The expanded biology of serotonin

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works

Valvular heart disease associated with fenfluramine-phentermine

Connolly, H. M., Crary, J. L., McGoon, M. D., Hensrud, D. D., Edwards, B. S., Edwards, W. D., & Schaff, H. V. (1997) · New England Journal of Medicine · doi:10.1056/nejm199708283370901 · Cited by 1,632 · see citing works

The serotonin signaling system: from basic understanding to drug development for functional GI disorders

Gershon, M. D., & Tack, J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.002 · Cited by 1,563 · see citing works

Long story short: the serotonin transporter in emotion regulation and social cognition

Canli, T., & Lesch, K.-P. (2007) · Nature Neuroscience · doi:10.1038/nn1964 · Cited by 1,034 · see citing works

Neuroendocrine pharmacology of stress

Carrasco, G. A., & Van de Kar, L. D. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01285-8 · Cited by 914 · see citing works

Valvular Heart Disease and the Use of Dopamine Agonists for Parkinson's Disease

Zanettini, R., Antonini, A., Gatto, G., Gentile, R., Tesei, S., & Pezzoli, G. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa054830 · Cited by 882 · see citing works

Selective Serotonin-Reuptake Inhibitors and Risk of Persistent Pulmonary Hypertension of the Newborn

Chambers, C., Hernández–Dı́az, S., Marter, L. J. V., Werler, M. M., Louik, C., Jones, K. L., & Mitchell, A. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052744 · Cited by 877 · see citing works

Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies

Ruhé, H. G., Mason, N. S., & Schene, A. H. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001949 · Cited by 861 · see citing works

H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs

Kroeze, W. K., Hufeisen, S. J., Popadak, B. A., Renock, S. M., Steinberg, S., Ernsberger, P. R., Jayathilake, K., Meltzer, H. Y., & Roth, B. L. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300027 · Cited by 803 · see citing works

Platelet-Derived Serotonin Mediates Liver Regeneration

Lesurtel, M., Graf, R., Aleil, B., Walther, D. J., Tian, Y., Jochum, W., Gachet, C., Bäder, M., & Clavien, P. (2006) · Science · doi:10.1126/science.1123842 · Cited by 783 · see citing works

Evidence for Possible Involvement of 5-HT _2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications

Rothman, R. B., Baumann, M. H., Savage, J. E., Rauser, L., McBride, A., Hufeisen, S. J., & Roth, B. L. (2000) · Circulation · doi:10.1161/01.cir.102.23.2836 · Cited by 722 · see citing works

Dopamine Agonists and the Risk of Cardiac-Valve Regurgitation

Schade, R., Andersohn, F., Suissa, S., Haverkamp, W., & Garbe, E. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa062222 · Cited by 714 · see citing works

5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex

Araneda, R. C., & Andrade, R. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90128-b · Cited by 621 · see citing works

The developmental origins of anxiety

Gross, C. T., & Hen, R. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1429 · Cited by 563 · see citing works

SERUM VASOCONSTRICTOR (SEROTONIN)

Rapport, M. M., Green, A. A., & Page, I. H. (1948) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)57137-4 · Cited by 552 · see citing works

Effects of Antidepressant Medication on Morbidity and Mortality in Depressed Patients After Myocardial Infarction

Taylor, C. B. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.7.792 · Cited by 512 · see citing works

Multiple Serotonergic Brainstem Abnormalities in Sudden Infant Death Syndrome

Paterson, D. S., Trachtenberg, F. L., Thompson, E. G., Belliveau, R. A., Beggs, A. H., Darnall, R., Chadwick, A. E., Krous, H. F., & Kinney, H. C. (2006) · JAMA · doi:10.1001/jama.296.17.2124 · Cited by 503 · see citing works

Drugs and Valvular Heart Disease

Roth, B. L. (2007) · New England Journal of Medicine · doi:10.1056/nejmp068265 · Cited by 479 · cited 4× · see citing works

Serotonylation of small GTPases is a signal transduction pathway that triggers platelet α-granule release

