The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains
Abstract
Interactions between ends from different DNA double-strand breaks (DSBs) can produce tumorigenic chromosome translocations. Two theories for the juxta-position of DSBs in translocations, the static "contact-first" and the dynamic "breakage-first" theory, differ fundamentally in their requirement for DSB mobility. To determine whether or not DSB-containing chromosome domains are mobile and can interact, we introduced linear tracks of DSBs in nuclei. We observed changes in track morphology within minutes after DSB induction, indicating movement of the domains. In a subpopulation of cells, the domains clustered. Juxtaposition of different DSB-containing chromosome domains through clustering, which was most extensive in G1 phase cells, suggests an adhesion process in which we implicate the Mre11 complex. Our results support the breakage-first theory to explain the origin of chromosomal translocations.
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“DSBs have the potential to directly affect the 3D genome organization”
From Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration (2023) · cites this paper as [53]
Citations
Cites
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DNA double-strand break repair-pathway choice in somatic mammalian cells
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DNA Double-Strand Break Repair: All's Well that Ends Well
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Self-citation
Metadata
- Authors
- Aten, J. A., Stap, J., Krawczyk, P. M., van Oven, C. H., Hoebe, R. A., Essers, J., & Kanaar, R.
- Affiliations
- Erasmus MC (NL)
- Center for Microscopical Research, Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, Netherlands.
- Corresponding author
- Kanaar, Roland
- Venue
- Science
- Published
- 2004-01-02
- Volume
- 303
- Issue
- 5654
- Pages
- 92-95
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2041251646
- Cited by
- 491
- References
- 21
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 11 · 2023: 18 · 2022: 12 · 2021: 23 · 2020: 18 · 2019: 17 · 2018: 26 · 2017: 26 · 2016: 16 · 2015: 17 · 2014: 22 · 2013: 26 · 2012: 24
- FWCI
- 13.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- DNA double-strand breaks, chromosomal translocation, Mre11 complex, G1 phase, carcinogenesis
- MeSH terms
- MRE11 Homologue Protein, Alpha Particles, Animals, Ataxia Telangiectasia, Cell Nucleus, Chromosomes, Human, Cricetulus, DNA, DNA Damage, DNA Repair, DNA-Binding Proteins, Fibroblasts, Cricetinae, HeLa Cells, Histones, Humans, Phosphorylation, Translocation, Genetic, G1 Phase, G2 Phase, S Phase, CHO Cells, Chromosome Breakage, Chromosomes, Mammalian, Rad51 Recombinase
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