Epigenetics in cancer

Chromatin modifications and their function

Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · cited 7× · see citing works

Prospective identification of tumorigenic breast cancer cells

Al‐Hajj, M., Wicha, M. S., Benito‐Hernández, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,388 · see citing works

Translating the Histone Code

Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756 · see citing works

MicroRNA expression profiles classify human cancers

Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,497 · see citing works

Crystal structure of the nucleosome core particle at 2.8 Å resolution

Luger, K., Mäder, A. W., Richmond, R. K., Sargent, D. F., & Richmond, T. J. (1997) · Nature · doi:10.1038/38444 · Cited by 9,466 · see citing works

DNA methylation patterns and epigenetic memory

Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124 · see citing works

High-Resolution Profiling of Histone Methylations in the Human Genome

Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845 · see citing works

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143 · see citing works

MicroRNAs: small RNAs with a big role in gene regulation

He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 5,910 · see citing works

The fundamental role of epigenetic events in cancer

Jones, P. A., & Baylin, S. B. (2002) · Nature Reviews Genetics · doi:10.1038/nrg816 · Cited by 5,648 · see citing works

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361 · see citing works

The Epigenomics of Cancer

Jones, P. A., & Baylin, S. B. (2007) · Cell · doi:10.1016/j.cell.2007.01.029 · Cited by 4,515 · see citing works

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129 · see citing works

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051 · see citing works

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Nan, X., Ng, H.-H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., & Bird, A. (1998) · Nature · doi:10.1038/30764 · Cited by 3,440 · see citing works

Epigenetics in human disease and prospects for epigenetic therapy

Egger, G., Liang, G., Aparicio, A., & Jones, P. A. (2004) · Nature · doi:10.1038/nature02625 · Cited by 3,232 · see citing works

DNA methylation landscapes: Provocative insights from epigenomics

Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039 · see citing works

microRNAs as oncogenes and tumor suppressors

Zhang, B., Pan, X., Cobb, G. P., & Anderson, T. A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.028 · Cited by 2,755 · see citing works

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., & Wolffe, A. P. (1998) · Nature Genetics · doi:10.1038/561 · Cited by 2,734 · see citing works

MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells

Chan, J. A., Krichevsky, A. M., & Kosik, K. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0137 · Cited by 2,557 · see citing works

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Haberland, M., Montgomery, R. L., & Olson, E. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2485 · Cited by 2,541 · see citing works

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

Feinberg, A. P., & Vogelstein, B. (1983) · Nature · doi:10.1038/301089a0 · Cited by 2,430 · see citing works

Cancer-epigenetics comes of age

Jones, P. A., & Laird, P. W. (1999) · Nature Genetics · doi:10.1038/5947 · Cited by 2,344 · see citing works

Combinatorial patterns of histone acetylations and methylations in the human genome

Wang, Z., Zang, C., Rosenfeld, J. A., Schones, D. E., Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Peng, W., Zhang, M. Q., et al. (2008) · Nature Genetics · doi:10.1038/ng.154 · Cited by 2,331 · see citing works

Linking DNA methylation and histone modification: patterns and paradigms

Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267 · see citing works

The Polycomb group protein EZH2 directly controls DNA methylation

Viré, E., Brenner, C., Deplus, R., Blanchon, L., Fraga, M., Didelot, C., Morey, L., Van Eynde, A., Bernard, D., Vanderwinden, J.-M., et al. (2006) · Nature · doi:10.1038/nature04431 · Cited by 2,204 · see citing works

The Mammalian Epigenome

Bernstein, B. E., Meissner, A., & Lander, E. S. (2007) · Cell · doi:10.1016/j.cell.2007.01.033 · Cited by 2,086 · see citing works

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

Weisenberger, D. J., Siegmund, K. D., Campan, M., Young, J. P., Long, T. I., Faasse, M. A., Kang, G. H., Widschwendter, M., Weener, D., Buchanan, D. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1834 · Cited by 1,990 · see citing works

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

Fraga, M. F., Ballestar, E., Villar‐Garea, A., Boix-Chornet, M., Espada, J., Schotta, G., Bonaldi, T., Haydon, C. E., Ropero, S., Petrie, K. R., et al. (2005) · Nature Genetics · doi:10.1038/ng1531 · Cited by 1,926 · see citing works

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

Cameron, E. E., Bachman, K. E., Myöhänen, S., Herman, J. G., & Baylin, S. B. (1999) · Nature Genetics · doi:10.1038/5047 · Cited by 1,857 · see citing works

The epigenetic progenitor origin of human cancer

Feinberg, A. P., OHLSSON, R. I., & Henikoff, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1748 · Cited by 1,851 · see citing works

CLINICAL CANCER RESEARCH

Smithers, D. W. (1956) · The Lancet · doi:10.1016/s0140-6736(56)91184-9 · Cited by 1,796 · see citing works

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

Metzger, E., Wissmann, M., Yin, N., Müller, J. M., Schneider, R., Peters, A. H. F. M., Günther, T., Buettner, R., & Schüle, R. (2005) · Nature · doi:10.1038/nature04020 · Cited by 1,741 · see citing works

