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Spatial Coordination of Cytokinetic Events by Compartmentalization of the Cell Cortex
Abstract
During cytokinesis, furrow ingression and plasma membrane fission irreversibly separate daughter cells. How actomyosin ring assembly and contraction, vesicle fusion, and abscission are spatially coordinated was unknown. We found that during cytokinesis septin rings, located on both sides of the actomyosin ring, acted as barriers to compartmentalize the cortex around the cleavage site. Compartmentalization maintained diffusible cortical factors, such as the exocyst and the polarizome, to the site of cleavage. In turn, such factors were required for actomyosin ring function and membrane abscission. Thus, a specialized cortical compartment ensures the spatial coordination of cytokinetic events.
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Citations
Cited by
Cell Wall Assembly in Saccharomyces cerevisiae
Lesage, G., & Bussey, H. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00038-05 · Cited by 849
Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission
Estey, M. P., Di Ciano-Oliveira, C., Froese, C. D., Bejide, M. T., & Trimble, W. S. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006031 · Cited by 231
Septin filaments exhibit a dynamic, paired organization that is conserved from yeast to mammals
DeMay, B. S., Bai, X., Howard, L., Occhipinti, P., Meseroll, R. A., Spiliotis, E. T., Oldenbourg, R., & Gladfelter, A. S. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201012143 · Cited by 122
Three-dimensional ultrastructure of the septin filament network in Saccharomyces cerevisiae
Bertin, A., McMurray, M. A., Pierson, J., Thai, L., McDonald, K. L., Zehr, E. A., García, G., Peters, P., Thorner, J., & Nogales, E. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0850 · Cited by 106
DeMay, B. S., Noda, N., Gladfelter, A. S., & Oldenbourg, R. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.07.008 · Cited by 74
Metadata
- Authors
- Dobbelaere, J., & Barral, Y.
- Venue
- Science
- Published
- 2004-07-16
- Volume
- 305
- Issue
- 5682
- Pages
- 393-396
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2048400182
- Cited by
- 291
- References
- 0
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