Walther, D. J., Peter, J.-U., Winter, S., Höltje, M., Paulmann, N., Grohmann, M., Vowinckel, J., Alamo-Bethencourt, V., Wilhelm, C. S., Ahnert-Hilger, G., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)01014-6 · Cited by 475 · see citing works

Possible Role of Valvular Serotonin 5-HT2B Receptors in the Cardiopathy Associated with Fenfluramine

Fitzgerald, L. W., Burn, T. C., Brown, B. S., Patterson, J. P., Corjay, M. H., Valentine, P. A., Sun, J., Link, J. R., Abbaszade, I. G., Hollis, J. M., et al. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)26444-0 · Cited by 440 · see citing works

Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension

Launay, J., Hervé, P., Peoc’h, K., Tournois, C., Callebert, J., Nebigil, C. G., Étienne-Selloum, N., Drouet, L. O., Humbert, M. J. C., Simonneau, G., et al. (2002) · Nature Medicine · doi:10.1038/nm764 · Cited by 433 · see citing works

High-speed imaging reveals neurophysiological links to behavior in an animal model of depression

Airan, R. D., Meltzer, L. A., Roy, M., Gong, Y., Chen, H., & Deisseroth, K. (2007) · Science · doi:10.1126/science.1144400 · Cited by 396 · see citing works

Serotonin and Migraine: Biology and Clinical Implications

Hamel, É., & Currents, H. (2007) · Cephalalgia · doi:10.1111/j.1468-2982.2007.01476.x · Cited by 335 · see citing works

Defects in Breathing and Thermoregulation in Mice with Near-Complete Absence of Central Serotonin Neurons

Hodges, M. R., Tattersall, G. J., Harris, M. B., McEvoy, S. D., Richerson, D. N., Deneris, E. S., Johnson, R. L., Chen, Z., & Richerson, G. B. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4729-07.2008 · Cited by 320 · see citing works

3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) Induces Fenfluramine-Like Proliferative Actions on Human Cardiac Valvular Interstitial Cells in Vitro

Setola, V., Hufeisen, S. J., Grande-Allen, K. J., Veselý, I., Glennon, R. A., Blough, B. E., Rothman, R. B., & Roth, B. L. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.6.1223 · Cited by 305 · see citing works

5-Hydroxytryptamine receptors in the human cardiovascular system

Kaumann, A. J., & Levy, F. O. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.12.004 · Cited by 304 · see citing works

Molecular Biology of Serotonin Receptors - Structure and Function at the Molecular Level

Kroeze, W. K., Kristiansen, K., & Roth, B. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023393796 · Cited by 278 · see citing works

5-HT 4(a) Receptors Avert Opioid-Induced Breathing Depression Without Loss of Analgesia

Manzke, T., Guenther, U., Ponimaskin, E. G., Haller, M., Dutschmann, M., Schwarzacher, S. W., & Richter, D. W. (2003) · Science · doi:10.1126/science.1084674 · Cited by 277 · see citing works

Serotonin 5-HT2C Receptor Agonist Promotes Hypophagia via Downstream Activation of Melanocortin 4 Receptors

Lam, D. D., Przydzial, M. J., Ridley, S. H., Yeo, G. S. H., Rochford, J. J., O’Rahilly, S., & Heisler, L. K. (2007) · Endocrinology · doi:10.1210/en.2007-1321 · Cited by 270 · see citing works

REVIEW ARTICLE: Coated-platelets: an emerging component of the procoagulant response

Dale, G. L. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01274.x · Cited by 266 · see citing works

Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders

Roth, B., Hanizavareh, S. M., & Blum, A. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1683-8 · Cited by 259 · see citing works

Serotonin in Pain and Analgesia: Actions in the Periphery

Sommer, C. (2004) · Molecular Neurobiology · doi:10.1385/mn:30:2:117 · Cited by 256 · see citing works

Serotonin Regulates Mammary Gland Development via an Autocrine-Paracrine Loop

Matsuda, M., Imaoka, T., Vomachka, A. J., Gudelsky, G. A., Hou, Z., Mistry, M. J., Bailey, J. P., Nieport, K. M., Walther, D. J., Bäder, M., et al. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00022-x · Cited by 250 · see citing works

