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Crosstalk Between the EGFR and LIN-12/Notch Pathways in C. elegans Vulval Development
Abstract
The Caenorhabditis elegans vulva is an important paradigm for cell-cell interactions in animal development. The fates of six vulval precursor cells are patterned through the action of the epidermal growth factor receptor–mitogen-activated protein kinase (EGFR-MAPK) inductive signaling pathway, which specifies the 1° fate, and the LIN-12/Notch lateral signaling pathway, which specifies the 2° fate. Here, we provide evidence that the inductive signal is spatially graded and initially activates the EGFR-MAPK pathway in the prospective 2° cells. Subsequently, this effect is counteracted by the expression of multiple new negative regulators of the EGFR-MAPK pathway, under direct transcriptional control of the LIN-12–mediated lateral signal.
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Cited by
Bray, S. J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.94 · Cited by 1,012
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Shi, W., Zeng, H., Sahoo, Y., Ohulchanskyy, T. Y., Ding, Y., Wang, Z. L., Swihart, M., & Prasad, P. N. (2006) · Nano Letters · doi:10.1021/nl0600833 · Cited by 608
Robustness and evolution: concepts, insights and challenges from a developmental model system
Félix, M.-A., & Wagner, A. (2008) · Heredity · doi:10.1038/sj.hdy.6800915 · Cited by 210
Franzke, C.-W., Cobzaru, C., Triantafyllopoulou, A., Löffek, S., Horiuchi, K., Threadgill, D. W., Kurz, T., van Rooijen, N., Bruckner-Tuderman, L., & Blobel, C. P. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112258 · Cited by 186
C. elegans Notch signaling regulates adult chemosensory response and larval molting quiescence
Singh, K., Chao, M. Y., Somers, G. A., Komatsu, H., Corkins, M. E., Larkins-Ford, J., Tucey, T., Dionne, H. M., Walsh, M. B., Beaumont, E. K., et al. (2011) · Current Biology · doi:10.1016/j.cub.2011.04.010 · Cited by 137
Metadata
- Authors
- Yoo, A. S., Bais, C., & Greenwald, I.
- Venue
- Science
- Published
- 2004-01-30
- Volume
- 303
- Issue
- 5658
- Pages
- 663-666
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1987179641
- Cited by
- 254
- References
- 0
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Crosstalk Between the EGFR and LIN-12/Notch Pathways in C. elegans Vulval Development. https://app.cochat.ai/papers/10.1126/science.1091639
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- Yoo, A. S., Bais, C., & Greenwald, I. (2004). Crosstalk Between the EGFR and LIN-12/Notch Pathways in C. elegans Vulval Development. Science. https://doi.org/10.1126/science.1091639
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
