Cited by 289T-cell and B-cell ImmunologyCytokine Signaling Pathways and InteractionsImmune cells in cancer

Current status of interleukin-10 and regulatory T-cells in cancer

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Dennis, Kristen L., Blatner, Nichole R., Gounari, Fotini, Khazaie, Khashayarsha·2013·Current Opinion in Oncology

Abstract

PURPOSE OF REVIEW: Tumor growth elicits antigen-specific cytotoxic as well as immune suppressive responses. Interleukin-10 (IL-10) is a key immune-suppressive cytokine produced by regulatory T-cells and by helper T-cells. Here, we review pleiotropic functions of IL-10 that impact the immune pathology of cancer. RECENT FINDINGS: The role of IL-10 in cancer has become less certain with the knowledge of its immune stimulatory functions. IL-10 is needed for T-helper cell functions, T-cell immune surveillance, and suppression of cancer-associated inflammation. By promoting tumor-specific immune surveillance and hindering pathogenic inflammation, IL-10 is emerging as a key cytokine in the battle of the host against cancer. SUMMARY: IL-10 functions at the cross-roads of immune stimulation and immune suppression in cancer. Immunological mechanisms of action of IL-10 can be ultimately exploited to develop novel and effective cancer therapies.

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  • Cancer cells directly inhibit the immune system through molecules such as VEGF, prostaglandin E2, TGF-β, and IL-10, which suppress cytotoxic T-cell function.

    “Cancer cells also directly inhibit the immune system through molecules like vascular endothelial growth factor (VEGF), prostaglandin E2, transforming growth factor-β (TGF- β), and interleukin-10 (IL-10), which suppress cytotoxic T-cell function [77,78,80,81,82,83].”

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Authors
Dennis, K. L., Blatner, N. R., Gounari, F., & Khazaie, K.
Affiliations
  • Northwestern University (US)
  • University of Chicago (US)
Corresponding author
Khazaie, Khashayarsha
Venue
Current Opinion in Oncology
Published
2013-11
Volume
25
Issue
6
Pages
637-645
ISSN
1040-8746 (ISSN-L)
OpenAlex
W2085138770
Cited by
289
References
189
Citations by year
2026: 13 · 2025: 29 · 2024: 23 · 2023: 16 · 2022: 29 · 2021: 35 · 2020: 33 · 2019: 24 · 2018: 26 · 2017: 18 · 2016: 23 · 2015: 13 · 2014: 7
FWCI
1.25
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Oncology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (R01CA160436)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords
IL-10, regulatory T cells, tumor immunology, immunosuppression, T helper cells, tumor surveillance, tumor inflammation, immunostimulation, cancer therapy
MeSH terms
Animals, Antigens, Neoplasm, Dendritic Cells, Female, Humans, Immune Tolerance, Lymphocyte Activation, Male, Neoplasms, T-Lymphocyte Subsets, Interleukin-10, Cell Line, Tumor, Cell Proliferation, T-Lymphocytes, Regulatory, Mice, Immunomodulation

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