Effect of antidepressants and their relative affinity for the serotonin transporter on the risk of myocardial infarction

Sauer, W. H., Berlin, J. A., & Kimmel, S. E. (2003) · Circulation · doi:10.1161/01.cir.0000079172.43229.cd · Cited by 247 · see citing works

Medullary Serotonergic Network Deficiency in the Sudden Infant Death Syndrome: Review of a 15-Year Study of a Single Dataset

Kinney, H. C., Filiano, J. J., & White, W. F. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.3.228 · Cited by 231 · see citing works

Serotonin toxicity: a practical approach to diagnosis and treatment

Isbister, G. K., Buckley, N. A., & Whyte, I. M. (2007) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2007.tb01282.x · Cited by 231 · see citing works

Innovative approaches for the development of antidepressant drugs: Current and future strategies

Schechter, L. E., Ring, R. H., Beyer, C. E., Hughes, Z. A., Khawaja, X. Z., Malberg, J. E., & Rosenzweig-Lipson, S. J. (2005) · NeuroRx · doi:10.1602/neurorx.2.4.590 · Cited by 229 · see citing works

SERUM VASOCONSTRICTOR (SEROTONIN)

Rapport, M. M., Green, A. A., & Page, I. H. (1948) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)57136-2 · Cited by 225 · see citing works

A double-blind clinical trial in weight control. Use of fenfluramine and phentermine alone and in combination

Weintraub, M. (1984) · Archives of Internal Medicine · doi:10.1001/archinte.144.6.1143 · Cited by 217 · see citing works

Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery

O'Connor, K. A., & Roth, B. L. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1900 · Cited by 215 · see citing works

Multiple Serotonin Receptors: Clinical and Experimental Aspects

Roth, B. L. (1994) · Annals of Clinical Psychiatry · doi:10.3109/10401239409148985 · Cited by 213 · see citing works

Serotonin Transporter Inhibitors Protect against Hypoxic Pulmonary Hypertension

Marcos, É., Adnot, S., Pham, M. H., Nosjean, A., Raffestin, B., Hamon, M., & Eddahibi, S. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200210-1212oc · Cited by 203 · see citing works

8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents

Hedlund, P. B., Kelly, L., Mazur, C., Lovenberg, T. W., Sutcliffe, J. G., & Bonaventure, P. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.01.031 · Cited by 192 · see citing works

5‐HYDROXYTRYPTAMINE IN THE CARDIOVASCULAR SYSTEM: FOCUS ON THE SEROTONIN TRANSPORTER (SERT)

Ni, W., & Watts, S. W. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04410.x · Cited by 189 · see citing works

Serotonin and the Orchestration of Energy Balance

Tecott, L. H. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.012 · Cited by 188 · see citing works

The pipeline and future of drug development in schizophrenia

Gray, J. A., & Roth, B. L. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002062 · Cited by 181 · see citing works

Interactions between integrin αIIbβ3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans

Carneiro, A. M. D., Cook, E. H., Murphy, D. L., & Blakely, R. D. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33374 · Cited by 180 · see citing works

Contributions of 5-HT2C receptors to multiple actions of central serotonin systems

Giorgetti, M., & Tecott, L. H. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.01.036 · Cited by 173 · see citing works

Antidepressant Agents for the Treatment of Chronic Pain and Depression

Jann, M. W., & Slade, J. H. (2007) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.27.11.1571 · Cited by 172 · see citing works

Chemosensitivity of serotonergic neurons in the rostral ventral medulla

Richerson, G. B., Wang, W., Tiwari, J., & Bradley, S. R. (2001) · Respiration Physiology · doi:10.1016/s0034-5687(01)00289-4 · Cited by 163 · see citing works

High Plasma Serotonin Levels in Primary Pulmonary Hypertension

Kéreveur, A., Callebert, J., Humbert, M. J. C., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.10.2233 · Cited by 142 · see citing works

Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes

Lam, D. D., & Heisler, L. K. (2007) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399407000245 · Cited by 142 · see citing works

