The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Functional Conversion Between A-Type and Delayed Rectifier K + Channels by Membrane Lipids
Abstract
Voltage-gated potassium (Kv) channels control action potential repolarization, interspike membrane potential, and action potential frequency in excitable cells. It is thought that the combinatorial association between distinct α and β subunits determines whether Kv channels function as non-inactivating delayed rectifiers or as rapidly inactivating A-type channels. We show that membrane lipids can convert A-type channels into delayed rectifiers and vice versa. Phosphoinositides remove N-type inactivation from A-type channels by immobilizing the inactivation domains. Conversely, arachidonic acid and its amide anandamide endow delayed rectifiers with rapid voltage-dependent inactivation. The bidirectional control of Kv channel gating by lipids may provide a mechanism for the dynamic regulation of electrical signaling in the nervous system.
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Cites
Membrane Phospholipid Control of Nucleotide Sensitivity of K ATP Channels
Shyng, S.-L., & Nichols, C. G. (1998) · Science · doi:10.1126/science.282.5391.1138 · Cited by 559
Lien, C., Martina, M., Schultz, J. H., Ehmke, H., & Jonas, P. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013066 · Cited by 124
Self-citation
Cited by
PIP 2 Is a Necessary Cofactor for Ion Channel Function: How and Why?
Suh, B.-C., & Hille, B. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125859 · Cited by 646
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
Agarwal, N., Pacher, P., Tegeder, I., Amaya, F., Constantin, C. E., Brenner, G. J., Rubino, T., Michalski, C. W., Marsicano, G., Monory, K., et al. (2007) · Nature Neuroscience · doi:10.1038/nn1916 · Cited by 571
Phosphoinositides regulate ion channels
Hille, B., Dickson, E. J., Kruse, M., Vivas, O., & Suh, B.-C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.010 · Cited by 312
Xia, F., Xie, L., Mihic, A., Gao, X., Chen, Y., Gaisano, H. Y., & Tsushima, R. G. (2008) · Endocrinology · doi:10.1210/en.2008-0161 · Cited by 132
Amendola, J., Woodhouse, A., Martin-Eauclaire, M.-F., & Goaillard, J.-M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5297-11.2012 · Cited by 99
Metadata
- Authors
- Oliver, D., Lien, C.-C., Soom, M., Baukrowitz, T., Jonas, P., & Fakler, B.
- Venue
- Science
- Published
- 2004-04-09
- Volume
- 304
- Issue
- 5668
- Pages
- 265-270
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2100784365
- Cited by
- 317
- References
- 2
- FWCI
- 11.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Oliver, D., Lien, C.-C., Soom, M., Baukrowitz, T., Jonas, P., & Fakler, B. (2004). Functional Conversion Between A-Type and Delayed Rectifier K + Channels by Membrane Lipids. Science. https://doi.org/10.1126/science.1094113
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