The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Transport of dsRNA into Cells by the Transmembrane Protein SID-1
Abstract
RNA interference (RNAi) spreads systemically in plants and nematodes to silence gene expression distant from the site of initiation. We previously identified a gene, sid-1 , essential for systemic but not cell-autonomous RNAi in Caenorhabditis elegans . Here, we demonstrate that SID-1 is a multispan transmembrane protein that sensitizes Drosophila cells to soaking RNAi with a potency that is dependent on double-stranded RNA (dsRNA) length. Further analyses revealed that SID-1 enables passive cellular uptake of dsRNA. These data indicate that systemic RNAi in C. elegans involves SID-1–mediated intercellular transport of dsRNA.
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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
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Role for a bidentate ribonuclease in the initiation step of RNA interference
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Regulated portals of entry into the cell
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Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
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The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans
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Systemic RNAi in C. elegans Requires the Putative Transmembrane Protein SID-1
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Self-citationFunctional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli
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Cited by
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Large-Scale Sequencing Reveals 21U-RNAs and Additional MicroRNAs and Endogenous siRNAs in C. elegans
Ruby, J. G., Jan, C., Player, C., Axtell, M. J., Lee, W., Nusbaum, C., Ge, H., & Bartel, D. P. (2006) · Cell · doi:10.1016/j.cell.2006.10.040 · Cited by 983
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
Wolfrum, C., Shi, S., Jayaprakash, K. N., Jayaraman, M., Wang, G., Pandey, R. K., Rajeev, K. G., Nakayama, T., Charrise, K., Ndungo, E. M., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1339 · Cited by 974
Bidirectional cross-kingdom RNAi and fungal uptake of external RNAs confer plant protection
Wang, M., Weiberg, A., Lin, F.-M., Thomma, B. P. H. J., Huang, H.-D., & Jin, H. (2016) · Nature Plants · doi:10.1038/nplants.2016.151 · Cited by 801
Progress towards in Vivo Use of siRNAs
Behlke, M. A. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.01.001 · Cited by 677
Metadata
- Authors
- Feinberg, E. H., & Hunter, C. P.
- Venue
- Science
- Published
- 2003-09-12
- Volume
- 301
- Issue
- 5639
- Pages
- 1545-1547
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077293902
- Cited by
- 585
- References
- 19
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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