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

Fabbri, M., Garzon, R., Cimmino, A., Liu, Z., Zanesi, N. A. O., Callegari, E., Liu, S., Alder, H., Costinean, S., Fernandez-Cymering, C., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707628104 · Cited by 1,676 · see citing works

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

Baylin, S. B., & Ohm, J. E. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1799 · Cited by 1,632 · see citing works

Comprehensive analysis of CpG islands in human chromosomes 21 and 22

Takai, D., & Jones, P. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052410099 · Cited by 1,507 · see citing works

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

Eden, A., Gaudet, F., Waghmare, A., & Jaenisch, R. (2003) · Science · doi:10.1126/science.1083557 · Cited by 1,401 · see citing works

Dynamic Regulation of Nucleosome Positioning in the Human Genome

Schones, D. E., Cui, K., Cuddapah, S., Roh, T., Barski, A., Wang, Z., Wei, G., & Zhao, K. (2008) · Cell · doi:10.1016/j.cell.2008.02.022 · Cited by 1,396 · see citing works

Chromatin signatures of pluripotent cell lines

Azuara, V., Perry, P., Sauer, S., Spivakov, M., Jørgensen, H. F., John, R. M., Gouti, M., Casanova, M., Warnes, G., Merkenschlager, M., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1403 · Cited by 1,357 · see citing works

DNA methylation profiling of human chromosomes 6, 20 and 22

Eckhardt, F., Lewin, J., Cortese, R., Rakyan, V. K., Attwood, J., Burger, M., Burton, J. H., Cox, T. V., Davies, R., Down, T. A., et al. (2006) · Nature Genetics · doi:10.1038/ng1909 · Cited by 1,350 · see citing works

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

Saito, Y., Liang, G., Egger, G., Friedman, J. M., Chuang, J. C., Coetzee, G. A., & Jones, P. A. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.020 · Cited by 1,328 · see citing works

Epigenetic therapy of cancer: past, present and future

Yoo, C. B., & Jones, P. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1930 · Cited by 1,296 · see citing works

MLL translocations, histone modifications and leukaemia stem-cell development

Krivtsov, A., & Armstrong, S. (2007) · Nature Reviews. Cancer · doi:10.1038/nrc2253 · Cited by 1,294 · see citing works

Suv39h-Mediated Histone H3 Lysine 9 Methylation Directs DNA Methylation to Major Satellite Repeats at Pericentric Heterochromatin

Lehnertz, B., Ueda, Y., Derijck, A. A. H. A., Braunschweig, U., Perez-Burgos, L., Kubicek, S., Chen, T., Li, E., Jenuwein, T., & Peters, A. H. F. M. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00432-9 · Cited by 1,248 · see citing works

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

Schlesinger, Y., Straussman, R., Keshet, I., Farkash, S., Hecht, M., Zimmerman, J., Eden, E., Yakhini, Z., Ben-Shushan, E., Reubinoff, B. E., et al. (2007) · Nature Genetics · doi:10.1038/ng1950 · Cited by 1,226 · see citing works

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

Wysocka, J., Swigut, T., Xiao, H., Milne, T. A., Kwon, S. Y., Landry, J., Kauer, M., Tackett, A. J., Chait, B. T., Badenhorst, P. W., et al. (2006) · Nature · doi:10.1038/nature04815 · Cited by 1,186 · see citing works

DNA methylation and gene silencing in cancer

Baylin, S. B. (2005) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0354 · Cited by 1,156 · see citing works

Epigenetic stem cell signature in cancer

Widschwendter, M., Fiegl, H., Egle, D., Mueller-Holzner, E., Spizzo, G., Marth, C., Weisenberger, D. J., Campan, M., Young, J., Jacobs, I., et al. (2007) · Nature Genetics · doi:10.1038/ng1941 · Cited by 1,143 · see citing works

Genome-Scale Identification of Nucleosome Positions in S. cerevisiae

Yuan, G., Liu, Y.-J., Dion, M. F., Slack, M. D., Wu, L. F., Altschuler, S. J., & Rando, O. J. (2005) · Science · doi:10.1126/science.1112178 · Cited by 1,139 · see citing works

A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

Ohm, J. E., McGarvey, K. M., Yu, X., Cheng, L., Schuebel, K. E., Cope, L., Mohammad, H. P., Chen, W., Daniel, V. C., Yu, W., et al. (2007) · Nature Genetics · doi:10.1038/ng1972 · Cited by 1,130 · see citing works

miRiad Roles for the miR-17-92 Cluster in Development and Disease

Mendell, J. T. (2008) · Cell · doi:10.1016/j.cell.2008.04.001 · Cited by 1,086 · see citing works

A microRNA DNA methylation signature for human cancer metastasis

Lujambio, A., Calin, G. A., Villanueva, A., Ropero, S., Sánchez‐Céspedes, M., Blanco, D., Montuenga, L. M., Rossi, S., Nicoloso, M. S., Faller, W. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803055105 · Cited by 1,078 · see citing works

Nucleosome positioning and gene regulation: advances through genomics

Jiang, C., & Pugh, B. F. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2522 · Cited by 1,059 · see citing works

The Methyl-CpG-binding Protein MeCP2 Links DNA Methylation to Histone Methylation

Fuks, F., Hurd, P. J., Wolf, D., Nan, X., Bird, A. P., & Kouzarides, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210256200 · Cited by 994 · see citing works

A direct link between core histone acetylation and transcriptionally active chromatin.

