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Loss of a Callose Synthase Results in Salicylic Acid-Dependent Disease Resistance
Abstract
Plants attacked by pathogens rapidly deposit callose, a β-1,3-glucan, at wound sites. Traditionally, this deposition is thought to reinforce the cell wall and is regarded as a defense response. Surprisingly, here we found that powdery mildew resistant 4 ( pmr4 ), a mutant lacking pathogen-induced callose, became resistant to pathogens, rather than more susceptible. This resistance was due to mutation of a callose synthase, resulting in a loss of the induced callose response. Double-mutant analysis indicated that blocking the salicylic acid (SA) defense signaling pathway was sufficient to restore susceptibility to pmr4 mutants. Thus, callose or callose synthase negatively regulates the SA pathway.
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Cited by
Glucosinolate Metabolites Required for an Arabidopsis Innate Immune Response
Clay, N. K., Adio, A. M., Denoux, C., Jander, G., & Ausubel, F. M. (2009) · Science · doi:10.1126/science.1164627 · Cited by 1,098
Plant cell wall‐mediated immunity: cell wall changes trigger disease resistance responses
Bacete, L., Mélida, H., Miedes, E., & Molina, A. (2018) · The Plant Journal · doi:10.1111/tpj.13807 · Cited by 659
Regulation of the NADPH Oxidase RBOHD During Plant Immunity
Kadota, Y., Shirasu, K., & Zipfel, C. (2015) · Plant and Cell Physiology · doi:10.1093/pcp/pcv063 · Cited by 641
Ferrari, S. (2013) · Frontiers in Plant Science · doi:10.3389/fpls.2013.00049 · Cited by 573
The role of the cell wall in plant immunity
Malinovsky, F. G., Fangel, J. U., & Willats, W. G. T. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00178 · Cited by 555
Metadata
- Authors
- Nishimura, M. T., Stein, M., Hou, B.-H., Vogel, J. P., Edwards, H., & Somerville, S. C.
- Venue
- Science
- Published
- 2003-08-15
- Volume
- 301
- Issue
- 5635
- Pages
- 969-972
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2071097210
- Cited by
- 725
- References
- 0
- FWCI
- 30.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nishimura, M. T., Stein, M., Hou, B.-H., Vogel, J. P., Edwards, H., & Somerville, S. C. (2003). Loss of a Callose Synthase Results in Salicylic Acid-Dependent Disease Resistance. Science. https://doi.org/10.1126/science.1086716
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