Robustness and evolution: concepts, insights and challenges from a developmental model system

Félix, M-A; Wagner, A

doi:10.1038/sj.hdy.6800915

Cited by 211Evolution and Genetic DynamicsPhilosophy and History of ScienceDevelopmental Biology and Gene Regulation

Robustness and evolution: concepts, insights and challenges from a developmental model system

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Félix, M-A, Wagner, A·2008·Heredity

DOI 10.1038/sj.hdy.6800915

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Abstract

Robustness, the persistence of an organismal trait under perturbations, is a ubiquitous property of complex living systems. We here discuss key concepts related to robustness with examples from vulva development in the nematode Caenorhabditis elegans. We emphasize the need to be clear about the perturbations a trait is (or is not) robust to. We discuss two prominent mechanistic causes of robustness, namely redundancy and distributed robustness. We also discuss possible evolutionary causes of robustness, one of which does not involve natural selection. To better understand robustness is of paramount importance for understanding organismal evolution. Part of the reason is that highly robust systems can accumulate cryptic variation that can serve as a source of new adaptations and evolutionary innovations. We point to some key challenges in improving our understanding of robustness.

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Many biochemical networks are robust-remarkably stable under changes in external conditions and internal reaction parameters.
“The functioning of many biochemical networks is often robust - remarkably stable under changes in external conditions and internal reaction parameters.”
From Sloppiness, robustness, and evolvability in systems biology (2008) · cites this paper as [5]

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Authors: Félix, M.-A., & Wagner, A.
Affiliations: Centre National de la Recherche Scientifique (FR)
University of Zurich (CH)
ORCID: Félix, M-A
Wagner, A
Venue: Heredity
Publisher: Springer Science and Business Media LLC
Published: 2006-12-13
Volume: 100
Issue: 2
Pages: 132-140
ISSN: 0018-067X (ISSN-L)
1365-2540
DOI: 10.1038/sj.hdy.6800915
OpenAlex: W2147777139
Cited by: 210
References: 93
Citations by year: 2026: 7 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 15 · 2021: 7 · 2020: 17 · 2019: 8 · 2018: 17 · 2017: 5 · 2016: 10 · 2015: 14 · 2014: 13 · 2013: 12 · 2012: 12
FWCI: 0.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Heredity (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
HAL (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich)
Funders: Agence Nationale de la Recherche (ANR-05)
Centre National de la Recherche Scientifique
National Institutes of Health
National Institute of General Medical Sciences (R01GM063882, GM63882)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: robustness, vulval development, Caenorhabditis elegans, redundancy, cryptic variation, evolutionary innovation, developmental robustness, natural selection
MeSH terms: Animals, Biological Evolution, Female, Vulva, Caenorhabditis elegans

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Robustness and evolution: concepts, insights and challenges from a developmental model system

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