The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Hedgehog Response Network: Sensors, Switches, and Routers
Abstract
The Hedgehog (Hh) signaling pathway is intimately linked to cell growth and differentiation, with normal roles in embryonic pattern formation and adult tissue homeostasis and pathological roles in tumor initiation and growth. Recent advances in our understanding of Hh response have resulted from the identification of new pathway components and new mechanisms of action for old pathway components. The most striking new finding is that signal transmission from membrane to cytoplasm proceeds through recruitment, by the seven-transmembrane protein Smoothened, of an atypical kinesin, which routes pathway activation by interaction with other components of a complex that includes the latent zinc finger transcription factor, Ci.
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Cites
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Patched acts catalytically to suppress the activity of Smoothened
Taipale, J., Cooper, M. K., Maiti, T., & Beachy, P. A. (2002) · Nature · doi:10.1038/nature00989 · Cited by 794
Self-citationShaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
Jia, J., Amanai, K., Wang, G., Tang, J., Wang, B., & Jiang, J. (2002) · Nature · doi:10.1038/nature733 · Cited by 288
Similarities between the Hedgehog and Wnt signaling pathways
Kalderon, D. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02388-7 · Cited by 141
Cited by
Hedgehog: functions and mechanisms
Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217
Tissue repair and stem cell renewal in carcinogenesis
Beachy, P. A., Karhadkar, S. S., & Berman, D. M. (2004) · Nature · doi:10.1038/nature03100 · Cited by 1,208
Self-citationThe casein kinase 1 family: participation in multiple cellular processes in eukaryotes
Knippschild, U., Gocht, A., Wolff, S., Huber, N., Löhler, J., & Stöter, M. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2004.12.011 · Cited by 601
Liu, A., Wang, B., & Niswander, L. A. (2005) · Development · doi:10.1242/dev.01894 · Cited by 494
Svärd, J., Henricson, K. H., Persson-Lek, M., Rozell, B., Lauth, M., Bergström, Å., Ericson, J., Toftgård, R., & Teglund, S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.12.013 · Cited by 468
Metadata
- Authors
- Lum, L., & Beachy, P. A.
- Venue
- Science
- Published
- 2004-06-18
- Volume
- 304
- Issue
- 5678
- Pages
- 1755-1759
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997889647
- Cited by
- 838
- References
- 4
- FWCI
- 23.73
- Type
- journal article
- Language
- en
- Open access
- closed
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