Similarities between the Hedgehog and Wnt signaling pathways

Kalderon, Daniel

doi:10.1016/s0962-8924(02)02388-7

Cited by 141Wnt/β-catenin signaling in development and cancerHedgehog Signaling Pathway StudiesHippo pathway signaling and YAP/TAZ

The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.

Similarities between the Hedgehog and Wnt signaling pathways

Kalderon, Daniel·2002·Trends in Cell Biology

DOI 10.1016/s0962-8924(02)02388-7

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Abstract

Hedgehog and Wnt proteins are signaling molecules that direct many aspects of metazoan development through signal transduction pathways that are just beginning to be understood. Recently, the common use of glycogen synthase kinase 3 and casein kinase 1 has been added to a growing list of straightforward similarities between Hedgehog and Wnt signaling pathways. These kinases silence both pathways by labeling a key transcription factor (Cubitus interruptus) or co-activator (beta-catenin) for proteolysis, and it is possible that reversal of these phosphorylation events is, in each case, central to pathway activation. This review compares the two pathways to explore whether our more extensive knowledge of Wnt pathways can be of predictive value for investigating Hedgehog signaling.

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There is much cross-talk between the Hedgehog/Smoothened pathway and the Wnt pathway through GSK-3β and casein kinase I.
“there is much cross-talk with the Wnt pathway through GSK-3β and casein kinase I (115–118)”
From Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation (2011) · cites this paper as [118]

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Authors: Kalderon, D.
Affiliations: Columbia University (US)
Corresponding author: Kalderon, Daniel
ORCID: Kalderon, Daniel
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2002-11
Volume: 12
Issue: 11
Pages: 523-531
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/s0962-8924(02)02388-7
OpenAlex: W2038585541
Cited by: 141
References: 74
Citations by year: 2026: 3 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 7 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 4
FWCI: 1.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords: Hedgehog signaling, Wnt signaling, glycogen synthase kinase-3, casein kinase 1, Cubitus interruptus, β-catenin, protein phosphorylation, proteolysis, transcriptional coactivator, signal transduction, developmental signaling
MeSH terms: Animals, Cytoskeletal Proteins, Drosophila, Proto-Oncogene Proteins, Signal Transduction, Trans-Activators, Drosophila Proteins, Zebrafish Proteins, Wnt Proteins, beta Catenin, Hedgehog Proteins

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