Mammary gland homeostasis employs serotonergic regulation of epithelial tight junctions

Stull, M. A., Pai, V. P., Vomachka, A. J., Marshall, A. M., Jacob, G. A., & Horseman, N. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708136104 · Cited by 139 · see citing works

The role of central 5‐hydroxytryptamine (5‐HT, serotonin) receptors in the control of micturition

Ramage, A. G. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706504 · Cited by 127 · see citing works

Pharmacological aspects of anticancer drug-induced emesis with emphasis on serotonin release and vagal nerve activity

Minami, M., Endo, T., Hirafuji, M., Hamaue, N., Liu, Y., Hiroshige, T., Nemoto, M., Saito, H., & Yoshioka, M. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00057-3 · Cited by 124 · see citing works

5-hydroxytryptamine in premature ejaculation: opportunities for therapeutic intervention

Giuliano, F. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.12.002 · Cited by 122 · see citing works

Signaling in the Chemosensory Systems

Roper, S. D. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6112-9 · Cited by 119 · see citing works

Transglutaminase-dependent RhoA Activation and Depletion by Serotonin in Vascular Smooth Muscle Cells

Guilluy, C., Rolli‐Derkinderen, M., Tharaux, P., Melino, G., Pacaud, P., & Loirand, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604195200 · Cited by 117 · see citing works

Possible Association Between 3,4-Methylenedioxymethamphetamine Abuse and Valvular Heart Disease

Droogmans, S., Cosyns, B., D’Haenen, H., Creeten, E., Weytjens, C., Franken, P. R., Scott, B., Schoors, D. F., Kemdem, A., Close, L., et al. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.06.045 · Cited by 106 · see citing works

The serotonin receptors : from molecular pharmacology to human therapeutics

Roth, B. L. (2006) · Cited by 102 · see citing works

Serotonin and the neurobiology of the ejaculatory threshold.

de Jong, T. D., Veening, J., Waldinger, M., Cools, A., & Olivier, B. (2006) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.01.001 · Cited by 99 · see citing works

Arrest of 5HT neuron differentiation delays respiratory maturation and impairs neonatal homeostatic responses to environmental challenges

Erickson, J. T., Shafer, G. O., Rossetti, M. D., Wilson, C. G., & Deneris, E. S. (2007) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2007.06.002 · Cited by 97 · see citing works

Pathophysiology of preeclampsia and the role of serotonin

Bolte, A. C., van Geijn, H. P., & Dekker, G. (2001) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00367-5 · Cited by 92 · see citing works

Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure

Brattelid, T., Qvigstad, E., Lynham, J. A., Molenaar, P., Aass, H., Geiran, O. R., Skomedal, T., Osnes, J. B., Levy, F. O., & Kaumann, A. (2004) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-004-0963-0 · Cited by 77 · see citing works

The Risk of Postpartum Hemorrhage With Selective Serotonin Reuptake Inhibitors and Other Antidepressants

Salkeld, E., Ferris, L. E., & Juurlink, D. N. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318166c52e · Cited by 71 · see citing works

Functional Consequence of Serotonin/5-HT 2B Receptor Signaling in Heart

Nebigil, C. G., & Maroteaux, L. (2003) · Circulation · doi:10.1161/01.cir.0000081520.25714.d9 · Cited by 65 · see citing works

Genetically expressed transneuronal tracer reveals direct and indirect serotonergic descending control circuits

Braz, J. M., & Basbaum, A. I. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21665 · Cited by 61 · see citing works

The role of 5-HT on the cardiovascular and renal systems and the clinical potential of 5-HT modulation

Doggrell, S. A. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.5.805 · Cited by 61 · see citing works

5-hydroxytryptamine strongly inhibits fluid secretion in guinea pig pancreatic duct cells

Suzuki, A., Naruse, S., Kitagawa, M., Ishiguro, H., Yoshikawa, T., Ko, S. B. H., Yamamoto, A., Hamada, H., & Hayakawa, T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12312 · Cited by 58 · see citing works

Activity of the Serotonergic System During Isoflurane Anesthesia

Mukaida, K., Shichino, T., Koyanagi, S., Himukashi, S., & Fukuda, K. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000255200.42574.22 · Cited by 53 · see citing works

