The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
5-HT 4(a) Receptors Avert Opioid-Induced Breathing Depression Without Loss of Analgesia
Abstract
Opiates are widely used analgesics in anesthesiology, but they have serious adverse effects such as depression of breathing. This is caused by direct inhibition of rhythm-generating respiratory neurons in the Pre-Boetzinger complex (PBC) of the brainstem. We report that serotonin 4(a) [5-HT 4( a ) ] receptors are strongly expressed in respiratory PBCneurons and that their selective activation protects spontaneous respiratory activity. Treatment of rats with a 5-HT 4 receptor–specific agonist overcame fentanyl-induced respiratory depression and reestablished stable respiratory rhythm without loss of fentanyl's analgesic effect. These findings imply the prospect of a fine-tuned recovery from opioid-induced respiratory depression, through adjustment of intracellular adenosine 3′,5′-monophosphate levels through the convergent signaling pathways in neurons.
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Cites
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Cited by
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Respiratory control by ventral surface chemoreceptor neurons in rats
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Understanding the Rhythm of Breathing: So Near, Yet So Far
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Brainstem respiratory networks: building blocks and microcircuits
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Metadata
- Authors
- Manzke, T., Guenther, U., Ponimaskin, E. G., Haller, M., Dutschmann, M., Schwarzacher, S., & Richter, D. W.
- Venue
- Science
- Published
- 2003-07-11
- Volume
- 301
- Issue
- 5630
- Pages
- 226-229
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2022131604
- Cited by
- 276
- References
- 16
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Manzke, T., Guenther, U., Ponimaskin, E. G., Haller, M., Dutschmann, M., Schwarzacher, S., & Richter, D. W. (2003). 5-HT 4(a) Receptors Avert Opioid-Induced Breathing Depression Without Loss of Analgesia. Science. https://doi.org/10.1126/science.1084674
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