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The Genomic Sequence of the Accidental Pathogen Legionella pneumophila
Abstract
We present the genomic sequence of Legionella pneumophila , the bacterial agent of Legionnaires' disease, a potentially fatal pneumonia acquired from aerosolized contaminated fresh water. The genome includes a 45âkilobase pair element that can exist in chromosomal and episomal forms, selective expansions of important gene families, genes for unexpected metabolic pathways, and previously unknown candidate virulence determinants. We highlight the genes that may account for Legionella 's ability to survive in protozoa, mammalian macrophages, and inhospitable environmental niches and that may define new therapeutic targets.
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Cited by
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Molecular Pathogenesis of Infections Caused by Legionella pneumophila
Newton, H. J., Ang, D. K. Y., van Driel, I. R., & Hartland, E. L. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00052-09 · Cited by 494
Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors
Pan, X., Lührmann, A., Satoh, A., Laskowski-Arce, M. A., & Roy, C. R. (2008) · Science · doi:10.1126/science.1158160 · Cited by 388
Weber, S. S., Ragaz, C., Reus, K., Nyfeler, Y., & Hilbi, H. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020046 · Cited by 292
Bruggemann, H., Hagman, A., Jules, M., Sismeiro, O., Dillies, M.-A., Gouyette, C., Kunst, F., Steinert, M., Heuner, K., Coppee, J.-Y., et al. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00703.x · Cited by 273
Metadata
- Authors
- Chien, M., Morozova, I., Shi, S., Sheng, H., Chen, J., Gomez, S. M., Asamani, G., Hill, K., Nuara, J., Feder, M., Rineer, J., Greenberg, J. J., Steshenko, V., Park, S. H., Zhao, B., Teplitskaya, E., Edwards, J. R., Pampou, S., Georghiou, A., Chou, I.-C., Iannuccilli, W., Ulz, M. E., Kim, D. H., Geringer-Sameth, A., Goldsberry, C., Morozov, P., Fischer, S. G., Segal, G., Qu, X., Rzhetsky, A., Zhang, P., Cayanis, E., De Jong, P. J., Ju, J., Kalachikov, S., Shuman, H. A., & Russo, J. J.
- Venue
- Science
- Published
- 2004-09-24
- Volume
- 305
- Issue
- 5692
- Pages
- 1966-1968
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2136246773
- Cited by
- 461
- References
- 0
- FWCI
- 17.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Genomic Sequence of the Accidental Pathogen Legionella pneumophila. https://app.cochat.ai/papers/10.1126/science.1099776
- The paper
- Chien, M., Morozova, I., Shi, S., Sheng, H., Chen, J., Gomez, S. M., Asamani, G., Hill, K., Nuara, J., Feder, M., Rineer, J., Greenberg, J. J., Steshenko, V., Park, S. H., Zhao, B., Teplitskaya, E., Edwards, J. R., Pampou, S., Georghiou, A., . . . Russo, J. J. (2004). The Genomic Sequence of the Accidental Pathogen Legionella pneumophila. Science. https://doi.org/10.1126/science.1099776
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
