The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Three-Dimensional Structure of Herpes Simplex Virus from Cryo-Electron Tomography
Abstract
Herpes simplex virus, a DNA virus of high complexity, consists of a nucleocapsid surrounded by the tegument—a protein compartment—and the envelope. The latter components, essential for infectivity, are pleiomorphic. Visualized in cryo–electron tomograms of isolated virions, the tegument was seen to form an asymmetric cap: On one side, the capsid closely approached the envelope; on the other side, they were separated by ∼35 nanometers of tegument. The tegument substructure was particulate, with some short actin-like filaments. The envelope contained 600 to 750 glycoprotein spikes that varied in length, spacing, and in the angles at which they emerge from the membrane. Their distribution was nonrandom, suggesting functional clustering.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Signaling Through Scaffold, Anchoring, and Adaptor Proteins
Pawson, T., & Scott, J. D. (1997) · Science · doi:10.1126/science.278.5346.2075 · Cited by 2,256
Paxillin and focal adhesion signalling
Turner, C. E. (2000) · Nature Cell Biology · doi:10.1038/35046659 · Cited by 839
Macromolecular Architecture in Eukaryotic Cells Visualized by Cryoelectron Tomography
Medalia, O., Weber, I., Frangakis, A. S., Nicastro, D., Gerisch, G., & Baumeister, W. (2002) · Science · doi:10.1126/science.1076184 · Cited by 837
Self-citationHerpesvirus Assembly and Egress
Mettenleiter, T. C. (2002) · Journal of Virology · doi:10.1128/jvi.76.4.1537-1547.2002 · Cited by 613
Chiu, W., Burnett, R. M., & Garcea, R. L. (1997) · Oxford University Press eBooks · Cited by 532
Three Classes of Cell Surface Receptors for Alphaherpesvirus Entry
Spear, P. G., Eisenberg, R. J., & Cohen, G. H. (2000) · Virology · doi:10.1006/viro.2000.0529 · Cited by 516
Noise Reduction in Electron Tomographic Reconstructions Using Nonlinear Anisotropic Diffusion
Frangakis, A. S., & Hegerl, R. (2001) · Journal of Structural Biology · doi:10.1006/jsbi.2001.4406 · Cited by 423
Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor HveA
Carfı́, A., Willis, S. H., Whitbeck, J. C., Krummenacher, C., Cohen, G. H., Eisenberg, R. J., & Wiley, D. C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00298-2 · Cited by 391
Seeing the Herpesvirus Capsid at 8.5 Å
Zhou, Z. H., Dougherty, M., Jakana, J., He, J., Rixon, F. J., & Chiu, W. (2000) · Science · doi:10.1126/science.288.5467.877 · Cited by 317
The UL6 Gene Product Forms the Portal for Entry of DNA into the Herpes Simplex Virus Capsid
Newcomb, W. W., Juhas, R. M., Thomsen, D. R., Homa, F. L., Burch, A. D., Weller, S. K., & Brown, J. C. (2001) · Journal of Virology · doi:10.1128/jvi.75.22.10923-10932.2001 · Cited by 309
Cited by
Canton, I., & Battaglia, G. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15309b · Cited by 936
Molecular Biology of Pseudorabies Virus: Impact on Neurovirology and Veterinary Medicine
Pomeranz, L. E., Reynolds, A. E., & Hengartner, C. J. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.3.462-500.2005 · Cited by 869
Outcome of the first electron microscopy validation task force meeting
Henderson, R., Sali, A., Baker, M. L., Carragher, B., Devkota, B., Downing, K. H., Egelman, E. H., Feng, Z., Frank, J., Grigorieff, N., et al. (2012) · Structure · doi:10.1016/j.str.2011.12.014 · Cited by 505
Self-citation(2014) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-53488-0.00011-0 · Cited by 474
Proteins of purified Epstein-Barr virus
Johannsen, E., Luftig, M., Chase, M. R., Weicksel, S., Cahir-McFarland, E., Illanes, D., Sarracino, D., & Kieff, E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407320101 · Cited by 450
Metadata
- Authors
- Grünewald, K., Desai, P., Winkler, D. C., Heymann, J. B., Belnap, D. M., Baumeister, W., & Steven, A. C.
- Venue
- Science
- Published
- 2003-11-21
- Volume
- 302
- Issue
- 5649
- Pages
- 1396-1398
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081460107
- Cited by
- 586
- References
- 23
- FWCI
- 24.78
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Three-Dimensional Structure of Herpes Simplex Virus from Cryo-Electron Tomography. https://app.cochat.ai/papers/10.1126/science.1090284
- The paper
- Grünewald, K., Desai, P., Winkler, D. C., Heymann, J. B., Belnap, D. M., Baumeister, W., & Steven, A. C. (2003). Three-Dimensional Structure of Herpes Simplex Virus from Cryo-Electron Tomography. Science. https://doi.org/10.1126/science.1090284
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
