The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Structure and Receptor Binding Properties of the 1918 Influenza Hemagglutinin
Abstract
The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibilitythat, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closelyrelated HAs in complex with receptor analogs. Theyexplain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.
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Citations
Cites
Origin and evolution of the 1918 “Spanish” influenza virus hemagglutinin gene
Reid, A. H., Fanning, T. G., Hultin, J. V., & Taubenberger, J. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1651 · Cited by 607
Cited by
Antibody Recognition of a Highly Conserved Influenza Virus Epitope
Ekiert, D. C., Bhabha, G., Elsliger, M.-A., Friesen, R. H. E., Jongeneelen, M., Throsby, M., Goudsmit, J., & Wilson, I. A. (2009) · Science · doi:10.1126/science.1171491 · Cited by 1,326
Almond, D. (2006) · Journal of Political Economy · doi:10.1086/507154 · Cited by 1,190
Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus
Stevens, J., Blixt, O., Tumpey, T. M., Taubenberger, J. K., Paulson, J. C., & Wilson, I. A. (2006) · Science · doi:10.1126/science.1124513 · Cited by 938
Cross-Species Virus Transmission and the Emergence of New Epidemic Diseases
Parrish, C. R., Holmes, E. C., Morens, D. M., Park, E.-C., Burke, D. S., Calisher, C. H., Laughlin, C. A., Saif, L. J., & Daszak, P. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00004-08 · Cited by 834
Stevens, J., Blixt, O., Glaser, L., Taubenberger, J. K., Palese, P., Paulson, J. C., & Wilson, I. A. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.11.002 · Cited by 613
Metadata
- Authors
- Gamblin, S. J., Haire, L. F., Russell, R. J., Stevens, D. J., Xiao, B., Ha, Y., Vasisht, N., Steinhauer, D. A., Daniels, R. S., Elliot, A., Wiley, D. C., & Skehel, J. J.
- Venue
- Science
- Published
- 2004-03-19
- Volume
- 303
- Issue
- 5665
- Pages
- 1838-1842
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2114289644
- Cited by
- 712
- References
- 1
- FWCI
- 31.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gamblin, S. J., Haire, L. F., Russell, R. J., Stevens, D. J., Xiao, B., Ha, Y., Vasisht, N., Steinhauer, D. A., Daniels, R. S., Elliot, A., Wiley, D. C., & Skehel, J. J. (2004). The Structure and Receptor Binding Properties of the 1918 Influenza Hemagglutinin. Science. https://doi.org/10.1126/science.1093155
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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