The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus
Abstract
The hemagglutinin (HA) structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA. Glycan microarray analysis of this Viet04 HA reveals an avian α2-3 sialic acid receptor binding preference. Introduction of mutations that can convert H1 serotype HAs to human α2-6 receptor specificity only enhanced or reduced affinity for avian-type receptors. However, mutations that can convert avian H2 and H3 HAs to human receptor specificity, when inserted onto the Viet04 H5 HA framework, permitted binding to a natural human α2-6 glycan, which suggests a path for this H5N1 virus to gain a foothold in the human population.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin
Skehel, J. J., & Wiley, D. C. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.531 · Cited by 2,706
Updating the accounts: global mortality of the 1918–1920 "Spanish" influenza pandemic.
Johnson, N. P. A. S., & Mueller, J. (2002) · Bulletin of the History of Medicine · doi:10.1353/bhm.2002.0022 · Cited by 1,980
Wiley, D. C., Wilson, I. A., & Skehel, J. J. (1981) · Nature · doi:10.1038/289373a0 · Cited by 1,615
Self-citationFouchier, R. A. M., Munster, V., Wallensten, A., Bestebroer, T. M., Herfst, S., Smith, D., Rimmelzwaan, G. F., Olsen, B., & Osterhaus, A. D. M. E. (2005) · Journal of Virology · doi:10.1128/jvi.79.5.2814-2822.2005 · Cited by 1,563
Characterization of the reconstructed 1918 Spanish influenza pandemic virus
Tumpey, T. M., Basler, C. F., Aguilar, P. V., Zeng, H., Solórzano, A., Swayne, D. E., Cox, N. J., Katz, J. M., Taubenberger, J. K., Palese, P., et al. (2005) · Science · doi:10.1126/science.1119392 · Cited by 1,327
Self-citationAvian Influenza A (H5N1) Infection in Humans
(2005) · New England Journal of Medicine · doi:10.1056/nejmra052211 · Cited by 1,285
Printed covalent glycan array for ligand profiling of diverse glycan binding proteins
Blixt, O., Head, S., Mondala, T., Scanlan, C., Huflejt, M. E., Alvarez, R., Bryan, M. C., Fazio, F., Calarese, D., Stevens, J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407902101 · Cited by 1,101
Self-citationCharacterization of the 1918 influenza virus polymerase genes
Taubenberger, J. K., Reid, A. H., Lourens, R. M., Wang, R., Jin, G., & Fanning, T. G. (2005) · Nature · doi:10.1038/nature04230 · Cited by 1,066
Self-citationThe antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype)
Caton, A. J., Brownlee, G. G., Yewdell, J. W., & Gerhard, W. (1982) · Cell · doi:10.1016/0092-8674(82)90135-0 · Cited by 1,034
Baculovirus as versatile vectors for protein expression in insect and mammalian cells
Kost, T. A., Condreay, J. P., & Jarvis, D. L. (2005) · Nature Biotechnology · doi:10.1038/nbt1095 · Cited by 1,014
Cited by
Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635
“Much has been written about the specificity of the binding of these pathogens in relation to the sialic acid ligand, particularly the specific linkage to the underlying sugar chain, which determines the preference of the virus for avian versus human hosts (739) (740) (741) (742) (743) (744) (745) (746) (747) (748) (74…”
BackgroundImai, M., Watanabe, T., Hatta, M., Das, S. C., Ozawa, M., Shinya, K., Zhong, G., Hanson, A., Katsura, H., Watanabe, S., et al. (2012) · Nature · doi:10.1038/nature10831 · Cited by 1,523
Antibody Recognition of a Highly Conserved Influenza Virus Epitope
Ekiert, D. C., Bhabha, G., Elsliger, M.-A., Friesen, R. H. E., Jongeneelen, M., Throsby, M., Goudsmit, J., & Wilson, I. A. (2009) · Science · doi:10.1126/science.1171491 · Cited by 1,326
Self-citationUpdate on Avian Influenza A (H5N1) Virus Infection in Humans
(2008) · New England Journal of Medicine · doi:10.1056/nejmra0707279 · Cited by 860
Role of receptor binding specificity in influenza A virus transmission and pathogenesis
de Graaf, M., & Fouchier, R. A. M. (2014) · The EMBO Journal · doi:10.1002/embj.201387442 · Cited by 435
Metadata
- Authors
- Stevens, J., Blixt, O., Tumpey, T. M., Taubenberger, J. K., Paulson, J. C., & Wilson, I. A.
- Venue
- Science
- Published
- 2006-04-21
- Volume
- 312
- Issue
- 5772
- Pages
- 404-410
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026391844
- Cited by
- 938
- References
- 44
- FWCI
- 54.89
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus. https://app.cochat.ai/papers/10.1126/science.1124513
- The paper
- Stevens, J., Blixt, O., Tumpey, T. M., Taubenberger, J. K., Paulson, J. C., & Wilson, I. A. (2006). Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus. Science. https://doi.org/10.1126/science.1124513
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
