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Chromosomal Instability and Tumors Promoted by DNA Hypomethylation
Abstract
Human tumors often display changes in DNA methylation, including both genome-wide hypomethylation and site-specific hypermethylation ( [1][1], [2][2] ). In mice, DNA hypomethylation is sufficient to induce T cell lymphomas with consistent gain of chromosome 15 ( [3][3] ), indicating that genome-wide
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Cited by
Gene Silencing in Cancer in Association with Promoter Hypermethylation
Herman, J. G., & Baylin, S. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmra023075 · Cited by 3,422
Sharma, S., Kelly, T. K., & Jones, P. A. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp220 · Cited by 2,637
Fraga, M. F., Ballestar, E., Villar-Garea, A., Boix-Chornet, M., Espada, J., Schotta, G., Bonaldi, T., Haydon, C., Ropero, S., Petrie, K., et al. (2005) · Nature Genetics · doi:10.1038/ng1531 · Cited by 1,923
Phenotypic plasticity and the epigenetics of human disease
Feinberg, A. P. (2007) · Nature · doi:10.1038/nature05919 · Cited by 1,613
Induction of tumors in mice by genomic hypomethylation
Gaudet, F., Hodgson, J. G., Eden, A., Jackson-Grusby, L., Dausman, J., Gray, J. W., Leonhardt, H., & Jaenisch, R. (2003) · Science · doi:10.1126/science.1083558 · Cited by 1,499
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Metadata
- Authors
- Eden, A., Gaudet, F., Waghmare, A., & Jaenisch, R.
- Venue
- Science
- Published
- 2003-04-18
- Volume
- 300
- Issue
- 5618
- Pages
- 455-455
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2062093164
- Cited by
- 1,399
- References
- 0
- FWCI
- 20.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Eden, A., Gaudet, F., Waghmare, A., & Jaenisch, R. (2003). Chromosomal Instability and Tumors Promoted by DNA Hypomethylation. Science. https://doi.org/10.1126/science.1083557
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