Hebbes, T. R., Thorne, A. W., & Crane‐Robinson, C. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02956.x · Cited by 921 · see citing works

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

Tan, J., Yang, X., Zhuang, L., Jiang, X., Chen, W., Lee, P. L., Karuturi, R. K. M., Tan, P. B. O., Liu, E. T., & Yu, Q. (2007) · Genes & Development · doi:10.1101/gad.1524107 · Cited by 895 · see citing works

MicroRNAs and Cancer: Short RNAs Go a Long Way

Ventura, A., & Jacks, T. (2009) · Cell · doi:10.1016/j.cell.2009.02.005 · Cited by 893 · see citing works

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

Wang, J., Hevi, S., Kurash, J. K., Lei, H., Gay, F., Bajko, J., Su, H., Sun, W., Chang, H., Xu, G., et al. (2008) · Nature Genetics · doi:10.1038/ng.268 · Cited by 827 · see citing works

DNA hypomethylation and human diseases

Wilson, A. S., Power, B. E., & Molloy, P. L. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.08.007 · Cited by 804 · see citing works

Relaxation of imprinted genes in human cancer

Rainier, S. R., Johnson, L. A., Dobry, C. J., Ping, A. J., Grundy, P. E., & Feinberg, A. P. (1993) · Nature · doi:10.1038/362747a0 · Cited by 790 · see citing works

Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor

Croce, L. D., Raker, V. A., Corsaro, M., Fazi, F., Fanelli, M., Faretta, M., Fuks, F., Lo‐Coco, F., Kouzarides, T., Nervi, C., et al. (2002) · Science · doi:10.1126/science.1065173 · Cited by 786 · see citing works

Stem Cells and Cancer

Valk-Lingbeek, M. E., Bruggeman, S. W. M., & van Lohuizen, M. (2004) · Cell · doi:10.1016/j.cell.2004.08.005 · Cited by 743 · see citing works

Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk

Cui, H., Cruz-Correa, M. R., Giardiello, F. M., Hutcheon, D. F., Kafonek, D. R., Brandenburg, S. A., Wu, Y., He, X., Powe, N. R., & Feinberg, A. P. (2003) · Science · doi:10.1126/science.1080902 · Cited by 735 · see citing works

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour

Ogawa, O., Eccles, M. R., Szeto, J., McNoe, L. A., Yun, K., Maw, M. A., Smith, P. J., & Reeve, A. E. (1993) · Nature · doi:10.1038/362749a0 · Cited by 706 · see citing works

A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genomePreprint

Mavrich, T. N., Ioshikhes, I. P., Venters, B. J., Jiang, C., Tomsho, L. P., Qi, J., Schuster, S. C., Albert, I. U., & Pugh, B. F. (2008) · Genome Research · doi:10.1101/gr.078261.108 · Cited by 673 · see citing works

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and diseasePreprint

Cloos, P. A., Christensen, J., Agger, K., & Helin, K. (2008) · Genes & Development · doi:10.1101/gad.1652908 · Cited by 664 · see citing works

Genetic and epigenetic regulators of pluripotency.

Surani, M., Hayashi, K., & Hájková, P. (2007) · Cell · doi:10.1016/j.cell.2007.02.010 · Cited by 648 · see citing works

A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci

Illingworth, R. S., Kerr, A. R. W., DeSousa, D., Jørgensen, H. F., Ellis, P., Stalker, J., Jackson, D. K., Clee, C. M., Plumb, R. W., Rogers, J., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060022 · Cited by 637 · see citing works

Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells

Wen, B., Wu, H., Shinkai, Y., Irizarry, R. A., & Feinberg, A. P. (2009) · Nature Genetics · doi:10.1038/ng.297 · Cited by 615 · see citing works

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.Preprint

Watt, F., & Molloy, P. L. (1988) · Genes & Development · doi:10.1101/gad.2.9.1136 · Cited by 611 · see citing works

Histone lysine demethylases: emerging roles in development, physiology and disease

Shi, Y. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2218 · Cited by 603 · see citing works

Epigenetic Silencing of MicroRNA-34b/c and B-Cell Translocation Gene 4 Is Associated with CpG Island Methylation in Colorectal Cancer

Toyota, M., Suzuki, H., Sasaki, Y., Maruyama, R., Imai, K., Shinomura, Y., & Tokino, T. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0325 · Cited by 600 · see citing works

Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks

Zilberman, D., Coleman-Derr, D., Ballinger, T., & Henikoff, S. (2008) · Nature · doi:10.1038/nature07324 · Cited by 593 · see citing works

