disease, and insulin resistance in obese individuals undergoing weight reduction

Damms-Machado, A., Louis, S., Schnitzer, A., Volynets, V., Rings, A., Basrai, M., & Bischoff, S. C. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.131110 · Cited by 195 · see citing works

Intestinal Barrier Dysfunction in Irritable Bowel Syndrome: A Systematic Review

Hanning, N., Edwinson, A. L., Ceuleers, H., Peters, S. A., De Man, J. G., Hassett, L. C., De Winter, B. Y., & Grover, M. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284821993586 · Cited by 197 · see citing works

Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes

Massier, L., Chakaroun, R., Tabei, S., Crane, A., Didt, K. D., Fallmann, J., von Bergen, M., Haange, S.-B., Heyne, H., Stumvoll, M., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-320118 · Cited by 194 · see citing works

Population-level Metagenomics Uncovers Distinct Effects of Multiple Medications on the Human Gut Microbiome

Nagata, N., Nishijima, S., Miyoshi-Akiyama, T., Kojima, Y., Kimura, M., Aoki, R., Ohsugi, M., Ueki, K., Miki, K., Iwata, E., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.070 · Cited by 178 · see citing works

Alcohol or gut microbiota: who is the guilty?

Meroni, M., Longo, M., & Dongiovanni, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184568 · Cited by 183 · see citing works

Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications?

Pellegrini, C., Antonioli, L., Calderone, V., Colucci, R., Fornai, M., & Blandizzi, C. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101806 · Cited by 174 · see citing works

Short-chain fatty acids are key mediators of the favorable effects of the Mediterranean diet on intestinal barrier integrity: data from the randomized controlled LIBRE trial

Seethaler, B., Nguyen, N. K., Basrai, M., Kiechle, M., Walter, J., Delzenne, N. M., & Bischoff, S. C. (2022) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac175 · Cited by 179 · see citing works

The gut Microbiome in adult and pediatric functional gastrointestinal disorders

Shin, A., Preidis, G. A., Shulman, R., & Kashyap, P. C. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.054 · Cited by 163 · see citing works

Crosstalk between the gut microbiome and colonic motility in chronic constipation: potential mechanisms and microbiota modulation

Pan, R., Wang, L., Xu, X., Chen, Y., Wang, H., Wang, G., Zhao, J., & Chen, W. (2022) · Nutrients · doi:10.3390/nu14183704 · Cited by 149 · see citing works

Exposure to traffic-related air pollution and the composition of the gut microbiota in overweight and obese adolescents

Alderete, T. L., Jones, R. B., Chen, Z., Kim, J. S., Habre, R., Lurmann, F., Gilliland, F. D., & Goran, M. I. (2018) · Environmental Research · doi:10.1016/j.envres.2017.11.046 · Cited by 139 · see citing works

Food Design To Feed the Human Gut Microbiota

Ercolini, D., & Fogliano, V. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b00456 · Cited by 146 · see citing works

Role of brain imaging in disorders of brain–gut interaction: a Rome Working Team Report

Mayer, E. A., Labus, J., Aziz, Q., Tracey, I., Kilpatrick, L., Elsenbruch, S., Schweinhardt, P., Van Oudenhove, L., & Borsook, D. (2019) · Gut · doi:10.1136/gutjnl-2019-318308 · Cited by 138 · see citing works

The Link between Gut Dysbiosis and Neuroinflammation in Parkinson’s Disease

Baizabal-Carvallo, J. F., & Alonso-Juarez, M. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.02.030 · Cited by 130 · see citing works

A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: The MaPLE randomised controlled trial

Del Bo', C., Bernardi, S., Cherubini, A., Porrini, M., Gargari, G., Hidalgo-Liberona, N., González-Domínguez, R., Zamora-Ros, R., Peron, G., Marino, M., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.014 · Cited by 133 · see citing works

The gut microbiome in psoriasis and psoriatic arthritis

Myers, B., Brownstone, N., Reddy, V., Chan, S., Thibodeaux, Q., Truong, A., Bhutani, T., Chang, H.-W., & Liao, W. (2019) · Best Practice &amp; Research Clinical Rheumatology · doi:10.1016/j.berh.2020.101494 · Cited by 127 · see citing works

Potential Benefits of Dietary Fibre Intervention in Inflammatory Bowel Disease

Wong, C., Harris, P., & Ferguson, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060919 · Cited by 116 · see citing works

Microbiota-gut-brain axis: enteroendocrine cells and the enteric nervous system form an interface between the microbiota and the central nervous system

KUWAHARA, A., MATSUDA, K., KUWAHARA, Y., ASANO, S., INUI, T., & MARUNAKA, Y. (2020) · Biomedical Research · doi:10.2220/biomedres.41.199 · Cited by 112 · see citing works

The Intestinal Barrier in Parkinson’s Disease: Current State of Knowledge

van IJzendoorn, S. C. D., & Derkinderen, P. (2019) · Journal of Parkinson’s Disease · doi:10.3233/jpd-191707 · Cited by 97 · see citing works