Serotonin: An inducer of collagenase in myometrial smooth muscle cells

Jeffrey, J. J., Ehlich, L. S., & Roswit, W. T. (1991) · Journal of Cellular Physiology · doi:10.1002/jcp.1041460310 · Cited by 53 · see citing works

Functions of serotonin in hypoxic pulmonary vascular remodeling

Esteve, J. M., Launay, J., Kellermann, O., & Maroteaux, L. (2007) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:47:1:33 · Cited by 48 · see citing works

Depression and Heart Disease: Therapeutic Implications

Somberg, T., & Arora, R. R. (2008) · Cardiology · doi:10.1159/000119692 · Cited by 47 · see citing works

Effects of treatment with a 5‐HT4receptor antagonist in heart failure

Birkeland, J. A. K., Sjaastad, I., Brattelid, T., et al. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706966 · Cited by 43 · see citing works

Functional reactivity of 5-HT receptors in human umbilical cord and maternal subcutaneous fat arteries after normotensive or pre-eclamptic pregnancy

Gupta, S., Hanff, L. M., Visser, W. E., et al. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000234115.40648.88 · Cited by 38 · see citing works

The Natural Mutation Encoding a C Terminus-Truncated 5-Hydroxytryptamine2B Receptor Is a Gain of Proliferative Functions

Deraët, M., Manivet, P., Janoshazi, A. K., et al. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.008268 · Cited by 35 · see citing works

Mouse Genetic Approaches to Feeding Regulation: Serotonin 5-HT2CReceptor Mutant Mice

Tecott, L. H., & Abdallah, L. (2003) · CNS Spectrums · doi:10.1017/s109285290001885x · Cited by 34 · see citing works

Chemical Neuroanatomy of 5-HT Receptor Subtypes in the Mammalian Brain

Mengod, G., Vilaró, M. T., Cortés, R., López-Giménez, J. F., Raurich, A., & Palacios, J. M. (2006) · The Receptors · doi:10.1007/978-1-59745-080-5_10 · Cited by 33 · see citing works

Serotonergic gene inactivation in mice: models for anxiety and aggression?

Lesch, K. (2005) · Novartis Foundation symposium · doi:10.1002/0470010703.ch9 · Cited by 31 · see citing works

Molecular and Cellular Mechanisms for the Polarized Sorting of Serotonin Receptors: Relevance for Genesis and Treatment of Psychosis

Roth, B. L., & Xia, Z. (2004) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v16.i4.10 · Cited by 31 · see citing works

Does Treating Post–Myocardial Infarction Depression Reduce Medical Mortality?

Glassman, A. H. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.7.711 · Cited by 31 · see citing works

Atrial fibrillation in carcinoid heart disease

Langer, C., Piper, C., Vogt, J., Heintze, J., Butz, T., Lindner, O., Burchert, W., Kersting, C., & Horstkotte, D. (2006) · Clinical Research in Cardiology · doi:10.1007/s00392-006-0463-y · Cited by 26 · see citing works

Increased 5‐HT contractile response in late pregnant rat myometrium is associated with a higher density of 5‐HT2A receptors

Minosyan, T. Y., Lü, R., Eghbali, M., et al. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.129726 · Cited by 24 · see citing works

Trials of New Antiarrhythmic Drugs for Maintenance of Sinus Rhythm in Patients with Atrial Fibrillation

Singh, S. N. (2004) · Journal of Interventional Cardiac Electrophysiology · doi:10.1023/b:jice.0000011348.05608.e5 · Cited by 17 · see citing works

Opioid-induced Respiratory Depression: Are 5-HT4a Receptor Agonists the Cure?

