The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
T Cell Activation by Lipopeptide Antigens
Abstract
Unlike major histocompatibility proteins, which bind peptides, CD1 proteins display lipid antigens to T cells. Here, we report that CD1a presents a family of previously unknown lipopeptides from Mycobacterium tuberculosis , named didehydroxymycobactins because of their structural relation to mycobactin siderophores. T cell activation was mediated by the αβ T cell receptors and was specific for structure of the acyl and peptidic components of these antigens. These studies identify a means of intracellular pathogen detection and identify lipopeptides as a biochemical class of antigens for T cells, which, like conventional peptides, have a potential for marked structural diversity.
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Cites
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
Kraulis, P. J. (1991) · Journal of Applied Crystallography · doi:10.1107/s0021889891004399 · Cited by 14,085
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
Nicholls, A., Sharp, K. A., & Honig, B. (1991) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.340110407 · Cited by 5,240
Mellman, I., & Steinman, R. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00449-4 · Cited by 2,237
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
Garboczi, D. N., Ghosh, P., Utz, U., Fan, Q. R., Biddison, W. E., & Wiley, D. C. (1996) · Nature · doi:10.1038/384134a0 · Cited by 1,424
An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex
Garcia, K. C., Degano, M., Stanfield, R. L., Brunmark, A., Jackson, M. R., Peterson, P. A., Teyton, L., & Wilson, I. A. (1996) · Science · doi:10.1126/science.274.5285.209 · Cited by 1,302
Self-citationRecognition of a lipid antigen by CD1-restricted αβ+ T cells
Beckman, E. M., Porcelli, S. A., Morita, C. T., Behar, S. M., Furlong, S. T., & Brenner, M. B. (1994) · Nature · doi:10.1038/372691a0 · Cited by 978
Self-citationGenetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria
Crosa, J. H., & Walsh, C. T. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.223-249.2002 · Cited by 797
Protein Lipidation in Cell Signaling
Casey, P. J. (1995) · Science · doi:10.1126/science.7716512 · Cited by 774
Crystal Structure of Mouse CD1: An MHC-Like Fold with a Large Hydrophobic Binding Groove
Zeng, Z.-H., Castaño, A. R., Segelke, B. W., Stura, E. A., Peterson, P. A., & Wilson, I. A. (1997) · Science · doi:10.1126/science.277.5324.339 · Cited by 630
Self-citation
Cited by
Siderophore-Based Iron Acquisition and Pathogen Control
Miethke, M., & Marahiel, M. A. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00012-07 · Cited by 1,774
Mycobactin-mediated iron acquisition within macrophages
Luo, M., Fadeev, E. A., & Groves, J. T. (2005) · Nature Chemical Biology · doi:10.1038/nchembio717 · Cited by 141
General aspects and neuropathology of X-linked adrenoleukodystrophy
Ferrer, I., Aubourg, P., & Pujol, A. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2010.00390.x · Cited by 139
Recognition of microbial glycolipids by natural killer T cells
Zajonc, D. M., & Girardi, E. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00400 · Cited by 76
Self-citationLipid-binding Proteins in Membrane Digestion, Antigen Presentation, and Antimicrobial Defense
Kolter, T., Winau, F., Schaible, U. E., Leippe, M., & Sandhoff, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.r500015200 · Cited by 73
Metadata
- Authors
- Moody, D. B., Young, D. C., Cheng, T.-Y., Rosat, J.-P., Roura-mir, C., O'Connor, P. B., Zajonc, D. M., Walz, A., Miller, M. J., Levery, S. B., Wilson, I. A., Costello, C. E., & Brenner, M. B.
- Venue
- Science
- Published
- 2004-01-23
- Volume
- 303
- Issue
- 5657
- Pages
- 527-531
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2142960791
- Cited by
- 265
- References
- 34
- FWCI
- 15.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Moody, D. B., Young, D. C., Cheng, T.-Y., Rosat, J.-P., Roura-mir, C., O'Connor, P. B., Zajonc, D. M., Walz, A., Miller, M. J., Levery, S. B., Wilson, I. A., Costello, C. E., & Brenner, M. B. (2004). T Cell Activation by Lipopeptide Antigens. Science. https://doi.org/10.1126/science.1089353
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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