Effects of Prebiotic and Probiotic Supplementation on Lactase Deficiency and Lactose Intolerance: A Systematic Review of Controlled Trials

Leis, R., de Castro, M.-J., de Lamas, C., Picáns, R., & Couce, M. L. (2020) · Nutrients · doi:10.3390/nu12051487 · Cited by 101 · see citing works

The Transplantation of ω3 PUFA–Altered Gut Microbiota of fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders

Bidu, C., Escoula, Q., Bellenger, S., Spor, A., Galan, M., Geissler, A., Bouchot, A., Dardevet, D., Morio, B., Cani, P. D., et al. (2018) · Diabetes · doi:10.2337/db17-1488 · Cited by 90 · see citing works

The effects of a multispecies probiotic on migraine and markers of intestinal permeability – results of a randomized placebo-controlled study

de Roos, N. M., van Hemert, S., Rovers, J. M. P., Smits, M. G., & Witteman, B. J. M. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2017.57 · Cited by 89 · see citing works

Keeping <i>Candida</i> commensal: how lactobacilli antagonize pathogenicity of <i>Candida albicans</i> in an <i>in vitro</i> gut model

Graf, K., Last, A., Gratz, R., Allert, S., Linde, S., Westermann, M., Gröger, M., Mosig, A. S., Gresnigt, M. S., & Hube, B. (2019) · Disease Models &amp; Mechanisms · doi:10.1242/dmm.039719 · Cited by 83 · see citing works

Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD

Pierantonelli, I., Rychlicki, C., Agostinelli, L., Giordano, D. M., Gaggini, M., Fraumene, C., Saponaro, C., Manghina, V., Sartini, L., Mingarelli, E., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-11744-6 · Cited by 82 · see citing works

Effect of a multistrain probiotic on cognitive function and risk of falls in patients with cirrhosis: A randomized trial

Román, E., Nieto, J. C., Gely, C., Vidal, S., Pozuelo, M., Poca, M., Juárez, C., Guarner, C., Manichanh, C., & Soriano, G. (2019) · Hepatology Communications · doi:10.1002/hep4.1325 · Cited by 80 · see citing works

Probiotic Bacteria for Healthier Aging: Immunomodulation and Metabolism of Phytoestrogens

Landete, J. M., Gaya, P., Rodríguez, E., Langa, S., Peirotén, Á., Medina, M., & Arqués, J. L. (2017) · BioMed Research International · doi:10.1155/2017/5939818 · Cited by 76 · see citing works

Fructose liquid and solid formulations differently affect gut integrity, microbiota composition and related liver toxicity: a comparative in vivo study

Mastrocola, R., Ferrocino, I., Liberto, E., Chiazza, F., Cento, A. S., Collotta, D., Querio, G., Nigro, D., Bitonto, V., Cutrin, J. C., et al. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.02.003 · Cited by 68 · see citing works

The microbiotic highway to health—New perspective on food structure, gut microbiota, and host inflammation

Hansen, N. W., & Sams, A. (2018) · Nutrients · doi:10.3390/nu10111590 · Cited by 65 · see citing works

Welfare of cattle during transport

(AHAW), E. P. O. A. H. A. W., Nielsen, S. S., Alvarez, J., Bicout, D. J., Calistri, P., Canali, E., Drewe, J. A., Garin‐Bastuji, B., Gonzales Rojas, J. L., Gortázar Schmidt, C., et al. (2022) · EFSA Journal · doi:10.2903/j.efsa.2022.7442 · Cited by 64 · see citing works

Mediterranean Diet Adherence in People With Parkinson's Disease Reduces Constipation Symptoms and Changes Fecal Microbiota After a 5-Week Single-Arm Pilot Study

Rusch, C., Beke, M., Tucciarone, L., Nieves, C., Ukhanova, M., Tagliamonte, M. S., Mai, V., Suh, J. H., Wang, Y., Chiu, S., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.794640 · Cited by 63 · see citing works

Hydrogen sulfide improves colonic barrier integrity in DSS-induced inflammation in Caco-2 cells and mice

Zhao, H., Yan, R., Zhou, X., Ji, F., & Zhang, B. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.07.020 · Cited by 61 · see citing works

Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation

Wang, Y., Yang, J., Wang, W., Sanidad, K. Z., Cinelli, M. A., Wan, D., Hwang, S. H., Kim, D., Lee, K. S. S., Xiao, H., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916189117 · Cited by 59 · see citing works

Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera

Bourgonje, A. R., Roo-Brand, G., Lisotto, P., Sadaghian Sadabad, M., Reitsema, R. D., de Goffau, M. C., Faber, K. N., Dijkstra, G., & Harmsen, H. J. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.842911 · Cited by 47 · see citing works

Changes to the Intestinal Microbiome With Parenteral Nutrition: Review of a Murine Model and Potential Clinical Implications

Demehri, F. R., Barrett, M., & Teitelbaum, D. H. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615609904 · Cited by 53 · see citing works

Altered neural cell junctions and ion-channels leading to disrupted neuron communication in Parkinson’s disease

Choudhury, S. P., Bano, S., Sen, S., Suchal, K., Kumar, S., Nikolajeff, F., Dey, S. K., & Sharma, V. (2022) · npj Parkinson's Disease · doi:10.1038/s41531-022-00324-9 · Cited by 52 · see citing works

Effect of a polyphenol-rich dietary pattern on intestinal permeability and gut and blood microbiomics in older subjects: study protocol of the MaPLE randomised controlled trial

Guglielmetti, S., Bernardi, S., Del Bo’, C., Cherubini, A., Porrini, M., Gargari, G., Hidalgo-Liberona, N., Gonzalez-Dominguez, R., Peron, G., Zamora-Ros, R., et al. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-1472-9 · Cited by 51 · see citing works

Gut microbiota in ALS: possible role in pathogenesis?