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

Miranda, T. B., Cortez, C. C., Yoo, C. B., Liang, G., Abe, M., Kelly, T. K., Márquez, V. E., & Jones, P. A. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0013 · Cited by 588 · see citing works

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

Greger, V., Passarge, E., H�pping, W., Messmer, E. P., & Horsthemke, B. (1989) · Human Genetics · doi:10.1007/bf00286709 · Cited by 573 · see citing works

The SWI/SNF complex and cancer

Reisman, D., Glaros, S., & Thompson, E. A. (2009) · Oncogene · doi:10.1038/onc.2009.4 · Cited by 567 · see citing works

Methylation-Sensitive Sequence-Specific DNA Binding by the c-Myc Basic Region

Prendergast, G. C., & Ziff, E. B. (1991) · Science · doi:10.1126/science.1987636 · Cited by 565 · see citing works

Nucleosome stability mediated by histone variants H3.3 and H2A.ZPreprint

Jin, C., & Felsenfeld, G. (2007) · Genes & Development · doi:10.1101/gad.1547707 · Cited by 544 · see citing works

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

Zhao, Q., Rank, G., Tan, Y., Li, H., Moritz, R. L., Simpson, R. J., Cerruti, L., Curtis, D. J., Patel, D. J., Allis, C. D., et al. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1568 · Cited by 539 · see citing works

Polycomb/Trithorax response elements and epigenetic memory of cell identity

Ringrose, L., & Paro, R. (2007) · Development · doi:10.1242/dev.02723 · Cited by 515 · see citing works

Upregulation and Nuclear Recruitment of HDAC1 in Hormone Refractory Prostate Cancer

Halkidou, K., Gaughan, L., Cook, S., Leung, H. Y., Neal, D. E., & Robson, C. N. (2004) · The Prostate · doi:10.1002/pros.20022 · Cited by 515 · see citing works

The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases

Yang, X. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh252 · Cited by 513 · see citing works

Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome

Liang, G., Lin, J., Wei, V., Yoo, C. B., Cheng, J., Nguyen, C. T., Weisenberger, D. J., Egger, G., Takai, D., Gonzales, F. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401866101 · Cited by 485 · see citing works

MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation

Dorsett, Y., McBride, K. M., Janković, M., Gazumyan, A., Thai, T., Robbiani, D. F., Virgilio, M. D., Reina‐San‐Martin, B., Heidkamp, G. F., Schwickert, T. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.002 · Cited by 456 · see citing works

Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy

Schulte, J. H., Lim, S., Schramm, A. R., Friedrichs, N., Köster, J., Versteeg, R., Øra, I., Pajtler, K. W., Klein‐Hitpaß, L., Kuhfittig-Kulle, S., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-1735 · Cited by 447 · see citing works

Role for DNA methylation in the control of cell type–specific maspin expression

Futscher, B. W., Oshiro, M. M., Wozniak, R. J., Holtan, N., Hanigan, C. L., Duan, H., & Domann, F. E. (2002) · Nature Genetics · doi:10.1038/ng886 · Cited by 442 · see citing works

G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription

Tachibana, M., Matsumura, Y., Fukuda, M., Kimura, H., & Shinkai, Y. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.192 · Cited by 431 · see citing works

Histone deacetylase inhibitors: Mechanisms of cell death and promise in combination cancer therapy

Carew, J. S., Giles, F. J., & Nawrocki, S. T. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.037 · Cited by 421 · see citing works

5-Methylcytosine, Gene Regulation, and Cancer

Riggs, A. D., & Jones, P. A. (1983) · Advances in cancer research · doi:10.1016/s0065-230x(08)60678-8 · Cited by 420 · see citing works

Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band

Frigola, J., Song, J. Z., Stirzaker, C., Hinshelwood, R. A., Peinado, M. A., & Clark, S. J. (2006) · Nature Genetics · doi:10.1038/ng1781 · Cited by 409 · see citing works

Dynamic Remodeling of Individual Nucleosomes Across a Eukaryotic Genome in Response to Transcriptional Perturbation

Shivaswamy, S., Bhinge, A., Zhao, Y., Jones, S. J. M., Hirst, M., & Iyer, V. R. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060065 · Cited by 401 · see citing works

Epigenetic Control of Mouse Oct-4 Gene Expression in Embryonic Stem Cells and Trophoblast Stem Cells

Hattori, N., Nishino, K., Ko, Y., Hattori, N., Ohgane, J., Tanaka, S., & Shiota, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309002200 · Cited by 397 · see citing works

Biochimica et biophysica acta. Protein structure and molecular enzymology

ScienceDirect (2002) · Cited by 395 · see citing works

Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine.

Nguyen, C. T., Weisenberger, D. J., Velicescu, M., Gonzales, F. A., Lin, J., Liang, G., & Jones, P. A. (2002) · PubMed · Cited by 383 · see citing works

Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.

