The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic
Open accessAbstract
Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor subtype–selective ligands allowing the separation of EPO's bioactivities at the cellular level and in animals. Carbamylated EPO (CEPO) or certain EPO mutants did not bind to the classical EPO receptor (EPOR) and did not show any hematopoietic activity in human cell signaling assays or upon chronic dosing in different animal species. Nevertheless, CEPO and various nonhematopoietic mutants were cytoprotective in vitro and conferred neuroprotection against stroke, spinal cord compression, diabetic neuropathy, and experimental autoimmune encephalomyelitis at a potency and efficacy comparable to EPO.
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Cites
Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury
Brines, M. L., Ghezzi, P., Keenan, S., Agnello, D., de Lanerolle, N. C., Cerami, C., Itri, L. M., & Cerami, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.19.10526 · Cited by 1,402
Self-citationErythropoietin Therapy for Acute Stroke Is Both Safe and Beneficial
Ehrenreich, H., Hasselblatt, M., Dembowski, C., Cepek, L., Lewczuk, P., Stiefel, M., Rustenbeck, H.-H., Breiter, N., Jacob, S., Knerlich, F., et al. (2002) · Molecular Medicine · doi:10.1007/bf03402029 · Cited by 1,028
Self-citationErythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
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Self-citationIn vivo evidence that erythropoietin protects neurons from ischemic damage
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Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo
Erbayraktar, S., Grasso, G., Sfacteria, A., Xie, Q.-W., Coleman, T., Kreilgaard, M., Torup, L., Sager, T., Erbayraktar, Z., Gokmen, N., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1031753100 · Cited by 436
Self-citationMasuda, S., Nagao, M., Takahata, K., Konishi, Y., Gallyas, F., Tabira, T., & Sasaki, R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82112-3 · Cited by 421
Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans
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Erythropoietin both protects from and reverses experimental diabetic neuropathy
Bianchi, R., Buyukakilli, B., Brines, M., Savino, C., Cavaletti, G., Oggioni, N., Lauria, G., Borgna, M., Lombardi, R., Cimen, B., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307823100 · Cited by 248
Self-citation
Cited by
Cerebral preconditioning and ischaemic tolerance
Gidday, J. M. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1927 · Cited by 751
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Emerging biological roles for erythropoietin in the nervous system
Brines, M., & Cerami, A. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1687 · Cited by 523
Self-citationThe non‐haematopoietic biological effects of erythropoietin
Arcasoy, M. O. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07014.x · Cited by 347
Neurovascular signalling defects in neurodegeneration
Zacchigna, S., Lambrechts, D., & Carmeliet, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2336 · Cited by 345
Metadata
- Authors
- Leist, M., Ghezzi, P., Grasso, G., Bianchi, R., Villa, P., Fratelli, M., Savino, C., Bianchi, M., Nielsen, J., Gerwien, J., Kallunki, P., Larsen, A. K., Helboe, L., Christensen, S., Pedersen, L. O., Nielsen, M., Torup, L., Sager, T., Sfacteria, A., Erbayraktar, S., Erbayraktar, Z., Gokmen, N., Yilmaz, O., Cerami-Hand, C., Xie, Q.-W., Coleman, T., Cerami, A., & Brines, M.
- Venue
- Science
- Published
- 2004-07-09
- Volume
- 305
- Issue
- 5681
- Pages
- 239-242
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2109723592
- Cited by
- 803
- References
- 18
- FWCI
- 35.29
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic. https://app.cochat.ai/papers/10.1126/science.1098313
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- Leist, M., Ghezzi, P., Grasso, G., Bianchi, R., Villa, P., Fratelli, M., Savino, C., Bianchi, M., Nielsen, J., Gerwien, J., Kallunki, P., Larsen, A. K., Helboe, L., Christensen, S., Pedersen, L. O., Nielsen, M., Torup, L., Sager, T., Sfacteria, A., . . . Brines, M. (2004). Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic. Science. https://doi.org/10.1126/science.1098313
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