Eilers, H. (2004) · Molecular Interventions · doi:10.1124/mi.4.4.3 · Cited by 12 · see citing works

The ovarian and cervical regions of the rat uterus display a different contractile response to serotonin and prostaglandin F2α I. The estrous cycle

Oropeza, M. V., Monter, H. A. P., Isla, M. R., et al. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)80010-7 · Cited by 11 · see citing works

The treatment of urinary incontinence with Duloxetine

Basu, M., & Duckett, J. (2008) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443610801912931 · Cited by 10 · see citing works

5-hydroxytryptamine strongly inhibits fluid secretion in guinea pig pancreatic duct cells

Suzuki, A., Naruse, S., Kitagawa, M., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112312 · Cited by 7 · see citing works

Can SSRIs reduce the risk of preeclampsia in pregnant, depressed patients?

Dawes, S. D. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.10.038 · Cited by 5 · see citing works

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works

Neurotransmitter modulation by the gut microbiota

Strandwitz, P. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.015 · Cited by 1,527 · see citing works

Minireview: Gut microbiota: The neglected endocrine organ

Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192 · see citing works

Serotonin signalling in the gut: functions, dysfunctions and therapeutic targets

Mawe, G. M., & Hoffman, J. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.105 · Cited by 1,165 · see citing works

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110 · see citing works

Control of brain development, function, and behavior by the microbiome

Sampson, T. R., & Mazmanian, S. K. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.011 · Cited by 1,093 · see citing works

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.50 · Cited by 969 · see citing works

Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis

Jenkins, T., Nguyen, J., Polglaze, K., & Bertrand, P. (2016) · Nutrients · doi:10.3390/nu8010056 · Cited by 904 · see citing works

Kynurenine pathway metabolism and the microbiota-gut-brain axis

Kennedy, P. J., Cryan, J. F., Dinan, T. G., & Clarke, G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.002 · Cited by 724 · see citing works

Growing up in a bubble: using germ-free animals to assess the influence of the gut microbiota on brain and behavior

Luczynski, P., McVey Neufeld, K.-A., Oriach, C. S., Clarke, G., Dinan, T. G., & Cryan, J. F. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw020 · Cited by 632 · see citing works

Pathophysiology of irritable bowel syndrome

Holtmann, G. J., Ford, A. C., & Talley, N. J. (2016) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(16)30023-1 · Cited by 590 · see citing works

Specialized metabolites from the microbiome in health and disease

Sharon, G., Garg, N., Debelius, J., Knight, R., Dorrestein, P. C., & Mazmanian, S. K. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.016 · Cited by 544 · see citing works

The effects of serotonin in immune cells

Herr, N., Bode, C., & Duerschmied, D. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00048 · Cited by 497 · see citing works

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works

Metabolomic Analysis of Livers and Serum from High-Fat Diet Induced Obese Mice

Kim, H.-J., Kim, J. H., Noh, S., Hur, H. J., Sung, M. J., Hwang, J.-T., Park, J. H., Yang, H. J., Kim, M.-S., Kwon, D. Y., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr100892r · Cited by 376 · see citing works

Structure-based discovery of nonhallucinogenic psychedelic analogs

Cao, D., Yu, J., Wang, H., Luo, Z., Liu, X., He, L., Qi, J., Fan, L., Tang, L., Chen, Z., et al. (2022) · Science · doi:10.1126/science.abl8615 · Cited by 312 · see citing works

Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior

Gacias, M., Gaspari, S., Santos, P.-M. G., Tamburini, S., Andrade, M., Zhang, F., Shen, N., Tolstikov, V., Kiebish, M. A., Dupree, J. L., et al. (2016) · eLife · doi:10.7554/elife.13442 · Cited by 308 · see citing works

Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma

Jiang, S., Postovit, L., Cattaneo, A., Binder, E. B., & Aitchison, K. J. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00808 · Cited by 288 · see citing works

Non-conventional features of peripheral serotonin signalling — the gut and beyond

Spohn, S. N., & Mawe, G. M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.51 · Cited by 282 · see citing works

Cross talk: the microbiota and neurodevelopmental disorders

Kelly, J. R., Minuto, C., Cryan, J. F., Clarke, G., & Dinan, T. G. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00490 · Cited by 271 · see citing works

Microbiome, inflammation, epigenetic alterations, and mental diseases

Alam, R., Abdolmaleky, H. M., & Zhou, J. (2017) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32567 · Cited by 240 · see citing works