Reisman, D., Sciarrotta, J., Wang, W., Funkhouser, W. K., & Weissman, B. E. (2003) · PubMed · Cited by 381 · see citing works

The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2

Friedman, J. M., Liang, G., Liu, C.-C., Wolff, E. M., Tsai, Y., Ye, W., Zhou, X. J., & Jones, P. A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3114 · Cited by 381 · see citing works

Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line

Gal‐Yam, E. N., Egger, G., Iniguez, L., Holster, H., Einarsson, S. O., Zhang, X., Lin, J., Liang, G., Jones, P. A., & Tanay, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806437105 · Cited by 380 · see citing works

Reprogramming of a melanoma genome by nuclear transplantationPreprint

Hochedlinger, K., Blelloch, R. H., Brennan, C. W., Yamada, Y., Kim, M., Chin, L., & Jaenisch, R. (2004) · Genes & Development · doi:10.1101/gad.1213504 · Cited by 369 · see citing works

Co‐operation and communication between the human maintenance and de novo DNA (cytosine‐5) methyltransferases

Kim, G., Ni, J., Kelesoglu, N., Roberts, R. J., & Pradhan, S. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf401 · Cited by 358 · see citing works

PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegansPreprint

Dann, C. T., Subramaniam, K., Dunn, M. A., & Seydoux, G. (2001) · Genes & Development · doi:10.1101/gad.876201 · Cited by 357 · see citing works

Increased expression of histone deacetylase 2 is found in human gastric cancer

SONG, J., Noh, J. H., LEE, J. H., Eun, J. W., Ahn, Y. M., Kim, S. Y., Lee, S. H., Park, W. S., Yoo, N. J., Lee, J. Y., et al. (2005) · Apmis · doi:10.1111/j.1600-0463.2005.apm_04.x · Cited by 347 · see citing works

Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice

Howard, G., Eiges, R., Gaudet, F., Jaenisch, R., & Eden, A. (2007) · Oncogene · doi:10.1038/sj.onc.1210631 · Cited by 344 · see citing works

H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment

Creyghton, M. P., Markoulaki, S., Levine, S. S., Hanna, J. H., Lodato, M. A., Sha, K., Young, R. A., Jaenisch, R., & Boyer, L. A. (2008) · Cell · doi:10.1016/j.cell.2008.09.056 · Cited by 340 · see citing works

Chromosomal Instability Correlates with Genome-wide DNA Demethylation in Human Primary Colorectal Cancers

Rodríguez, J., Frigola, J., Vendrell, E., Risques, R., Fraga, M. F., Morales, C., Moreno, V. R., Esteller, M., Capellá, G., Ribas, M., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0293 · Cited by 337 · see citing works

Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment

Constantinides, P. G., Jones, P. A., & Gevers, W. (1977) · Nature · doi:10.1038/267364a0 · Cited by 335 · see citing works

Loss of Imprinting of Igf2 Alters Intestinal Maturation and Tumorigenesis in Mice

Sakatani, T., Kaneda, A., Iacobuzio–Donahue, C. A., Carter, M. G., Witzel, S. D. B., Okano, H., Ko, M. S. H., OHLSSON, R. I., Longo, D. L., & Feinberg, A. P. (2005) · Science · doi:10.1126/science.1108080 · Cited by 322 · see citing works

Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells

Estève, P., Chin, H. G., Benner, J. S., Feehery, G. R., Samaranayake, M., Horwitz, G. A., Jacobsen, S. E., & Pradhan, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810362106 · Cited by 319 · see citing works

Preferential response of cancer cells to zebularine

Cheng, J., Yoo, C. B., Weisenberger, D. J., Chuang, J. C., Wozniak, C., Liang, G., Márquez, V. E., Greer, S. B., Orntoft, T. F., Thykjær, T., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.023 · Cited by 319 · see citing works

Mechanisms of microRNA deregulation in human cancer

Deng, S., Calin, G. A., Croce, C. M., Coukos, G., & Zhang, L. (2008) · Cell Cycle · doi:10.4161/cc.7.17.6597 · Cited by 305 · see citing works

Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing

Kaipananickal, H., Chow, M. Z. Y., Baker, E. K., Pal, S., Bassal, S., Brasacchio, D., Wang, L., Craig, J. M., Jones, P. L., Sif, S., et al. (2005) · Nature Genetics · doi:10.1038/ng1516 · Cited by 305 · see citing works

Histone variants meet their match

Sarma, K., & Reinberg, D. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1567 · Cited by 292 · see citing works

Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer.

Belinsky, S. A., Klinge, D. M., Stidley, C. A., Issa, J. J., Herman, J. G., March, T. H., & Baylin, S. B. (2003) · PubMed · Cited by 291 · see citing works

Characterization of human embryonic stem cells with features of neoplastic progression

Werbowetski‐Ogilvie, T. E., Bosse, M. M., Stewart, M. H., Schnerch, A., Ramos–Mejía, V., Rouleau, A., Wynder, T., Smith, M.-J., Dingwall, S., Carter, T., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1516 · Cited by 278 · see citing works

Epigenetic Activation of Tumor Suppressor MicroRNAs in Human Cancer Cells

Saito, Y., & Jones, P. M. (2006) · Cell Cycle · doi:10.4161/cc.5.19.3340 · Cited by 270 · see citing works

