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Intercontinental Spread of Pyrimethamine-Resistant Malaria
Abstract
Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally arrived in Africa from southeast Asia. The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis.
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Cited by
Artemisinin Resistance in Plasmodium falciparum Malaria
Dondorp, A. M., Nosten, F., Yi, P., Das, D., Phyo, A. P., Tarning, J., Lwin, K. M., Ariey, F., Hanpithakpong, W., Lee, S. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808859 · Cited by 3,424
Self-citationA molecular marker of artemisinin-resistant Plasmodium falciparum malaria
Ariey, F., Witkowski, B., Amaratunga, C., Beghain, J., Langlois, A.-C., Khim, N., Kim, S., Duru, V., Bouchier, C., Ma, L., et al. (2014) · Nature · doi:10.1038/nature12876 · Cited by 2,090
Global Transport Networks and Infectious Disease Spread
Tatem, A. J., Rogers, D. J., & Hay, S. I. (2006) · Advances in Parasitology · doi:10.1016/s0065-308x(05)62009-x · Cited by 630
Mechanisms of Resistance of Malaria Parasites to Antifolates
Gregson, A., & Plowe, C. V. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.1.4 · Cited by 499
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
Miotto, O., Almagro-Garcia, J., Manske, M., MacInnis, B., Campino, S., Rockett, K. A., Amaratunga, C., Lim, P., Suon, S., Sreng, S., et al. (2013) · Nature Genetics · doi:10.1038/ng.2624 · Cited by 462
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Metadata
- Authors
- Roper, C., Pearce, R., Nair, S., Sharp, B., Nosten, F., & Anderson, T.
- Venue
- Science
- Published
- 2004-08-20
- Volume
- 305
- Issue
- 5687
- Pages
- 1124-1124
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984669077
- Cited by
- 510
- References
- 0
- FWCI
- 22.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Roper, C., Pearce, R., Nair, S., Sharp, B., Nosten, F., & Anderson, T. (2004). Intercontinental Spread of Pyrimethamine-Resistant Malaria. Science. https://doi.org/10.1126/science.1098876
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