β-cell adaptation in pregnancy

Baeyens, L., Hindi, S., Sorenson, R. L., & German, M. S. (2016) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12716 · Cited by 210 · see citing works

Gastrointestinal issues in autism spectrum disorder

Hsiao, E. Y. (2014) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000029 · Cited by 209 · see citing works

Effects of Selective Serotonin Reuptake Inhibitors on Platelet Function: Mechanisms, Clinical Outcomes and Implications for Use in Elderly Patients

de Abajo, F. J. (2011) · Drugs & Aging · doi:10.2165/11589340-000000000-00000 · Cited by 206 · see citing works

The serotonergic system in Parkinson's disease

Huot, P., Fox, S. H., & Brotchie, J. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.004 · Cited by 195 · see citing works

Characterizing the interplay between autism spectrum disorder and comorbid medical conditions: an integrative review

Tye, C., Runicles, A. K., Whitehouse, A. J. O., & Alvares, G. A. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00751 · Cited by 177 · see citing works

Role of microbiota and tryptophan metabolites in the remote effect of intestinal inflammation on brain and depression

Waclawiková, B., & El Aidy, S. (2018) · Pharmaceuticals · doi:10.3390/ph11030063 · Cited by 172 · see citing works

<p>Gut Microbiota Regulates Depression-Like Behavior in Rats Through the Neuroendocrine-Immune-Mitochondrial Pathway</p>

Liu, S., Guo, R., Liu, F., Yuan, Q., Yu, Y., & Ren, F. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s243551 · Cited by 130 · see citing works

The role of the microbiome in the neurobiology of social behaviour

Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135 · see citing works

The developmental disruptions of serotonin signaling may involved in autism during early brain development

Yang, C.-J., Tan, H.-P., & Du, Y.-J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.02.021 · Cited by 132 · see citing works

Primum Non Nocere: An Evolutionary Analysis of Whether Antidepressants Do More Harm than Good

Andrews, P. W., Thomson, J. A., Amstadter, A., & Neale, M. C. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00117 · Cited by 120 · see citing works

A descriptive review on the prevalence of gastrointestinal disturbances and their multiple associations in autism spectrum disorder

Lefter, R., Ciobica, A., Timofte, D., Stanciu, C., & Trifan, A. (2019) · Medicina · doi:10.3390/medicina56010011 · Cited by 120 · see citing works

Affective neuroscientific and neuropsychoanalytic approaches to two intractable psychiatric problems: Why depression feels so bad and what addicts really want

Zellner, M. R., Watt, D. F., Solms, M., & Panksepp, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.01.003 · Cited by 112 · see citing works

HPLC-PDA-MS/MS profiling of secondary metabolites from Opuntia ficus-indica cladode, peel and fruit pulp extracts and their antioxidant, neuroprotective effect in rats with aluminum chloride induced neurotoxicity

El-Hawary, S. S., Sobeh, M., Badr, W. K., Abdelfattah, M. A. O., Ali, Z. Y., El-Tantawy, M. E., Rabeh, M. A., & Wink, M. (2020) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.07.003 · Cited by 102 · see citing works

Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway

Fang, Y., Ding, X., Zhang, Y., Cai, L., Ge, Y., Ma, K., Xu, R., Li, S., Song, M., Zhu, H., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02389-y · Cited by 96 · see citing works

Psychedelics, Sociality, and Human Evolution

Rodríguez Arce, J. M., & Winkelman, M. J. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.729425 · Cited by 86 · see citing works

Antidepressant and anxiolytic effects of activating 5HT2A receptors in the anterior cingulate cortex and the theoretical mechanisms underlying them – A scoping review of available literature

Miranda, L. (2025) · Brain Research · doi:10.1016/j.brainres.2024.149226 · Cited by 66 · see citing works

A novel serotonin-secreting cell type regulates ciliary motility in the mucociliary epidermis of <i>Xenopus</i> tadpoles

Walentek, P., Bogusch, S., Thumberger, T., Vick, P., Dubaissi, E., Beyer, T., Blum, M., & Schweickert, A. (2014) · Development · doi:10.1242/dev.102343 · Cited by 61 · see citing works