H2A.Z: View from the Top

Zlatanova, J. S., & Thakar, A. (2008) · Structure · doi:10.1016/j.str.2007.12.008 · Cited by 267 · see citing works

An evaluation of new criteria for CpG islands in the human genome as gene markers

Wang, Y., & Leung, F. C. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth059 · Cited by 267 · see citing works

GATA-4 and GATA-5 Transcription Factor Genes and Potential Downstream Antitumor Target Genes Are Epigenetically Silenced in Colorectal and Gastric Cancer

Akiyama, Y., Watkins, N., Suzuki, H., Jair, K.-W., van Engeland, M., Esteller, M., Sakai, H., Ren, C.-Y., Yuasa, Y., Herman, J. G., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8429-8439.2003 · Cited by 246 · see citing works

Epigenetic Silencing of the p16 Tumor Suppressor Is Associated with Loss of CTCF Binding and a Chromatin Boundary

Witcher, M., & Emerson, B. M. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.001 · Cited by 235 · see citing works

Downregulation of Histone H3 Lysine 9 Methyltransferase G9a Induces Centrosome Disruption and Chromosome Instability in Cancer Cells

Kondo, Y., Shen, L., Ahmed, S., Boumber, Y., Sekido, Y., Haddad, B. R., & Issa, J. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002037 · Cited by 235 · see citing works

ATP-Dependent Chromatin Remodeling

Smith, C. L., & Peterson, C. L. (2004) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)65004-6 · Cited by 225 · see citing works

Role of Nucleosomal Occupancy in the Epigenetic Silencing of the MLH1 CpG Island

Lin, J., Jeong, S., Liang, G., Takai, D., Fatemi, M., Tsai, Y., Egger, G., Gal‐Yam, E. N., & Jones, P. A. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.10.014 · Cited by 206 · see citing works

Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas

Kondo, Y., Shen, L., Suzuki, S., Kurokawa, T., Masuko, K., Tanaka, Y., Kato, H., Mizuno, Y., Yokoe, M., Sugauchi, F., et al. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00141.x · Cited by 205 · see citing works

The ICF syndrome, a DNA methyltransferase 3B deficiency and immunodeficiency disease

Ehrlich, M. (2003) · Clinical Immunology · doi:10.1016/s1521-6616(03)00201-8 · Cited by 203 · see citing works

A Blueprint for a Human Epigenome Project: The AACR Human Epigenome Workshop

Jones, P. A., & Martienssen, R. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-3865 · Cited by 169 · see citing works

Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells

Klisovic, M. I., Maghraby, E. A., Parthun, M. R., et al. (2003) · Leukemia · doi:10.1038/sj.leu.2402776 · Cited by 146 · see citing works

Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissues.

Matsubayashi, H., Sato, N., Fukushima, N., Yeo, C. J., Walter, K., Brune, K. A., Şahin, F., Hruban, R. H., & Goggins, M. (2003) · PubMed · Cited by 131 · see citing works

MBD3, a Component of the NuRD Complex, Facilitates Chromatin Alteration and Deposition of Epigenetic Marks

Morey, L., Brenner, C., Fazi, F., Villa, R., Gutiérrez, A., Buschbeck, M., Nervi, C., Minucci, S., Fuks, F., & Croce, L. D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00467-08 · Cited by 124 · see citing works

The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells

Naidu, S. R., Love, I. M., Imbalzano, A. N., Grossman, S. R., & Androphy, E. J. (2009) · Oncogene · doi:10.1038/onc.2009.121 · Cited by 122 · see citing works

Decitabine and its role in the treatment of hematopoietic malignancies

Plimack, E. R., Kantarjian, H. M., & Issa, J. J. (2007) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190701471981 · Cited by 104 · see citing works

The role of microRNAs in normal hematopoiesis and hematopoietic malignancies

Kluiver, J. L., Kroesen, B. J., Poppema, S., & van den Berg, A. (2006) · Leukemia · doi:10.1038/sj.leu.2404387 · Cited by 100 · see citing works

Chromatin, cancer and drug therapies

Cortez, C. C., & Jones, P. A. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.07.006 · Cited by 87 · see citing works

Loss of the hSNF5 Gene Concomitantly Inactivates p21CIP/WAF1 and p16INK4a Activity Associated with Replicative Senescence in A204 Rhabdoid Tumor Cells

Chai, J., Charboneau, A. L., Betz, B. L., & Weissman, B. E. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1896 · Cited by 84 · see citing works

Comment on "Chromosomal Instability and Tumors Promoted by DNA Hypomethylation" and "Induction of Tumors in Mice by Genomic Hypomethylation"

Yang, A. S., Estecio, M. R., Garcia‐Manero, G., Kantarjian, H. M., & Issa, J. J. (2003) · Science · doi:10.1126/science.1089523 · Cited by 72 · see citing works

Constitutive Nucleosome Depletion and Ordered Factor Assembly at the GRP78 Promoter Revealed by Single Molecule Footprinting

