The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hairpin RNAs and Retrotransposon LTRs Effect RNAi and Chromatin-Based Gene Silencing
Open accessAbstract
The expression of short hairpin RNAs in several organisms silences gene expression by targeted mRNA degradation. This RNA interference (RNAi) pathway can also affect the genome, as DNA methylation arises at loci homologous to the target RNA in plants. We demonstrate in fission yeast that expression of a synthetic hairpin RNA is sufficient to silence the homologous locus in trans and causes the assembly of a patch of silent Swi6 chromatin with cohesin. This requires components of the RNAi machinery and Clr4 histone methyltransferase for small interfering RNA generation. A similar process represses several meiotic genes through nearby retrotransposon long terminal repeats (LTRs). These analyses directly implicate interspersed LTRs in regulating gene expression during cellular differentiation.
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Citations
Cites
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z.-W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., et al. (2000) · Nature · doi:10.1038/35020506 · Cited by 2,845
Cited by
DNA methylation and human disease
Robertson, K. D. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1655 · Cited by 2,864
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
Meister, G., Landthaler, M., Patkaniowska, A., Dorsett, Y., Teng, G., & Tuschl, T. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.07.007 · Cited by 2,052
Role of transposable elements in heterochromatin and epigenetic control
Lippman, Z., Gendrel, A.-V., Black, M., Vaughn, M. W., Dedhia, N., Richard McCombie, W., Lavine, K., Mittal, V., May, B., Kasschau, K. D., et al. (2004) · Nature · doi:10.1038/nature02651 · Cited by 1,065
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
Schotta, G., Lachner, M., Sarma, K., Ebert, A., Sengupta, R., Reuter, G., Reinberg, D., & Jenuwein, T. (2004) · Genes & Development · doi:10.1101/gad.300704 · Cited by 1,031
Retrotransposons regulate host genes in mouse oocytes and preimplantation embryos
Peaston, A. E., Evsikov, A. V., Graber, J. H., de Vries, W. N., Holbrook, A. E., Solter, D., & Knowles, B. B. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.004 · Cited by 710
Metadata
- Authors
- Schramke, V., & Allshire, R.
- Venue
- Science
- Published
- 2003-08-22
- Volume
- 301
- Issue
- 5636
- Pages
- 1069-1074
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070987160
- Cited by
- 307
- References
- 1
- FWCI
- 89.09
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- green
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- Schramke, V., & Allshire, R. (2003). Hairpin RNAs and Retrotransposon LTRs Effect RNAi and Chromatin-Based Gene Silencing. Science. https://doi.org/10.1126/science.1086870
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