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RAD51C Is Required for Holliday Junction Processing in Mammalian Cells
Abstract
During genetic recombination and the recombinational repair of chromosome breaks, DNA molecules become linked at points of strand exchange. Branch migration and resolution of these crossovers, or Holliday junctions (HJs), complete the recombination process. Here, we show that extracts from cells carrying mutations in the recombination/repair genes RAD51C or XRCC3 have reduced levels of HJresolvase activity. Moreover, depletion of RAD51C from fractionated human extracts caused a loss of branch migration and resolution activity, but these functions were restored by complementation with a variety of RAD51 paralog complexes containing RAD51C. We conclude that the RAD51 paralogs are involved in HJprocessing in human cells.
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Cited by
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Palm, W., & de Lange, T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130350 · Cited by 1,802
Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins
Prakash, R., Zhang, Y., Feng, W., & Jasin, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016600 · Cited by 869
Meindl, A., Hellebrand, H., Wiek, C., Erven, V., Wappenschmidt, B., Niederacher, D., Freund, M., Lichtner, P., Hartmann, L., Schaal, H., et al. (2010) · Nature Genetics · doi:10.1038/ng.569 · Cited by 743
Mutation of the RAD51C gene in a Fanconi anemia–like disorder
Vaz, F., Hanenberg, H., Schuster, B., Barker, K., Wiek, C., Erven, V., Neveling, K., Endt, D., Kesterton, I., Autore, F., et al. (2010) · Nature Genetics · doi:10.1038/ng.570 · Cited by 408
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia
Levran, O., Attwooll, C., Henry, R. T., Milton, K. L., Neveling, K., Rio, P., Batish, S. D., Kalb, R., Velleuer, E., Barral, S., et al. (2005) · Nature Genetics · doi:10.1038/ng1624 · Cited by 370
Metadata
- Authors
- Liu, Y., Masson, J.-Y., Shah, R., O'Regan, P., & West, S. C.
- Venue
- Science
- Published
- 2004-01-09
- Volume
- 303
- Issue
- 5655
- Pages
- 243-246
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2135597217
- Cited by
- 311
- References
- 0
- FWCI
- 17.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, Y., Masson, J.-Y., Shah, R., O'Regan, P., & West, S. C. (2004). RAD51C Is Required for Holliday Junction Processing in Mammalian Cells. Science. https://doi.org/10.1126/science.1093037
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