Gal‐Yam, E. N., Jeong, S., Tanay, A., Egger, G., Lee, A. S., & Jones, P. A. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020160 · Cited by 70 · see citing works

Regulation of gene expression and cellular proliferation by histone H2A.ZThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

Svotelis, A., Gévry, N. Y., & Gaudreau, L. R. (2009) · Biochemistry and Cell Biology · doi:10.1139/o08-138 · Cited by 59 · see citing works

Epigenetic reprogramming in mammalian reproduction: Contribution from histone variants

Santenard, A., & Torres‐Padilla, M. (2009) · Epigenetics · doi:10.4161/epi.4.2.7838 · Cited by 59 · see citing works

Promoter Hypermethylation of the RUNX3 Gene in Esophageal Squamous Cell Carcinoma

Long, C., Yin, B., Lu, Q., et al. (2007) · Cancer Investigation · doi:10.1080/07357900701561131 · Cited by 57 · see citing works

Adiposity and Age are Statistically Related to EnhancedRASSF1ATumor Suppressor Gene Promoter Methylation in Normal Autopsy Kidney Tissue

Peters, I., Vaske, B., Albrecht, K., Kuczyk, M. A., Udo Jonas, A., & Serth, J. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0203 · Cited by 43 · see citing works

Regulation of chromatin by histone modifications

Bannister, A. J., & Kouzarides, T. (2011) · Cell Research · doi:10.1038/cr.2011.22 · Cited by 6,012 · see citing works

Mechanisms of Diabetic Complications

Forbes, J. M., & Cooper, M. E. (2013) · Physiological Reviews · doi:10.1152/physrev.00045.2011 · Cited by 2,890 · see citing works

Idiopathic pulmonary fibrosis

King, T. E., Pardo, A., & Selman, M. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60052-4 · Cited by 2,194 · see citing works

Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

Lin, Y., Xu, J., & Lan, H. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0760-3 · Cited by 1,398 · see citing works

Sensitive tumour detection and classification using plasma cell-free DNA methylomes

Shen, S. Y., Singhania, R., Fehringer, G., Chakravarthy, A., Roehrl, M. H. A., Chadwick, D., Zuzarte, P. C., Borgida, A., Wang, T. T., Li, T., et al. (2018) · Nature · doi:10.1038/s41586-018-0703-0 · Cited by 983 · see citing works

Evaluation of the Infinium Methylation 450K technology

Dedeurwaerder, S., Defrance, M., Calonne, E., Denis, H., Sotiriou, C., & Fuks, F. (2011) · Epigenomics · doi:10.2217/epi.11.105 · Cited by 569 · see citing works

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

Delcuve, G. P., Khan, D. H., & Davie, J. R. (2012) · Clinical Epigenetics · doi:10.1186/1868-7083-4-5 · Cited by 505 · see citing works

Environmental epigenetics: prospects for studying epigenetic mediation of exposure–response relationships

Cortessis, V. K., Thomas, D. C., Levine, A. J., Breton, C. V., Mack, T. M., Siegmund, K. D., Haile, R. W., & Laird, P. W. (2012) · Human Genetics · doi:10.1007/s00439-012-1189-8 · Cited by 319 · see citing works

Epigenetic Epidemiology of Common Complex Disease: Prospects for Prediction, Prevention, and Treatment

Relton, C. L., & Davey Smith, G. (2010) · PLoS Medicine · doi:10.1371/journal.pmed.1000356 · Cited by 254 · see citing works

Disease-Associated Short Tandem Repeats Co-localize with Chromatin Domain Boundaries

Sun, J. H., Zhou, L., Emerson, D. J., Phyo, S. A., Titus, K. R., Gong, W., Gilgenast, T. G., Beagan, J. A., Davidson, B. L., Tassone, F., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.005 · Cited by 249 · see citing works

An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy

Millan, M. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.015 · Cited by 229 · see citing works

Pluronics and MDR reversal: an update

Alakhova, D. Y., & Kabanov, A. V. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500298q · Cited by 224 · see citing works

Estimation of a significance threshold for epigenome-wide association studies

Saffari, A., Silver, M. J., Zavattari, P., Moi, L., Columbano, A., Meaburn, E. L., & Dudbridge, F. (2018) · Genetic Epidemiology · doi:10.1002/gepi.22086 · Cited by 183 · see citing works

Pan-cancer analysis identifies tumor-specific antigens derived from transposable elements

Shah, N. M., Jang, H. J., Liang, Y., Maeng, J. H., Tzeng, S.-C., Wu, A., Basri, N. L., Qu, X., Fan, C., Li, A., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01349-3 · Cited by 175 · see citing works

The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation

Tarighat, S. S., Santhanam, R., Frankhouser, D., Radomska, H. S., Lai, H., Anghelina, M., Wang, H., Huang, X., Alinari, L., Walker, A., et al. (2016) · Leukemia · doi:10.1038/leu.2015.308 · Cited by 169 · see citing works

Maternal nutritional status, C₁metabolism and offspring DNA methylation: a review of current evidence in human subjects

