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Dissection of the Mammalian Midbody Proteome Reveals Conserved Cytokinesis Mechanisms
Open accessAbstract
Cytokinesis is the essential process that partitions cellular contents into daughter cells. To identify and characterize cytokinesis proteins rapidly, we used a functional proteomic and comparative genomic strategy. Midbodies were isolated from mammalian cells, proteins were identified by multidimensional protein identification technology (MudPIT), and protein function was assessed in Caenorhabditis elegans . Of 172 homologs disrupted by RNA interference, 58% displayed defects in cleavage furrow formation or completion, or germline cytokinesis. Functional dissection of the midbody demonstrated the importance of lipid rafts and vesicle trafficking pathways in cytokinesis, and the utilization of common membrane cytoskeletal components in diverse morphogenetic events in the cleavage furrow, the germline, and neurons.
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Citations
Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Cited by
Dynamin, a membrane-remodelling GTPase
Ferguson, S. M., & De Camilli, P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3266 · Cited by 992
Parallels Between Cytokinesis and Retroviral Budding: A Role for the ESCRT Machinery
Carlton, J. G., & Martin-Serrano, J. (2007) · Science · doi:10.1126/science.1143422 · Cited by 764
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis
Morita, E., Sandrin, V., Chung, H., Morham, S. G., Gygi, S. P., Rodesch, C. K., & Sundquist, W. I. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601850 · Cited by 724
The Molecular Requirements for Cytokinesis
Glotzer, M. (2005) · Science · doi:10.1126/science.1096896 · Cited by 708
Animal Cytokinesis: From Parts List to Mechanisms
Eggert, U. S., Mitchison, T. J., & Field, C. M. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133425 · Cited by 441
Metadata
- Authors
- Skop, A. R., Liu, H., Yates, J., Meyer, B. J., & Heald, R.
- Venue
- Science
- Published
- 2004-07-02
- Volume
- 305
- Issue
- 5680
- Pages
- 61-66
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2080386975
- Cited by
- 516
- References
- 1
- FWCI
- 12.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Skop, A. R., Liu, H., Yates, J., Meyer, B. J., & Heald, R. (2004). Dissection of the Mammalian Midbody Proteome Reveals Conserved Cytokinesis Mechanisms. Science. https://doi.org/10.1126/science.1097931
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