The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Localized Stabilization of Microtubules by Integrin- and FAK-Facilitated Rho Signaling
Abstract
Microtubule (MT) stabilization is regulated by the small guanosine triphosphate (GTP)–binding protein Rho and its effector, mammalian homolog of Diaphanous (mDia), in migrating cells, but factors responsible for localized stabilization at the leading edge are unknown. We report that integrin-mediated activation of focal adhesion kinase (FAK) at the leading edge is required for MT stabilization by the Rho-mDia signaling pathway in mouse fibroblasts. MT stabilization also involved FAK-regulated localization of a lipid raft marker, ganglioside G M1 , to the leading edge. The integrin-FAK signaling pathway may facilitate Rho-mDia signaling through G M1 , or through a specialized membrane domain containing G M1 , to stabilize MTs in the leading edge of migrating cells.
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Citations
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Microtubules and signal transduction
Gundersen, G. G., & Cook, T. A. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80010-6 · Cited by 407
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Mitra, S. K., Hanson, D. A., & Schlaepfer, D. D. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1549 · Cited by 2,335
Self-citationTargeting integrin pathways: mechanisms and advances in therapy
Pang, X., He, X., Qiu, Z., Zhang, H., Xie, R., Liu, Z., Gu, Y., Zhao, N., Xiang, Q., & Cui, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01259-6 · Cited by 1,275
Mechanical regulation of bone remodeling
Wang, L., You, X., Zhang, L., Zhang, C., & Zou, W. (2022) · Bone Research · doi:10.1038/s41413-022-00190-4 · Cited by 641
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Dogterom, M., & Koenderink, G. H. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0067-1 · Cited by 574
EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration
Wen, Y., Eng, C. H., Schmoranzer, J., Cabrera-Poch, N., Morris, E. J. S., Chen, M., Wallar, B. J., Alberts, A. S., & Gundersen, G. G. (2004) · Nature Cell Biology · doi:10.1038/ncb1160 · Cited by 560
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Metadata
- Authors
- Palazzo, A. F., Eng, C. H., Schlaepfer, D. D., Marcantonio, E. E., & Gundersen, G. G.
- Venue
- Science
- Published
- 2004-02-06
- Volume
- 303
- Issue
- 5659
- Pages
- 836-839
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2129251085
- Cited by
- 416
- References
- 1
- FWCI
- 15.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Palazzo, A. F., Eng, C. H., Schlaepfer, D. D., Marcantonio, E. E., & Gundersen, G. G. (2004). Localized Stabilization of Microtubules by Integrin- and FAK-Facilitated Rho Signaling. Science. https://doi.org/10.1126/science.1091325
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