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EGF-Like Growth Factors As Mediators of LH Action in the Ovulatory Follicle
Abstract
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.
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Citations
Cited by
Stocco, D. M., Wang, X., Jo, Y., & Manna, P. R. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0532 · Cited by 538
Ovulation: Parallels With Inflammatory Processes
Duffy, D. M., Ko, C., Jo, M., Brannstrom, M., & Curry, T. E. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00075 · Cited by 513
Day, F. R., Hinds, D. A., Tung, J. Y., Stolk, L., Styrkarsdottir, U., Saxena, R., Bjonnes, A., Broer, L., Dunger, D. B., Halldorsson, B. V., et al. (2015) · Nature Communications · doi:10.1038/ncomms9464 · Cited by 459
The epidermal growth factor receptor ligands at a glance
Schneider, M. R., & Wolf, E. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21635 · Cited by 447
Hsieh, M., Lee, D., Panigone, S., Horner, K., Chen, R., Theologis, A., Lee, D. C., Threadgill, D. W., & Conti, M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01919-06 · Cited by 329
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Metadata
- Authors
- Park, J.-Y., Su, Y.-Q., Ariga, M., Law, E., Jin, S.-L. C., & Conti, M.
- Venue
- Science
- Published
- 2004-01-30
- Volume
- 303
- Issue
- 5658
- Pages
- 682-684
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084172300
- Cited by
- 1,047
- References
- 0
- FWCI
- 48.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Park, J.-Y., Su, Y.-Q., Ariga, M., Law, E., Jin, S.-L. C., & Conti, M. (2004). EGF-Like Growth Factors As Mediators of LH Action in the Ovulatory Follicle. Science. https://doi.org/10.1126/science.1092463
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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