The DOI matches its Crossref record; 292 of the 292 references it cites were found in a registry or an index.
Molecular Biology of Pseudorabies Virus: Impact on Neurovirology and Veterinary Medicine
Open accessAbstract
SUMMARY: Pseudorabies virus (PRV) is a herpesvirus of swine, a member of the Alphaherpesvirinae subfamily, and the etiological agent of Aujeszky's disease. This review describes the contributions of PRV research to herpesvirus biology, neurobiology, and viral pathogenesis by focusing on (i) the molecular biology of PRV, (ii) model systems to study PRV pathogenesis and neurovirulence, (iii) PRV transsynaptic tracing of neuronal circuits, and (iv) veterinary aspects of pseudorabies disease. The structure of the enveloped infectious particle, the content of the viral DNA genome, and a step-by-step overview of the viral replication cycle are presented. PRV infection is initiated by binding to cellular receptors to allow penetration into the cell. After reaching the nucleus, the viral genome directs a regulated gene expression cascade that culminates with viral DNA replication and production of new virion constituents. Finally, progeny virions self-assemble and exit the host cells. Animal models and neuronal culture systems developed for the study of PRV pathogenesis and neurovirulence are discussed. PRV serves as a self-perpetuating transsynaptic tracer of neuronal circuitry, and we detail the original studies of PRV circuitry mapping, the biology underlying this application, and the development of the next generation of tracer viruses. The basic veterinary aspects of pseudorabies management and disease in swine are discussed. PRV infection progresses from acute infection of the respiratory epithelium to latent infection in the peripheral nervous system. Sporadic reactivation from latency can transmit PRV to new hosts. The successful management of PRV disease has relied on vaccination, prevention, and testing.
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Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein
Ulmer, J. B., Donnelly, J. J., Parker, S. E., Rhodes, G. H., Felgner, P. L., Dwarki, V. J., Gromkowski, S. H., Deck, R. R., DeWitt, C. M., Friedman, A., et al. (1993) · Science · doi:10.1126/science.8456302 · Cited by 2,318
Stein, C., Manthei, C. A., Rd, S., & Torrey, J. P. (1952) · U.S. Dept. of Agriculture eBooks · Cited by 1,654
The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1
McGeoch, D. J., Dalrymple, M. A., Davison, A. J., Dolan, A., Frame, M. C., McNab, D., Perry, L. J., Scott, J. E., & Taylor, P. (1988) · Journal of General Virology · doi:10.1099/0022-1317-69-7-1531 · Cited by 1,618
Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate
Kelly, R. M., & Strick, P. L. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-23-08432.2003 · Cited by 1,595
Genetic immunization is a simple method for eliciting an immune response
Tang, D.-C., DeVit, M., & Johnston, S. A. (1992) · Nature · doi:10.1038/356152a0 · Cited by 1,498
Whitley, R. J., Kimberlin, D. W., & Roizman, B. (1998) · Clinical Infectious Diseases · doi:10.1086/514600 · Cited by 1,149
The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
Bareyre, F. M., Kerschensteiner, M., Raineteau, O., Mettenleiter, T. C., Weinmann, O., & Schwab, M. E. (2004) · Nature Neuroscience · doi:10.1038/nn1195 · Cited by 1,086
Geraghty, R. J., Krummenacher, C., Cohen, G. H., Eisenberg, R. J., & Spear, P. G. (1998) · Science · doi:10.1126/science.280.5369.1618 · Cited by 909
Hata, A. N., & Breyer, R. M. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.06.003 · Cited by 840
Experimental Study of Channel Patterns
SCHUMM, S. A., & KHAN, H. R. (1972) · Geological Society of America Bulletin · doi:10.1130/0016-7606(1972)83[1755:esocp]2.0.co;2 · Cited by 776
Cited by
Nectow, A. R., & Nestler, E. J. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-00382-z · Cited by 159
Proteomic Characterization of Pseudorabies Virus Extracellular Virions
Kramer, T., Greco, T. M., Enquist, L. W., & Cristea, I. M. (2011) · Journal of Virology · doi:10.1128/jvi.02253-10 · Cited by 96
Laval, K., Van Cleemput, J., Vernejoul, J. B., & Enquist, L. W. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008087 · Cited by 36
Holz, C. L., Nelli, R. K., Wilson, M. E., Zarski, L. M., Azab, W., Baumgardner, R., Osterrieder, N., Pease, A., Zhang, L., Hession, S., et al. (2017) · Journal of General Virology · doi:10.1099/jgv.0.000773 · Cited by 34
Setas Pontes, M., Devriendt, B., & Favoreel, H. W. (2015) · Journal of Virology · doi:10.1128/jvi.02549-14 · Cited by 15
Metadata
- Authors
- Pomeranz, L. E., Reynolds, A. E., & Hengartner, C. J.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2005-09
- Volume
- 69
- Issue
- 3
- Pages
- 462-500
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- OpenAlex
- W2121266203
- Cited by
- 869
- References
- 292
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Pomeranz, L. E., Reynolds, A. E., & Hengartner, C. J. (2005). Molecular Biology of Pseudorabies Virus: Impact on Neurovirology and Veterinary Medicine. Microbiology and Molecular Biology Reviews. https://doi.org/10.1128/mmbr.69.3.462-500.2005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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