The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success
Open accessAbstract
Preeclampsia is a serious complication of pregnancy in which the fetus receives an inadequate supply of blood due to failure of trophoblast invasion. There is evidence that the condition has an immunological basis. The only known polymorphic histocompatibility antigens on the fetal trophoblast are HLA-C molecules. We tested the idea that recognition of these molecules by killer immunoglobulin receptors (KIRs) on maternal decidual NK cells is a key factor in the development of preeclampsia. Striking differences were observed when these polymorphic ligand: receptor pairs were considered in combination. Mothers lacking most or all activating KIR (AA genotype) when the fetus possessed HLA-C belonging to the HLA-C2 group were at a greatly increased risk of preeclampsia. This was true even if the mother herself also had HLA-C2, indicating that neither nonself nor missing-self discrimination was operative. Thus, this interaction between maternal KIR and trophoblast appears not to have an immune function, but instead plays a physiological role related to placental development. Different human populations have a reciprocal relationship between AA frequency and HLA-C2 frequency, suggesting selection against this combination. In light of our findings, reproductive success may have been a factor in the evolution and maintenance of human HLA-C and KIR polymorphisms.
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Cites
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Self-citationNatural killer cells and pregnancy
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Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
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Self-citationHLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection
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Self-citationKIR: Diverse, Rapidly Evolving Receptors of Innate and Adaptive Immunity
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Human Decidual Natural Killer Cells Are a Unique NK Cell Subset with Immunomodulatory Potential
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Self-citationPaternal and Maternal Components of the Predisposition to Preeclampsia
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Cited by
Latest Advances in Understanding Preeclampsia
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Self-citationSingle-cell reconstruction of the early maternal–fetal interface in humans
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Self-citationRana (2019) · doi:10.1161/circresaha.118.313276 · Cited by 2,095
MHC class I molecules and kirs in human history, health and survival
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Immunology of placentation in eutherian mammals
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Metadata
- Authors
- Hiby, S. E., Walker, J. J., O'Shaughnessy, K. M., Redman, C. W. G., Carrington, M., Trowsdale, J., & Moffett, A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2004-10-11
- Volume
- 200
- Issue
- 8
- Pages
- 957-965
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2163751839
- Cited by
- 1,121
- References
- 52
- FWCI
- 19.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Hiby, S. E., Walker, J. J., O'Shaughnessy, K. M., Redman, C. W. G., Carrington, M., Trowsdale, J., & Moffett, A. (2004). Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20041214
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