The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Mathematical Modeling of Planar Cell Polarity to Understand Domineering Nonautonomy
Abstract
Planar cell polarity (PCP) signaling generates subcellular asymmetry along an axis orthogonal to the epithelial apical-basal axis. Through a poorly understood mechanism, cell clones that have mutations in some PCP signaling components, including some, but not all, alleles of the receptor frizzled , cause polarity disruptions of neighboring wild-type cells, a phenomenon referred to as domineering nonautonomy. Here, a contact-dependent signaling hypothesis, derived from experimental results, is shown by reaction-diffusion, partial differential equation modeling and simulation to fully reproduce PCP phenotypes, including domineering nonautonomy, in the Drosophila wing. The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy.
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Sick, S., Reinker, S., Timmer, J., & Schlake, T. (2006) · Science · doi:10.1126/science.1130088 · Cited by 612
Principles of planar polarity in animal development
Goodrich, L. V., & Strutt, D. (2011) · Development · doi:10.1242/dev.054080 · Cited by 579
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility
Seifert, J. R. K., & Mlodzik, M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2042 · Cited by 513
Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell cycle exit
Matei, V., Pauley, S., Kaing, S., Rowitch, D., Beisel, K. W., Morris, K., Feng, F., Jones, K., Lee, J., & Fritzsch, B. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20551 · Cited by 435
Biological Physics of the Developing Embryo
Forgacs, G., & Newman, S. A. (2005) · doi:10.1017/cbo9780511755576 · Cited by 339
Metadata
- Authors
- Amonlirdviman, K., Khare, N. A., Tree, D. R. P., Chen, W.-S., Axelrod, J. D., & Tomlin, C. J.
- Venue
- Science
- Published
- 2005-01-21
- Volume
- 307
- Issue
- 5708
- Pages
- 423-426
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070050569
- Cited by
- 317
- References
- 28
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Amonlirdviman, K., Khare, N. A., Tree, D. R. P., Chen, W.-S., Axelrod, J. D., & Tomlin, C. J. (2005). Mathematical Modeling of Planar Cell Polarity to Understand Domineering Nonautonomy. Science. https://doi.org/10.1126/science.1105471
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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