The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Activation of Endogenous Cdc42 Visualized in Living Cells
Abstract
Signaling proteins are tightly regulated spatially and temporally to perform multiple functions. For Cdc42 and other guanosine triphosphatases, the subcellular location of activation is a critical determinant of cell behavior. However, current approaches are limited in their ability to examine the dynamics of Cdc42 activity in living cells. We report the development of a biosensor capable of visualizing the changing activation of endogenous, unlabeled Cdc42 in living cells. With the use of a dye that reports protein interactions, the biosensor revealed localized activation in the trans-Golgi apparatus, microtubule-dependent Cdc42 activation at the cell periphery, and activation kinetics precisely coordinated with cell extension and retraction.
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Cites
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Cited by
Actin and Actin-Binding Proteins
Pollard, T. D. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018226 · Cited by 912
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Self-citationMitochondrial Cristae: Where Beauty Meets Functionality
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Directed cell invasion and migration during metastasis
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Metadata
- Authors
- Nalbant, P., Hodgson, L., Kraynov, V., Toutchkine, A., & Hahn, K. M.
- Venue
- Science
- Published
- 2004-09-10
- Volume
- 305
- Issue
- 5690
- Pages
- 1615-1619
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2123555845
- Cited by
- 391
- References
- 31
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nalbant, P., Hodgson, L., Kraynov, V., Toutchkine, A., & Hahn, K. M. (2004). Activation of Endogenous Cdc42 Visualized in Living Cells. Science. https://doi.org/10.1126/science.1100367
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
