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Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils
Abstract
Eosinophils are often dominant inflammatory cells present in the lungs of asthma patients. Nonetheless, the role of these leukocytes remains poorly understood. We have created a transgenic line of mice (PHIL) that are specifically devoid of eosinophils, but otherwise have a full complement of hematopoietically derived cells. Allergen challenge of PHIL mice demonstrated that eosinophils were required for pulmonary mucus accumulation and the airway hyperresponsiveness associated with asthma. The development of an eosinophil-less mouse now permits an unambiguous assessment of a number of human diseases that have been linked to this granulocyte, including allergic diseases, parasite infections, and tumorigenesis.
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Cited by
Rothenberg, M. E., & Hogan, S. P. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090720 · Cited by 1,356
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
Gudbjartsson, D. F., Bjornsdottir, U. S., Halapi, E., Helgadottir, A., Sulem, P., Jonsdottir, G. M., Thorleifsson, G., Helgadottir, H., Steinthorsdottir, V., Stefansson, H., et al. (2009) · Nature Genetics · doi:10.1038/ng.323 · Cited by 677
The developmental origins of adult disease
Gluckman, P. D., Hanson, M. A., & Pinal, C. (2005) · Maternal & Child Nutrition · doi:10.1111/j.1740-8709.2005.00020.x · Cited by 473
The fetal, neonatal, and infant environments-the long-term consequences for disease risk
Gluckman, P. D., Cutfield, W., Hofman, P., & Hanson, M. A. (2005) · Early Human Development · doi:10.1016/j.earlhumdev.2004.10.003 · Cited by 326
T-helper cell type-2 regulation in allergic disease
Georas, S. N., Guo, J., De Fanis, U., & Casolaro, V. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00006005 · Cited by 181
Metadata
- Authors
- Lee, J. J., Dimina, D., Macias, M. P., Ochkur, S. I., McGarry, M. P., O'Neill, K. R., Protheroe, C., Pero, R., Nguyen, T., Cormier, S. A., Lenkiewicz, E., Colbert, D., Rinaldi, L., Ackerman, S. J., Irvin, C. G., & Lee, N. A.
- Venue
- Science
- Published
- 2004-09-17
- Volume
- 305
- Issue
- 5691
- Pages
- 1773-1776
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2140942460
- Cited by
- 711
- References
- 0
- FWCI
- 30.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, J. J., Dimina, D., Macias, M. P., Ochkur, S. I., McGarry, M. P., O'Neill, K. R., Protheroe, C., Pero, R., Nguyen, T., Cormier, S. A., Lenkiewicz, E., Colbert, D., Rinaldi, L., Ackerman, S. J., Irvin, C. G., & Lee, N. A. (2004). Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils. Science. https://doi.org/10.1126/science.1099472
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