Dominguez-Salas, P., Cox, S. E., Prentice, A. M., Hennig, B. J., & Moore, S. E. (2012) · Proceedings of the Nutrition Society · doi:10.1017/s0029665111003338 · Cited by 163 · see citing works

Paternal grandfather’s access to food predicts all-cause and cancer mortality in grandsons

Vågerö, D., Pinger, P. R., Aronsson, V., & van den Berg, G. J. (2018) · Nature Communications · doi:10.1038/s41467-018-07617-9 · Cited by 150 · see citing works

Epigenetic modifications: Key players in cancer heterogeneity and drug resistance

Sadida, H. Q., Abdulla, A., Marzooqi, S. A., Hashem, S., Macha, M. A., Akil, A. S. A.-S., & Bhat, A. A. (2024) · Translational Oncology · doi:10.1016/j.tranon.2023.101821 · Cited by 151 · see citing works

Interplay between Epigenetics and Genetics in Cancer

Choi, J. D., & Lee, J.-S. (2013) · Genomics & Informatics · doi:10.5808/gi.2013.11.4.164 · Cited by 131 · see citing works

Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance

Sharma, S., De Carvalho, D. D., Jeong, S., Jones, P. A., & Liang, G. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001286 · Cited by 119 · see citing works

Iron addiction with ferroptosis-resistance in asbestos-induced mesothelial carcinogenesis: Toward the era of mesothelioma prevention

Toyokuni, S. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.401 · Cited by 102 · see citing works

Vitamin C – A new player in regulation of the cancer epigenome

Gillberg, L., Ørskov, A. D., Liu, M., Harsløf, L. B. S., Jones, P. A., & Grønbæk, K. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.11.001 · Cited by 100 · see citing works

Microbiota impact on the epigenetic regulation of colorectal cancer

Yang, T., Owen, J. L., Lightfoot, Y. L., Kladde, M. P., & Mohamadzadeh, M. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.08.005 · Cited by 90 · see citing works

Interactions between epigenetics and metabolism in cancers

Yun, J., Johnson, J. L., Hanigan, C. L., & Locasale, J. W. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00163 · Cited by 82 · see citing works

DNA hypomethylation of inflammation-associated genes in adipose tissue of female mice after multigenerational high fat diet feeding

Ding, Y., Li, J., Liu, S., Zhang, L., Xiao, H., Li, J., Chen, H., Petersen, R. B., Huang, K., & Zheng, L. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.98 · Cited by 76 · see citing works

Epigenetic regulation of somatostatin and somatostatin receptors in neuroendocrine tumors and other types of cancer.

Klomp, M. J., Dalm, S. U., de Jong, M., Feelders, R. A., Hofland, J., & Hofland, L. J. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09607-z · Cited by 69 · see citing works

Methylation-Based Therapies for Colorectal Cancer

Cervena, K., Siskova, A., Buchler, T., Vodicka, P., & Vymetalkova, V. (2020) · Cells · doi:10.3390/cells9061540 · Cited by 57 · see citing works

Recent insights into<i>Histone Acetyltransferase-1</i>: biological function and involvement in pathogenesis

Poziello, A., Nebbioso, A., Stunnenberg, H. G., Martens, J. H. A., Carafa, V., & Altucci, L. (2021) · Epigenetics · doi:10.1080/15592294.2020.1827723 · Cited by 44 · see citing works

Synthesis, biological evaluation, and molecular docking analysis of novel linker-less benzamide based potent and selective HDAC3 inhibitors

Routholla, G., Pulya, S., Patel, T., Abdul Amin, S., Adhikari, N., Biswas, S., Jha, T., & Ghosh, B. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105050 · Cited by 39 · see citing works

Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single‐cell resolution

Chambliss, A. B., Wu, P., Chen, W., Sun, S. X., & Wirtz, D. (2013) · The FASEB Journal · doi:10.1096/fj.12-227108 · Cited by 34 · see citing works

Epigenetic Reprogramming Associated with Primordial Germ Cell Development

Seki, Y. (2010) · Epigenetics and human health · doi:10.1007/978-3-642-14773-9_5 · Cited by 2 · see citing works

Epigenetic Inhibitors

Verma, M., & Banerjee, H. N. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1804-1_24 · Cited by 15 · see citing works

Epigenetic inhibitors and their role in cancer therapy

Abdelaziz, N., Therachiyil, L., Sadida, H. Q., Ali, A. M., Khan, O. S., Singh, M. K., Khan, A. Q., Akil, A. S. A.-S., Bhat, A. A., & Shahab Uddin, M. S. (2023) · International review of cytology · doi:10.1016/bs.ircmb.2023.04.005 · Cited by 8 · see citing works

Epigenetically Active Drugs Inhibiting DNA Methylation and Histone Deacetylation

Chistiakov, D. A., Myasoedova, V. A., Orekhov, A. N., et al. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666161021110827 · Cited by 24 · see citing works

Epigenetic therapy of cancer

Stankov, K., Pavlović, N., & Mikov, M. (2014) · Hospital Pharmacology - International Multidisciplinary Journal · doi:10.5937/hpimj1402083s · Cited by 8 · see citing works