The DOI matches its Crossref record.
Sex-Dependent Gene Expression and Evolution of the Drosophila Transcriptome
Abstract
Comparison of the gene-expression profiles between adults of Drosophila melanogaster and Drosophila simulans has uncovered the evolution of genes that exhibit sex-dependent regulation. Approximately half the genes showed differences in expression between the species, and among these, ∼83% involved a gain, loss, increase, decrease, or reversal of sex-biased expression. Most of the interspecific differences in messenger RNA abundance affect male-biased genes. Genes that differ in expression between the species showed functional clustering only if they were sex-biased. Our results suggest that sex-dependent selection may drive changes in expression of many of the most rapidly evolving genes in the Drosophila transcriptome.
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Cited by
The origin of new genes: Glimpses from the young and old
Long, M., Betrán, E., Thornton, K., & Wang, W. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1204 · Cited by 933
The evolution of sex-biased genes and sex-biased gene expression
Ellegren, H., & Parsch, J. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2167 · Cited by 925
Evolutionary changes in cis and trans gene regulation
Wittkopp, P. J., Haerum, B. K., & Clark, A. G. (2004) · Nature · doi:10.1038/nature02698 · Cited by 873
Sex-specific genetic architecture of human disease
Ober, C., Loisel, D. A., & Gilad, Y. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2415 · Cited by 787
Genomewide Nonadditive Gene Regulation in Arabidopsis Allotetraploids
Wang, J., Tian, L., Lee, H.-S., Wei, N. E., Jiang, H., Watson, B., Madlung, A., Osborn, T. C., Doerge, R. W., Comai, L., et al. (2006) · Genetics · doi:10.1534/genetics.105.047894 · Cited by 599
Metadata
- Authors
- Ranz, J. M., Castillo-Davis, C. I., Meiklejohn, C. D., & Hartl, D. L.
- Venue
- Science
- Published
- 2003-06-13
- Volume
- 300
- Issue
- 5626
- Pages
- 1742-1745
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2131160279
- Cited by
- 617
- References
- 0
- FWCI
- 21.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ranz, J. M., Castillo-Davis, C. I., Meiklejohn, C. D., & Hartl, D. L. (2003). Sex-Dependent Gene Expression and Evolution of the Drosophila Transcriptome. Science. https://doi.org/10.1126/science.1085881
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