The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
A Seven-Transmembrane RGS Protein That Modulates Plant Cell Proliferation
Abstract
G protein–coupled receptors (GPCRs) at the cell surface activate heterotrimeric G proteins by inducing the G protein alpha (Gα) subunit to exchange guanosine diphosphate for guanosine triphosphate. Regulators of G protein signaling (RGS) proteins accelerate the deactivation of Gα subunits to reduce GPCR signaling. Here we identified an RGS protein (AtRGS1) in Arabidopsis that has a predicted structure similar to a GPCR as well as an RGS box with GTPase accelerating activity. Expression of AtRGS1 complemented the pheromone supersensitivity phenotype of a yeast RGS mutant, sst2 Δ. Loss of AtRGS1 increased the activity of the Arabidopsis Gα subunit, resulting in increased cell elongation in hypocotyls in darkness and increased cell production in roots grown in light. These findings suggest that AtRGS1 is a critical modulator of plant cell proliferation.
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Cited by
SUGAR SENSING AND SIGNALING IN PLANTS: Conserved and Novel Mechanisms
Rolland, F., Baena-Gonzalez, E., & Sheen, J. (2006) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105441 · Cited by 2,328
COLD1 Confers Chilling Tolerance in Rice
Ma, Y., Dai, X., Xu, Y., Luo, W., Zheng, X., Zeng, D., Pan, Y., Lin, X., Liu, H., Zhang, D., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.046 · Cited by 1,048
Heterotrimeric G Protein Signaling in Filamentous Fungi
Li, L., Wright, S. J., Krystofova, S., Park, G., & Borkovich, K. A. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093432 · Cited by 353
A protein kinase target of a PDK1 signalling pathway is involved in root hair growth in Arabidopsis
Anthony, R. G., Henriques, R., Helfer, A., Mészáros, T., Rios, G., Testerink, C., Munnik, T., Deák, M., Koncz, C., & Bögre, L. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600068 · Cited by 285
Plants: the latest model system for G‐protein research
Jones, A. M., & Assmann, S. M. (2004) · EMBO reports · doi:10.1038/sj.embor.7400174 · Cited by 261
Self-citation
Metadata
- Authors
- Chen, J.-G., Willard, F. S., Huang, J., Liang, J., Chasse, S. A., Jones, A. M., & Siderovski, D. P.
- Venue
- Science
- Published
- 2003-09-19
- Volume
- 301
- Issue
- 5640
- Pages
- 1728-1731
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2040383161
- Cited by
- 329
- References
- 15
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, J.-G., Willard, F. S., Huang, J., Liang, J., Chasse, S. A., Jones, A. M., & Siderovski, D. P. (2003). A Seven-Transmembrane RGS Protein That Modulates Plant Cell Proliferation. Science. https://doi.org/10.1126/science.1087790
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