The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cdc42 - the centre of polarity
Abstract
All cell types polarize, at least transiently, during division or to generate specialized shapes and functions. This capacity extends from yeast to mammals, and it is now clear that many features of the molecular mechanisms controlling polarization are conserved in all eukaryotic cells. At the centre of the action is Cdc42, a small GTPase of the Rho family. Its activity is precisely controlled both temporally and spatially, and this can be achieved by a wide variety of extracellular cues in multicellular organisms. Moreover, although the functional characteristics of cell polarity are extremely variable (depending on the cell type and the biological context), Cdc42 has an amazing capacity to co-ordinate the control of multiple signal transduction pathways.
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Citations
Cites
Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity
Etienne-Manneville, S., & Hall, A. (2003) · Nature · doi:10.1038/nature01423 · Cited by 835
Self-citationAdaptation of core mechanisms to generate cell polarity
Nelson, W. J. (2003) · Nature · doi:10.1038/nature01602 · Cited by 716
Integrated activity of PDZ protein complexes regulates epithelial polarity
Bilder, D., Schober, M., & Perrimon, N. (2003) · Nature Cell Biology · doi:10.1038/ncb897 · Cited by 435
Yamanaka, T., Horikoshi, Y., Suzuki, A., Sugiyama, Y., Kitamura, K., Maniwa, R., Nagai, Y., Yamashita, A., Hirose, T., Ishikawa, H., et al. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00453.x · Cited by 306
Suzuki, A., Ishiyama, C., Hashiba, K., Shimizu, M., Ebnet, K., & Ohno, S. (2002) · Journal of Cell Science · doi:10.1242/jcs.00032 · Cited by 251
Cited by
Mammalian Rho GTPases: new insights into their functions from in vivo studies
Heasman, S. J., & Ridley, A. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2476 · Cited by 1,871
Microtubule assembly, organization and dynamics in axons and dendrites
Conde, C., & Cáceres, A. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2631 · Cited by 1,086
The ageing haematopoietic stem cell compartment
Geiger, H., de Haan, G., & Florian, M. C. (2013) · Nature Reviews Immunology · doi:10.1038/nri3433 · Cited by 604
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation
Florian, M. C., Dörr, K., Niebel, A., Daria, D., Schrezenmeier, H., Rojewski, M., Filippi, M.-D., Hasenberg, A., Gunzer, M., Scharffetter-Kochanek, K., et al. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.04.007 · Cited by 564
“To test this we initially determined the localization of Cdc42, which in itself is a cell polarity marker (Etienne-Manneville, 2004), and tubulin in LT-HSCs in single-cell immunofluorescence (IF) analyses performed on LT-HSCs.”
Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation
Bedzhov, I., & Zernicka-Goetz, M. (2014) · Cell · doi:10.1016/j.cell.2014.01.023 · Cited by 448
Metadata
- Authors
- Etienne-Manneville, S.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2004-03-15
- Volume
- 117
- Issue
- 8
- Pages
- 1291-1300
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2020410964
- Cited by
- 749
- References
- 5
- FWCI
- 11.81
- Type
- journal article
- Language
- en
- Open access
- closed
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