McCombe, P. A., Henderson, R. D., Lee, A., Lee, J. D., Woodruff, T. M., Restuadi, R., McRae, A., Wray, N. R., Ngo, S., & Steyn, F. J. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1623026 · Cited by 46 · see citing works

Intestinal Permeability and Its Significance in Psychiatric Disorders—A Narrative Review and Future Perspectives

Wasiak, J., & Gawlik-Kotelnicka, O. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114459 · Cited by 47 · see citing works

Regulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition

Nam, B., Kim, S. A., Park, S. D., Kim, H. J., Kim, J. S., Bae, C. H., Kim, J. Y., Nam, W., Lee, J. L., & Sim, J. H. (2020) · PLOS ONE · doi:10.1371/journal.pone.0231268 · Cited by 35 · see citing works

Effect of dietary cellulose supplementation on gut barrier function and apoptosis in a murine model of endotoxemia

Di Caro, V., Alcamo, A. M., Cummings, J. L., Clark, R. S. B., Novak, E. A., Mollen, K. P., Morowitz, M. J., & Aneja, R. K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224838 · Cited by 32 · see citing works

Simulation of feed restriction and fasting: Effects on animal recovery and gastrointestinal permeability in unweaned Angus-Holstein calves

Pisoni, L., Devant, M., Blanch, M., Pastor, J. J., & Marti, S. (2022) · Journal of Dairy Science · doi:10.3168/jds.2021-20878 · Cited by 24 · see citing works

Carotenoids Improve Obesity and Fatty Liver Disease via Gut Microbiota: A Narrative Review

Hashemi, D., Fard, M. V., Mohammadhasani, K., Barati, M., & Nattagh‐Eshtivani, E. (2025) · Food Science &amp; Nutrition · doi:10.1002/fsn3.70092 · Cited by 15 · see citing works

The Oral–Gut–Brain Axis: From Periodontal Dysbiosis to Neuroinflammation—Mechanistic Pathways, Salivary and Intestinal Biomarkers, and Therapeutic Targets: A Narrative Review

Dumitru, C. N., Dumitru, A. O., Popa, G. V., Marcu, T., Ursu, M., Nechita, A., & Matei, N. M. (2026) · Dentistry Journal · doi:10.3390/dj14050289 · Cited by 6 · see citing works

The effects of colostrum consumption and feed restriction during marketing and transportation of male dairy beef calves: Impact on pre-transport nutritional status and on farm recovery

Pisoni, L., Devant, M., Bassols, A. M., Saco, Y., Pato, R., Pujols, J., & Marti, S. (2023) · Journal of Dairy Science · doi:10.3168/jds.2023-23374 · Cited by 6 · see citing works

Dietary Protein and Colonic Microbiota

Boudry, G., Le Huërou-Luron, I., & Michel, C. (2016) · The Molecular Nutrition of Amino Acids and Proteins · doi:10.1016/b978-0-12-802167-5.00015-3 · Cited by 5 · see citing works

Bovine Colostrum in Increased Intestinal Permeability in Healthy Athletes and Patients: A Meta-Analysis of Randomized Clinical Trials

Hajihashemi, P., Haghighatdoost, F., Kassaian, N., Hoveida, L., Tamizifar, B., Nili, H., Rahim Khorasani, M., & Adibi, P. (2024) · Digestive Diseases and Sciences · doi:10.1007/s10620-023-08219-2 · Cited by 4 · see citing works

Hepatology and Transplant Hepatology

Ahmad, J. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7085-5 · Cited by 2 · see citing works

P0320 AUTOIMMUNE HEPATITIS: MULTICENTRE DATA AT DIAGNOSIS IN 245 CHILDREN

Galoppo, C., Ciocca, M., González, T., et al. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.2004.tb12750.x

HEPATOLOGY and hepatology: The good, the bad, and the ugly

Berk, P. D. (1996) · Hepatology · doi:10.1053/jhep.1996.v24.ajhep0241530

Hepatology and Hepatology: the Good, the Bad, and the Ugly

Berk, P. D. (1996) · Hepatology · doi:10.1002/hep.510240636 · Cited by 6 · see citing works

The downstream financial effect of hepatology†

Cohen, S. M., Gundlapalli, S., Shah, A. R., et al. (2005) · Hepatology · doi:10.1002/hep.20690 · Cited by 22 · see citing works