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Inhibition of the Interferon- Inducible Protein Kinase PKR by HCV E2 Protein
Abstract
Most isolates of hepatitis C virus (HCV) infections are resistant to interferon, the only available therapy, but the mechanism underlying this resistance has not been defined. Here it is shown that the HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PKR and the translation initiation factor eIF2α, a target of PKR. E2 inhibited the kinase activity of PKR and blocked its inhibitory effect on protein synthesis and cell growth. This interaction of E2 and PKR may be one mechanism by which HCV circumvents the antiviral effect of interferon.
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Citations
Cited by
Antiviral Actions of Interferons
Samuel, C. E. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.778-809.2001 · Cited by 2,743
Mechanism of action of interferon and ribavirin in treatment of hepatitis C
Feld, J. J., & Hoofnagle, J. H. (2005) · Nature · doi:10.1038/nature04082 · Cited by 992
Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action
García, M. A., Gil, J., Ventoso, I., Guerra, S., Domingo, E., Rivas, C., & Esteban, M. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00027-06 · Cited by 818
Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease
Foy, E., Li, K., Wang, C., Sumpter, R., Ikeda, M., Lemon, S. M., & Gale, M. (2003) · Science · doi:10.1126/science.1082604 · Cited by 788
Lindsay, K. L., Trepo, C., Heintges, T., Shiffman, M. L., Gordon, S. C., Hoefs, J. C., Schiff, E. R., Goodman, Z. D., Laughlin, M., Yao, R., et al. (2001) · Hepatology · doi:10.1053/jhep.2001.26371 · Cited by 668
Metadata
- Authors
- Taylor, D. R., Shi, S. T., Romano, P. R., Barber, G. N., & Lai, M. M. C.
- Venue
- Science
- Published
- 1999-07-02
- Volume
- 285
- Issue
- 5424
- Pages
- 107-110
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059457521
- Cited by
- 733
- References
- 0
- FWCI
- 32.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Inhibition of the Interferon- Inducible Protein Kinase PKR by HCV E2 Protein. https://app.cochat.ai/papers/10.1126/science.285.5424.107
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- Taylor, D. R., Shi, S. T., Romano, P. R., Barber, G. N., & Lai, M. M. C. (1999). Inhibition of the Interferon- Inducible Protein Kinase PKR by HCV E2 Protein. Science. https://doi.org/10.1126/science.285.5424.107
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