Gut Microbiota: A Pivotal Hub for Polyphenols as Antidepressants

Zhou, N., Gu, X., Zhuang, T., Xu, Y., Yang, L., & Zhou, M. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c01461 · Cited by 54 · see citing works

Interaction mechanisms between major depressive disorder and non-alcoholic fatty liver disease

Shao, Q., Wu, Y., Ji, J., Xu, T., Yu, Q., Ma, C., Liao, X., Cheng, F., & Wang, X. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.711835 · Cited by 32 · see citing works

On the possible quantum role of serotonin in consciousness

Tonello, L., Cocchi, M., Gabrielli, F., & Tuszynski, J. A. (2015) · Journal of Integrative Neuroscience · doi:10.1142/s021963521550017x · Cited by 31 · see citing works

Lipidomic profiling of tryptophan hydroxylase 2 knockout mice reveals novel lipid biomarkers associated with serotonin deficiency

Weng, R., Shen, S., Burton, C., Yang, L., Nie, H., Tian, Y., Bai, Y., & Liu, H. (2016) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-9256-3 · Cited by 31 · see citing works

DNA Hypermethylation of the Serotonin Receptor Type-2A Gene Is Associated with a Worse Response to a Weight Loss Intervention in Subjects with Metabolic Syndrome

Perez-Cornago, A., Mansego, M., Zulet, M., & Martinez, J. (2014) · Nutrients · doi:10.3390/nu6062387 · Cited by 28 · see citing works

HTS and Rational Drug Design to Generate a Class of 5‐HT_2C‐Selective Ligands for Possible Use in Schizophrenia.

Kozikowski, A. P., Cho, S. J., Jensen, N. H., Allen, J. A., Svennebring, A. M., & Roth, B. L. (2010) · ChemMedChem · doi:10.1002/cmdc.201000186 · Cited by 28 · see citing works

Serotonin as a Putative Scavenger of Hypohalous Acid in the Brain

Kalogiannis, M., Delikatny, E. J., & Jeitner, T. M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.012 · Cited by 19 · see citing works

Study on the comorbid mechanisms of sarcopenia and late-life depression

Wu, J., Tang, J., Huang, D., Wang, Y., Zhou, E., Ru, Q., Xu, G., Chen, L., & Wu, Y. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115538 · Cited by 12 · see citing works

Neurological mechanism-based analysis of the role and characteristics of physical activity in the improvement of depressive symptoms

Wang, N., Zhu, S., Chen, S., Zou, J., Zeng, P., & Tan, S. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0147 · Cited by 12 · see citing works

Early-life adversity severity, timing, and context type are associated with SLC6A4 methylation in emerging adults: results from a prospective cohort study

Koning, S. M., Kessler, C. L., Canli, T., Duman, E. A., Adam, E. K., Zinbarg, R., Craske, M. G., Stephens, J. E., & Vrshek-Schallhorn, S. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107181 · Cited by 8 · see citing works

5-HT2A, 5-HT1B/D, 5HT3 and 5-HT7 receptors as mediators of serotonin-induced direct contractile response of bovine airway smooth muscle

Guevara, D. D. C., & Trejo, E. J. (2021) · Journal of Smooth Muscle Research · doi:10.1540/jsmr.57.79 · Cited by 3 · see citing works

Central serotonergic receptors: Evidence for heterogeneity and characterization by ligand-binding

Nelson, D. L. (1982) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(82)90031-8 · Cited by 17 · see citing works

[Serotonin and cardiovascular control].

Aurup, P., & Højberg, S. (1990) · PubMed · Cited by 1 · see citing works

Serotonin and Enteric Nervous System-A Minireview

Yu, P.-L. (2009) · Adaptive Medicine · doi:10.4247/am.2009.aam005

Studies on the Localization of Serotonergic Neurones and the Types of Serotonin Receptors in the Mammalian Retina

Osborne, N. N., Barnett, N. L., Ghazi, H. O., et al. (1989) · Springer eBooks · doi:10.1007/978-3-642-74149-4_3 · Cited by 3 · see citing works