The DOI matches its Crossref record.
HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
Abstract
Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.
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Citations
Cited by
MHC class I molecules and kirs in human history, health and survival
Parham, P. (2005) · Nature Reviews Immunology · doi:10.1038/nri1570 · Cited by 1,203
Hiby, S. E., Walker, J. J., O'Shaughnessy, K. M., Redman, C. W. G., Carrington, M., Trowsdale, J., & Moffett, A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041214 · Cited by 1,121
Self-citationRedefining Chronic Viral Infection
Virgin, H. W., Wherry, E. J., & Ahmed, R. (2009) · Cell · doi:10.1016/j.cell.2009.06.036 · Cited by 1,031
Liver: An organ with predominant innate immunity
Gao, B., Jeong, W.-I., & Tian, Z. (2008) · Hepatology · doi:10.1002/hep.22034 · Cited by 952
Radaeva, S., Sun, R., Jaruga, B., Nguyen, V. T., Tian, Z., & Gao, B. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.055 · Cited by 610
Metadata
- Authors
- Khakoo, S. I., Thio, C. L., Martin, M. P., Brooks, C. R., Gao, X., Astemborski, J., Cheng, J., Goedert, J. J., Vlahov, D., Hilgartner, M., Cox, S., Little, A.-M., Alexander, G. J., Cramp, M. E., O'Brien, S. J., Rosenberg, W. M. C., Thomas, D. L., & Carrington, M.
- Venue
- Science
- Published
- 2004-08-06
- Volume
- 305
- Issue
- 5685
- Pages
- 872-874
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2107749930
- Cited by
- 1,179
- References
- 0
- FWCI
- 21.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Khakoo, S. I., Thio, C. L., Martin, M. P., Brooks, C. R., Gao, X., Astemborski, J., Cheng, J., Goedert, J. J., Vlahov, D., Hilgartner, M., Cox, S., Little, A.-M., Alexander, G. J., Cramp, M. E., O'Brien, S. J., Rosenberg, W. M. C., Thomas, D. L., & Carrington, M. (2004). HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection. Science. https://doi.org/10.1126/science.1097670
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
