Current status of interleukin-10 and regulatory T-cells in cancer
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PURPOSE OF REVIEW: Tumor growth elicits antigen-specific cytotoxic as well as immune suppressive responses. Interleukin-10 (IL-10) is a key immune-suppressive cytokine produced by regulatory T-cells and by helper T-cells. Here, we review pleiotropic functions of IL-10 that impact the immune pathology of cancer. RECENT FINDINGS: The role of IL-10 in cancer has become less certain with the knowledge of its immune stimulatory functions. IL-10 is needed for T-helper cell functions, T-cell immune surveillance, and suppression of cancer-associated inflammation. By promoting tumor-specific immune surveillance and hindering pathogenic inflammation, IL-10 is emerging as a key cytokine in the battle of the host against cancer. SUMMARY: IL-10 functions at the cross-roads of immune stimulation and immune suppression in cancer. Immunological mechanisms of action of IL-10 can be ultimately exploited to develop novel and effective cancer therapies.
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Cancer cells directly inhibit the immune system through molecules such as VEGF, prostaglandin E2, TGF-β, and IL-10, which suppress cytotoxic T-cell function.
“Cancer cells also directly inhibit the immune system through molecules like vascular endothelial growth factor (VEGF), prostaglandin E2, transforming growth factor-β (TGF- β), and interleukin-10 (IL-10), which suppress cytotoxic T-cell function [77,78,80,81,82,83].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [83]
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Innovative CAR-T Cell Therapy for Solid Tumor; Current Duel between CAR-T Spear and Tumor Shield
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- Authors
- Dennis, K. L., Blatner, N. R., Gounari, F., & Khazaie, K.
- Affiliations
- Northwestern University (US)
- University of Chicago (US)
- Corresponding author
- Khazaie, Khashayarsha
- Venue
- Current Opinion in Oncology
- Published
- 2013-11
- Volume
- 25
- Issue
- 6
- Pages
- 637-645
- ISSN
- 1040-8746 (ISSN-L)
- PMC
- PMC4322764
- OpenAlex
- W2085138770
- Cited by
- 289
- References
- 189
- Citations by year
- 2026: 13 · 2025: 29 · 2024: 23 · 2023: 16 · 2022: 29 · 2021: 35 · 2020: 33 · 2019: 24 · 2018: 26 · 2017: 18 · 2016: 23 · 2015: 13 · 2014: 7
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Oncology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA160436)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- IL-10, regulatory T cells, tumor immunology, immunosuppression, T helper cells, tumor surveillance, tumor inflammation, immunostimulation, cancer therapy
- MeSH terms
- Animals, Antigens, Neoplasm, Dendritic Cells, Female, Humans, Immune Tolerance, Lymphocyte Activation, Male, Neoplasms, T-Lymphocyte Subsets, Interleukin-10, Cell Line, Tumor, Cell Proliferation, T-Lymphocytes, Regulatory, Mice, Immunomodulation
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