The DOI matches its Crossref record.
GABA and Its Agonists Improved Visual Cortical Function in Senescent Monkeys
Abstract
Human cerebral cortical function degrades during old age. Much of this change may result from a degradation of intracortical inhibition during senescence. We used multibarreled microelectrodes to study the effects of electrophoretic application of γ-aminobutyric acid (GABA), the GABA type a (GABAa) receptor agonist muscimol, and the GABAa receptor antagonist bicuculline, respectively, on the properties of individual V1 cells in old monkeys. Bicuculline exerted a much weaker effect on neuronal responses in old than in young animals, confirming a degradation of GABA-mediated inhibition. On the other hand, the administration of GABA and muscimol resulted in improved visual function. Many treated cells in area V1 of old animals displayed responses typical of young cells. The present results have important implications for the treatment of the sensory, motor, and cognitive declines that accompany old age.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Sugiyama, S., Di Nardo, A. A., Aizawa, S., Matsuo, I., Volovitch, M., Prochiantz, A., & Hensch, T. K. (2008) · Cell · doi:10.1016/j.cell.2008.05.054 · Cited by 491
Gamma-aminobutyric acid as a bioactive compound in foods: A review
Diana, M., Quílez, J., & Rafecas, M. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.07.004 · Cited by 473
Changes in the structural complexity of the aged brain
Dickstein, D. L., Kabaso, D., Rocher, A. B., Luebke, J. I., Wearne, S. L., & Hof, P. R. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00289.x · Cited by 460
Production of Gamma-Aminobutyric Acid from Lactic Acid Bacteria: A Systematic Review
Cui, Y., Miao, K., Niyaphorn, S., & Qu, X. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030995 · Cited by 451
Sieber, F. E., Zakriya, K. J., Gottschalk, A., Blute, M.-R., Lee, H. B., Rosenberg, P. B., & Mears, S. C. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2009.0469 · Cited by 417
Metadata
- Authors
- Leventhal, A. G., Wang, Y., Pu, M., Zhou, Y., & Ma, Y.
- Venue
- Science
- Published
- 2003-05-02
- Volume
- 300
- Issue
- 5620
- Pages
- 812-815
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2168467995
- Cited by
- 557
- References
- 0
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: GABA and Its Agonists Improved Visual Cortical Function in Senescent Monkeys. https://app.cochat.ai/papers/10.1126/science.1082874
- The paper
- Leventhal, A. G., Wang, Y., Pu, M., Zhou, Y., & Ma, Y. (2003). GABA and Its Agonists Improved Visual Cortical Function in Senescent Monkeys. Science. https://doi.org/10.1126/science.1082874
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
