Cited by 925Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesEvolution and Genetic DynamicsChromosomal and Genetic Variations

The evolution of sex-biased genes and sex-biased gene expression

Ellegren, Hans, Parsch, John·2007·Nature Reviews Genetics

Abstract

Differences between males and females in the optimal phenotype that is favoured by selection can be resolved by the evolution of differential gene expression in the two sexes. Microarray experiments have shown that such sex-biased gene expression is widespread across organisms and genomes. Sex-biased genes show unusually rapid sequence evolution, are often labile in their pattern of expression, and are non-randomly distributed in the genome. Here we discuss the characteristics and expression of sex-biased genes, and the selective forces that shape this previously unappreciated source of phenotypic diversity. Sex-biased gene expression has implications beyond just evolutionary biology, including for medical genetics.

Integrity signals

Registry

Crossref · 10.1038/nrg2167

Cites

89 of 89 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

1 of the 90 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Ellegren, H., & Parsch, J.
Affiliations
  • Uppsala University (SE)
  • Ludwig-Maximilians-Universität München (DE)
Corresponding author
  • Ellegren, Hans
  • Parsch, John
Venue
Nature Reviews Genetics
Published
2007-08-07
Volume
8
Issue
9
Pages
689-698
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2057277929
Cited by
925
References
90
Citations by year
2026: 27 · 2025: 41 · 2024: 39 · 2023: 58 · 2022: 58 · 2021: 62 · 2020: 39 · 2019: 53 · 2018: 60 · 2017: 53 · 2016: 55 · 2015: 41 · 2014: 68 · 2013: 46 · 2012: 40
FWCI
4.57
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • Vetenskapsrådet
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Keywords
sex-biased genes, sex-biased gene expression, sex differences, gene expression patterns, sexual dimorphism, phenotypic diversity, selection, medical genetics
MeSH terms
Animals, Chromosome Mapping, Codon, Female, Gene Expression Regulation, Humans, Male, Selection, Genetic, Sex Characteristics, Sex Chromosomes, Open Reading Frames, Gene Dosage, Evolution, Molecular, Genes, X-Linked, Genes, Y-Linked

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review