The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help
Abstract
Spontaneous resolution of hepatitis C virus (HCV) infection in humans usually affords long-term immunity to persistent viremia and associated liver diseases. Here, we report that memory CD4 + Tcells are essential for this protection. Antibody-mediated depletion of CD4 + Tcells before reinfection of two immune chimpanzees resulted in persistent, low-level viremia despite functional intra-hepatic memory CD8 + Tcell responses. Incomplete control of HCV replication by memory CD8 + Tcells in the absence of adequate CD4 + Tcell help was associated with emergence of viral escape mutations in class I major histocompatibility complex–restricted epitopes and failure to resolve HCV infection.
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Citations
Cites
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G., & Schoenberger, S. P. (2003) · Nature · doi:10.1038/nature01441 · Cited by 1,635
Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help
Sun, J. C., & Bevan, M. J. (2003) · Science · doi:10.1126/science.1083317 · Cited by 1,213
Homann, D., Teyton, L., & Oldstone, M. B. A. (2001) · Nature Medicine · doi:10.1038/90950 · Cited by 587
Cited by
Deeks, S. G., & Walker, B. D. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.010 · Cited by 759
Immune responses and immunopathology in acute and chronic viral hepatitis
Shin, E.-C., Sung, P. S., & Park, S.-H. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.69 · Cited by 365
Nakamoto, N., Kaplan, D. E., Coleclough, J., Li, Y., Valiga, M. E., Kaminski, M., Shaked, A., Olthoff, K., Gostick, E., Price, D. A., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.02.033 · Cited by 299
Current status of interleukin-10 and regulatory T-cells in cancer
Dennis, K. L., Blatner, N. R., Gounari, F., & Khazaie, K. (2013) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000006 · Cited by 289
Jo, J., Aichele, U., Kersting, N., Klein, R., Aichele, P., Bisse, E., Sewell, A. K., Blum, H. E., Bartenschlager, R., Lohmann, V., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.12.034 · Cited by 131
Metadata
- Authors
- Grakoui, A., Shoukry, N. H., Woollard, D. J., Han, J.-H., Hanson, H. L., Ghrayeb, J., Murthy, K. K., Rice, C. M., & Walker, C. M.
- Venue
- Science
- Published
- 2003-10-24
- Volume
- 302
- Issue
- 5645
- Pages
- 659-662
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981136135
- Cited by
- 830
- References
- 3
- FWCI
- 32.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Grakoui, A., Shoukry, N. H., Woollard, D. J., Han, J.-H., Hanson, H. L., Ghrayeb, J., Murthy, K. K., Rice, C. M., & Walker, C. M. (2003). HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help. Science. https://doi.org/10.1126/science.1088774
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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